Axon Regeneration with PKC Inhibitors
First Claim
1. A method for promoting regenerative growth of an adult mammalian central nervous system neuron axon subject to growth inhibition by endogenous, myelin growth repulsion factors, the method comprising the steps of delivering to the axon a therapeutically effective amount of a specific inhibitor of protein kinase C, whereby regenerative growth of the axon is promoted;
- and detecting a resultant promotion of the regenerative growth of the axon.
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Accused Products
Abstract
Regenerative growth of an adult mammalian central nervous system neuron axon subject to growth inhibition by endogenous, myelin growth repulsion factors is promoted by delivering to the axon a therapeutically effective amount of a specific inhibitor of protein kinase C, whereby regenerative growth of the axon is promoted and a resultant promotion of the regenerative growth of the axon is detected.
5 Citations
20 Claims
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1. A method for promoting regenerative growth of an adult mammalian central nervous system neuron axon subject to growth inhibition by endogenous, myelin growth repulsion factors, the method comprising the steps of delivering to the axon a therapeutically effective amount of a specific inhibitor of protein kinase C, whereby regenerative growth of the axon is promoted;
- and detecting a resultant promotion of the regenerative growth of the axon.
- View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15)
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16. An implantable device for promoting regenerative growth of an adult mammalian central nervous system neuron axon subject to growth inhibition by endogenous, myelin growth repulsion factors, the device comprising a nerve guide tube containing nerve guiding filaments and loaded with a premeasured, discrete and contained amount of a specific inhibitor of protein kinase C, and specifically adapted for implementing a method comprising the steps of delivering locally to the axon a therapeutically effective amount of the inhibitor, whereby regenerative growth of the axon is promoted;
- and detecting a resultant promotion of the regenerative growth of the axon.
- View Dependent Claims (17, 18, 19)
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20. A kit comprising an implantable device for promoting regenerative growth of an adult mammalian central nervous system neuron axon subject to growth inhibition by endogenous, myelin growth repulsion factors, the device comprising a nerve guide tube containing nerve guiding filaments and loaded with premeasured, discrete and contained amounts of a specific inhibitor of protein kinase C, and specifically adapted for implementing a method comprising the steps of delivering locally to the axon a therapeutically effective amount of the inhibitor, whereby regenerative growth of the axon is promoted;
- and detecting a resultant promotion of the regenerative growth of the axon, and printed or electronic instructions describing the method.
Specification
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- Resources
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Current AssigneeChildren's Medical Center Corporation
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Original AssigneeChildren's Medical Center Corporation
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InventorsSivasankanan, Rajeev, He, Zhigang, Koprivica, Vuk
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Application NumberUS12/467,493Publication NumberTime in Patent OfficeDaysField of SearchUS Class Current424/423CPC Class CodesA61K 31/22 of acyclic acids, e.g. prav...A61K 31/496 Non-condensed piperazines c...A61K 31/5415 ortho- or peri-condensed wi...A61K 38/005 Enzyme inhibitors protease ...
