METHODS AND COMPOSITIONS FOR THE TREATMENT OF NEUROPSYCHIATRIC AND ADDICTIVE DISORDERS
First Claim
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1. A method for treating a disorder in a mammalian subject, comprising administering an effective amount of a composition comprising a Na+K+2Cl co-transporter antagonist to the subject, wherein the disorder is selected from the group consisting of:
- addictive disorders, and neuropsychiatric disorders.
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Abstract
The present invention relates to methods and compositions for treating neuropathic pain and neuropsychiatric disorders by administering agents that are effective in reducing the effective amount, inactivating, and/or inhibiting the activity of a Na+—K+-2Cl− (NKCC) cotransporter. In certain embodiments, the Na+—K+-2Cl− co-transporter is NKCC1.
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Citations
29 Claims
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1. A method for treating a disorder in a mammalian subject, comprising administering an effective amount of a composition comprising a Na+K+2Cl co-transporter antagonist to the subject, wherein the disorder is selected from the group consisting of:
- addictive disorders, and neuropsychiatric disorders.
- View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29)
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