Novel biotinylated compositions
First Claim
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1. A composition comprising a scaffold conjugated to at least one biotin moiety and at least one nucleic acid based therapeutic agent.
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Abstract
Novel biotinylated composition comprising a nucleic acid, e.g. siRNA, that are useful for targeting therapeutic and imaging agents to sites of infection and tumors are disclosed.
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28 Claims
- 1. A composition comprising a scaffold conjugated to at least one biotin moiety and at least one nucleic acid based therapeutic agent.
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11. The composition of
FIG. 2 , wherein at least two of the potential biotinylation sites comprise a biotin.
Specification