METHOD TO DETERMINE THE DEGREE AND STABILITY OF BLOOD GLUCOSE CONTROL IN PATIENTS WITH DIABETES MELLITUS VIA CREATION AND CONTINUOUS UPDATING OF NEW STATISTICAL INDICATORS
First Claim
1. A method for determining a stability of a blood glucose concentration of a patient, the method comprising:
- providing a plurality of blood glucose concentration test results each taken from the patient at a different time over a time period;
approximating a plurality of blood glucose concentration test result values as functions of time from consecutive ones of the plurality of blood glucose concentration test results;
computing a time averaged glucose value as a first indicator by averaging the approximated blood glucose concentration test result values over the time period;
applying a time-based weight to each of the blood glucose concentration test results by multiplying each of the blood glucose concentration test results by a respective coefficient;
computing a weighted average by averaging the time-based weighted blood glucose concentration test results;
computing a simulated measurement of a blood hemoglobin as a second indicator by correlating with a pre-determined formula the weighted average of the time-based weighted blood glucose concentration test results and the blood hemoglobin;
computing a variance of the blood glucose concentration test results;
computing a standard deviation of the variance of the blood glucose concentration test results;
computing a ratio of the standard deviation to the time averaged glucose value to give a third indicator representing variability of blood glucose concentration over the time period; and
providing the first, second, and third indicators.
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Accused Products
Abstract
Systems and methods for determining a stability of a blood glucose concentration of a patient are provided. The system comprises a processor that may be programmed to receive blood glucose concentration test results each taken from the patient at a different time over a time period and to compute a time-averaged glucose parameter indicative of blood glucose concentration control over the time period. In addition, the processor may be programmed to compute a virtual blood hemoglobin parameter through a simulated measurement of a blood hemoglobin, the virtual blood hemoglobin parameter being indicative of blood glucose concentration control over an extended time period encompassing the time period. Further, the processor may be programmed to compute a lability factor parameter indicative of a variability in blood glucose concentration over the time period.
6 Citations
20 Claims
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1. A method for determining a stability of a blood glucose concentration of a patient, the method comprising:
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providing a plurality of blood glucose concentration test results each taken from the patient at a different time over a time period; approximating a plurality of blood glucose concentration test result values as functions of time from consecutive ones of the plurality of blood glucose concentration test results; computing a time averaged glucose value as a first indicator by averaging the approximated blood glucose concentration test result values over the time period; applying a time-based weight to each of the blood glucose concentration test results by multiplying each of the blood glucose concentration test results by a respective coefficient; computing a weighted average by averaging the time-based weighted blood glucose concentration test results; computing a simulated measurement of a blood hemoglobin as a second indicator by correlating with a pre-determined formula the weighted average of the time-based weighted blood glucose concentration test results and the blood hemoglobin; computing a variance of the blood glucose concentration test results; computing a standard deviation of the variance of the blood glucose concentration test results; computing a ratio of the standard deviation to the time averaged glucose value to give a third indicator representing variability of blood glucose concentration over the time period; and providing the first, second, and third indicators. - View Dependent Claims (2, 3, 4, 5, 6, 7)
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8. A system for determining a stability of a blood glucose concentration of a patient, the system comprising:
a processor programmed to; receive a plurality of blood glucose concentration test results each taken from the patient at a different time over a time period; compute a time-averaged glucose parameter through an averaging of approximated blood glucose concentration test result values as functions of time, the time-averaged glucose parameter being indicative of blood glucose concentration control over the time period; compute a virtual blood hemoglobin parameter through a simulated measurement of a blood hemoglobin through a pre-determined formula correlating an average of time-based weighted blood glucose concentration test results and the blood hemoglobin, the virtual blood hemoglobin parameter being indicative of blood glucose concentration control over an extended time period encompassing the time period; compute a lability factor parameter through a ratio of a standard deviation of a variance of the blood glucose concentration test results to the approximated blood glucose concentration test result values average, the lability factor parameter being indicative of a variability in blood glucose concentration over the time period; and provide the time-averaged glucose parameter, the virtual blood hemoglobin parameter, and the lability factor parameter. - View Dependent Claims (9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19)
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20. A computer-usable medium providing computer readable instructions for execution by a processor to perform a method comprising:
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approximating a plurality of blood glucose concentration test result values as functions of time from consecutive ones of a plurality of blood glucose concentration test results; computing a time averaged glucose value as a first indicator by averaging the approximated blood glucose concentration test result values over the time period; applying a time-based weight to each of the blood glucose concentration test results by multiplying each of the blood glucose concentration test results by a respective coefficient; computing a weighted average by averaging the time-based weighted blood glucose concentration test results; computing a simulated measurement of a blood hemoglobin as a second indicator by correlating with a pre-determined formula the weighted average of the time-based weighted blood glucose concentration test results and the blood hemoglobin; computing a variance of the blood glucose concentration test results; computing a standard deviation of the variance of the blood glucose concentration test results; computing a ratio of the standard deviation to the time averaged glucose value to give a third indicator representing variability of blood glucose concentration over the time period; and providing the first, second, and third indicators.
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Specification