Injectable Combination Therapy for Eye Disorders
First Claim
1. A method of treating an eye disorder characterized by macular degeneration, CNV, or RNV comprising the step of:
- administering effective amounts of first and second therapeutic agents to the subject'"'"'s eye in a single procedure, wherein the first therapeutic agent provides rapid improvement in the condition of the subject'"'"'s eye and the second therapeutic agent is administered as a sustained release formulation of the second therapeutic agent.
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Abstract
The present invention provides composition, methods, and articles of manufacture for treating an eye disorder, e.g., a disorder characterized by macular degeneration, choroidal neovascularization, or retinal neovascularization. One method of the invention comprises the step of: administering first and second therapeutic agents to the subject'"'"'s eye in a single procedure, wherein the first therapeutic agent provides rapid improvement in the condition of the subject'"'"'s eye and the second therapeutic agent is administered as a sustained release formulation of the second therapeutic agent. For example, the first and second therapeutic agents are administered by intravitreal injection. The first therapeutic agent may be dissolved in a liquid medium located in the syringe and the sustained formulation of the second therapeutic agent may comprise an ocular implant or plurality of particles located in the needle. The therapeutic agents may be selected from the group consisting of angiogenesis inhibitors and complement inhibitors.
98 Citations
65 Claims
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1. A method of treating an eye disorder characterized by macular degeneration, CNV, or RNV comprising the step of:
- administering effective amounts of first and second therapeutic agents to the subject'"'"'s eye in a single procedure, wherein the first therapeutic agent provides rapid improvement in the condition of the subject'"'"'s eye and the second therapeutic agent is administered as a sustained release formulation of the second therapeutic agent.
- View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31)
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32. A method of treating an eye disorder characterized by macular degeneration, CNV, or RNV comprising the step of:
- administering first and second compositions to the subject'"'"'s eye in a single procedure, wherein the first composition comprises an angiogenesis inhibitor or complement inhibitor that provides rapid improvement in the condition of the subject'"'"'s eye and the second composition comprises a sustained release formulation comprising an angiogenesis inhibitor or a complement inhibitor.
- View Dependent Claims (33, 34, 35, 36, 37, 38, 39, 40, 41)
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42. A method of administering first and second therapeutic agents to the eye of a subject comprising:
- injecting (i) a solution or suspension containing the first therapeutic agent and (ii) a solid ocular implant, plurality of particles, or gel-forming composition containing the second therapeutic agent into the subject'"'"'s eye in a single injection procedure.
- View Dependent Claims (43, 44, 45, 46, 47, 48, 49)
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50. An article of manufacture comprising (i) a first therapeutic agent effective for treating an eye disorder;
- and (ii) a needle containing a second therapeutic agent.
- View Dependent Claims (51, 52, 53, 54, 55, 56, 57, 60, 61)
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58. An article of manufacture comprising (i) a first therapeutic agent effective for treating an eye disorder;
- (ii) a second therapeutic agent effective for treating an eye disorder, wherein each therapeutic agent is contained in an individual syringe.
- View Dependent Claims (59)
- 62. A needle and syringe assembly, wherein the needle contains a sustained release formulation comprising a first therapeutic agent for an eye disorder and the syringe contains a second therapeutic agent for the eye disorder, wherein the second therapeutic agent is dissolved or suspended in a liquid medium.
Specification