Transdermal Administration Device and Method of Controlling the Same
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Accused Products
Abstract
To provide a transdermal administration device capable of increasing the speed at which a drug is transferred into a skin and the amount of the drug to be transferred into the skin. A transdermal administration device is constituted by: an electrode supplied with a voltage of a first conductivity type; an electrolyte solution holding portion holding an electrolyte solution energized by the electrode; and a bipolar membrane that is placed on the front surface side of the electrolyte solution holding portion, and is composed of a first ion exchange membrane that selectively passes an ion of the first conductivity type and a second ion exchange membrane that selectively passes an ion of a second conductivity type.
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Citations
32 Claims
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1-12. -12. (canceled)
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13. A transdermal administration device, comprising:
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an electrode operable to receive a voltage of a first charge type; an electrolyte solution holding portion; and a bipolar membrane located on a front surface side of the electrolyte solution holding portion, the bipolar membrane comprising a first ion exchange membrane that selectively passes an ion of the first charge type and a second ion exchange membrane that selectively passes an ion of a second charge type, the first ion exchange membrane having a transport number of about 0.95 or greater for the ions of the first charge type, and the second ion exchange membrane having a transport number of about 0.95 or greater for the ions of the second charge type. - View Dependent Claims (14, 15, 16, 17, 18, 19, 20, 21, 22, 23)
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24. A method for controlling a transdermal administration device, comprising:
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contacting a skin of a living body, that has been treated with a drug solution including a medicinal effective ingredient that dissociates into a drug ion of a second charge type, with a first surface side of a bipolar membrane composed of a first ion exchange membrane that selectively passes an ion of a first charge type and a second ion exchange membrane that selectively passes an ion of the second charge type, the first ion exchange membrane having a transport number of about 0.95 or greater for the ions of the first charge type, and the second ion exchange membrane having a transport number of about 0.95 or greater for the ions of the second charge type; providing an electrode and an electrolyte solution holding portion located on a second surface side opposite to first surface side of the bipolar membrane; sensing a pH of the skin of a living body in contact with the first surface; and intermittently applying a voltage of the first charge type to the electrode based on the sensed pH. - View Dependent Claims (25, 26, 27)
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28. A method of maintaining a pH value of a drug solution at or about a target value, while imparting a sufficient change in pH of skin of a living body contacting a transdermal administration device, during transdermal administration of the drug solution, comprising:
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contacting a skin of a living body with a transdermal administration device comprising a drug solution holding portion and a bipolar membrane composed of a first ion exchange membrane that selectively passes an ion of a first charge type and a second ion exchange membrane that selectively passes an ion of the second charge type, the first ion exchange membrane having a transport number of about 0.95 or greater for the ions of the first charge type, and the second ion exchange membrane having a transport number of about 0.95 or greater for the ions of the second charge type; sensing a pH of the skin of the living body in contact with the transdermal administration device; sensing a pH of the drug solution holding portion; and intermittently applying a voltage of the first charge type or the second charge type based on the sensed pH of drug solution holding portion or the sensed pH of the skin. - View Dependent Claims (29, 30, 31, 32)
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Specification