Medical Device Adapted for Detection of Drug Condition

• US 20090216194A1
• Filed: 09/01/2005
• Published: 08/27/2009
• Est. Priority Date: 09/02/2004
• Status: Abandoned Application

• Current Assignee: Novo Nordisk A/S
• Original Assignee: Novo Nordisk A/S
• Inventors: Elgård Pedersen, Per Erik, Nielsen, John Stern
• Application Number:
  US11/661,868
• Publication Number:
  US 20090216194A1
• Time in Patent Office: Days
• US Class Current: 604/151
• CPC Class Codes: A61M 2005/14252 with needle insertion means
• CPC Class Codes: A61M 2205/3306 Optical measuring means
• CPC Class Codes: A61M 2205/583 by visual feedback
• CPC Class Codes: A61M 2205/587 Lighting arrangements
• CPC Class Codes: A61M 5/14248 of the skin patch type
• CPC Class Codes: A61M 5/145 using pressurised reservoirs, e.g. pressurised by means of pistons
• CPC Class Codes: A61M 5/14566 with a replaceable reservoir for receiving a piston rod of the pump
• CPC Class Codes: A61M 5/322 Retractable needles, i.e. disconnected from and withdrawn into the syringe barrel by the piston devices for protecting guide needles in combination with catheters A61M25/0612
• CPC Class Codes: G01N 21/51 inside a container, e.g. in an ampoule G01N21/53 takes precedence
• CPC Class Codes: G01N 21/532 with measurement of scattering and transmission

Abstract

A drug delivery device is provided, comprising a reservoir adapted to contain a liquid drug, an outlet, and expelling means for, in a situation of use, expelling a drug from the reservoir via the outlet. The device further comprises a light source (575) adapted for directing a beam of light through the drug, and detection means (576, 577) allowing a transmission characteristic of the light beam through the drug to be detected. The detecting means may be either in form of a transparent area allowing a user to inspect a portion of the device through which the light beam is directed, or light detection means used in combination with an electronic controller.

Claims

1. A drug delivery device (650), comprising:

a reservoir (660) adapted to contain a liquid drug,

an expelling assembly (670) for, in a situation of use, expelling a drug from the reservoir,

a light conductor (690) having a light inlet and a light outlet, the light conductor being adapted for conducting light from a point of entrance and into the reservoir (660), and

a transparent area (452) allowing a user to inspect a portion of the reservoir to thereby detect a transmission characteristic of the light through the drug.

2. A device as in claim 1, wherein the light inlet is arranged to receive light generated external to the device.

3. A device as in claim 2, comprising a visible light generating source associated with the light inlet.

4. A device as in any of claim 1, wherein one or more light conductors are arranged to substantially illuminate the interior of the reservoir.

5. A device as in claim 1, wherein the light conductor is adapted to direct a beam of light through the reservoir.

6. A device as in any of claim 1, wherein the reservoir (690) comprises first and second flexible foil members sealed together to form a reservoir having a pouch-like configuration defining a general plane, the reservoir having a rounded edge portion through which the light is directed.

7. A device as in claim 5, wherein the expelling assembly comprises a pump having, in a situation of use, an inlet (580) in fluid communication with the reservoir.

8. A device as in any of claim 1, wherein the reservoir is in the form of a cylindrical member (201) with a piston slidably arranged there within.

9. A device as in claim 8, wherein the expelling assembly comprises a piston actuator, an electronic controller for controlling the piston actuator, and an energy source.

10. A device as in claim 1, wherein the light conductor is adapted to deflect incoming light to thereby direct it to the reservoir.

11. A device as in claim 1, further comprising:

a lower surface (12) adapted for application towards the skin of a subject,

a transcutaneous device adapted to penetrate the skin of the subject, the transcutaneous device being arranged in fluid communication with or being adapted to be arranged in fluid communication with the reservoir.

12. A device as in claim 11, wherein the expelling assembly comprises a dose setting member (171) moveable to a selected set position representing a set dose of drug to be delivered, and a user actuation member (175) allowing the set dose to be expelled.

17. A device as claim 1, wherein:

at least a portion of the transmitted light is detectable by the human eye, and

the detection means comprises a transparent area allowing a user to inspect a portion of the device through which the light beam is directed through the drug.

18. A device as in claim 1, wherein the light generating means (575) is arranged external to a structure in which the drug is enclosed, the structure comprising a transparent portion allowing the light beam to enter the structure.

19. A device as in claim 1, wherein the detection means comprises:

control means (583),

one or more light detection means (575, 576), each light detection means being adapted to detect light from the light generating means (575) and transmit a signal indicative of a characteristic of the detected light to the control means, wherein

the control means is adapted to identify on the basis of the transmitted signal(s) a first and a second condition for a given drug, and to generate a signal when the second condition has been identified.

20. A device as in claim 1, wherein the reservoir is in the form of a flexible reservoir (560) formed from foil material.

21. A device as in claim 20, wherein the expelling assembly comprises a pump having, in a situation of use, an inlet (580) in fluid communication with the reservoir, and being connected to or comprising an outlet (590).

22. A device as in claim 1, wherein the reservoir is in the form of a cylindrical member (201) with a piston slidably arranged there within.

23. A device as in claim 22, wherein the expelling assembly comprises a piston actuator, an electronic controller for controlling the piston actuator, and an energy source.

24. A device as in claim 1, further comprising:

a lower surface (12) adapted for application towards the skin of a subject,

a transcutaneous device adapted to penetrate the skin of the subject, the transcutaneous device comprising an inlet in fluid communication with or being adapted to be arranged in fluid communication with the reservoir.

25. A device as in claim 23, wherein the expelling means comprising a dose setting member (171) moveable to a selected set position representing a set dose of drug to be delivered, and a user actuation member (175) allowing the set dose to be expelled.

13. A drug delivery device (500), comprising:

a reservoir (560) adapted to contain a liquid drug,

an expelling assembly (570) for, in a situation of use, expelling a drug from the reservoir,

a light source (575) adapted for directing a beam of light through the drug, and

detection means (576) allowing a transmission characteristic of the light beam through the drug to be detected.

14. A device as in claim 13, wherein the light is directed through a portion of the reservoir (201).

15. A device as in claim 13, comprising a passageway (572) arranged between the reservoir and an outlet, the beam of light being directed through a portion of the passageway.

16. A device as in claim 15, the passageway comprising a cavity (571), wherein the detection means (576) is associated with the cavity.