Device, System and Method for In Vivo Magnetic Immunoassay Analysis

• US 20090216082A1
• Filed: 04/02/2006
• Published: 08/27/2009
• Est. Priority Date: 04/01/2005
• Status: Abandoned Application

• Current Assignee: Given Imaging Limited (Medtronic Plc)
• Original Assignee: Given Imaging Limited (Medtronic Plc)
• Inventors: Rabinovitz, Elisha
• Application Number:
  US11/887,640
• Publication Number:
  US 20090216082A1
• Time in Patent Office: Days
• US Class Current: 600/118
• CPC Class Codes: A61B 10/0045 Devices for taking samples of body liquids devices for taking blood samples A61B5/15
• CPC Class Codes: A61B 2010/0061 Alimentary tract secretions, e.g. biliary, gastric, intestinal, pancreatic secretions
• CPC Class Codes: A61K 49/1818 particles, e.g. uncoated or non-functionalised microparticles or nanoparticles
• CPC Class Codes: B82Y 5/00 Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

Abstract

A device system, and method may provide in-vivo detection of target molecules in an endo-luminal sample, for example for the detection of cancer in the gastrointestinal tract, utilizing for example an in-vivo sensing device. the sensing device may accept samples of fluids from a body lumen and detect the contents of that sample for example by introducing paramagnetic particles to the sample of fluids, immobilizing a target molecule bonded to a paramagnetic particle to a reaction channel, and detecting bonded paramagnetic particles.

Claims

5-1. The in-vivo device of claim 1 comprising a pump, wherein the pump is to pump the in-vivo fluid sample into the reaction channel.

13. A method for in vivo magnetic immunoassay analysis, the method comprising:

collecting a fluid sample in-vivo;

introducing paramagnetic particles to the fluid sample in-vivo, wherein the paramagnetic particles are conjugated with a receptor specific to a target molecule;

applying a magnetic field in-vivo, in the vicinity of the paramagnetic particles; and

detecting in-vivo the paramagnetic particles that bonded to the target molecules.

14. The method of claim 13 comprising immobilizing the paramagnetic particles that bonded to the target molecules.

15. The method of claim 13 wherein the magnetic field is an alternating magnetic field.

16. The method of claim 13 comprising detecting changes in the magnetic field due to the paramagnetic particles bonding to a target molecule.

17. The method of claim 13 comprising flushing excess fluid sample to a waste chamber.

18. The method of claim 13 comprising transmitting by wireless connection, results from the detecting to an external source.

19. The method of claim 13 comprising inserting the in-vivo device into the GI tract.

26. The method of claim 18 comprising displaying the results to a user.

20-25. -25. (canceled)