Hydrogel composition and method for making the same
First Claim
1. A hydrogel composition comprising water, a first crosslinked polymer, and a second crosslinked polymer, wherein the first crosslinked polymer comprises poly(ethylene oxide) and the second crosslinked polymer comprises a hydrophilic polymer other than poly(ethylene oxide), wherein the first crosslinked polymer and the second crosslinked polymer form an interpenetrating network (IPN).
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Abstract
Disclosed is a hydrogel composition comprising water, a first crosslinked polymer, and a second crosslinked polymer, wherein the first crosslinked polymer comprises poly(ethylene oxide) and the second crosslinked polymer comprises a hydrophilic polymer other than poly(ethylene oxide), wherein the first crosslinked polymer and the second crosslinked polymer form an interpenetrating network (IPN). The hydrogel of the present invention has an attractive combination of water absorption and compressive strength. The hydrogel composition finds use as a drug delivery device. The invention also provides a method of preparing such hydrogel composition.
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21 Claims
- 1. A hydrogel composition comprising water, a first crosslinked polymer, and a second crosslinked polymer, wherein the first crosslinked polymer comprises poly(ethylene oxide) and the second crosslinked polymer comprises a hydrophilic polymer other than poly(ethylene oxide), wherein the first crosslinked polymer and the second crosslinked polymer form an interpenetrating network (IPN).
- 6. A drug delivery device comprising a hydrogel composition and an active ingredient dispersed or dissolved in the hydrogel composition, wherein the hydrogel composition comprises water, a first crosslinked polymer, and a second crosslinked polymer, wherein the first crosslinked polymer comprises poly(ethylene oxide) and the second crosslinked polymer comprises a hydrophilic polymer other than poly(ethylene oxide), wherein the first crosslinked polymer and the second crosslinked polymer form an interpenetrating network (IPN).
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8. A method for producing a hydrogel composition comprising water, a first crosslinked polymer, and a second crosslinked polymer, wherein the first crosslinked polymer comprises poly(ethylene oxide) and the second crosslinked polymer comprises a hydrophilic polymer other than poly(ethylene oxide), wherein the first crosslinked polymer and the second crosslinked polymer form an interpenetrating network (IPN), said method comprising:
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(a) providing a compression mold having an internal volume; (b) filling at least a portion of the internal volume of the compression mold with polyethylene oxide; (c) heat-compacting the polyethylene oxide within the compression mold to form a consolidated body therefrom; (d) irradiating at least a portion of the consolidated body to crosslink at least a portion of the polyethylene oxide contained within the consolidated body; (e) hydrating the consolidated body from (d); (f) drying the hydrated consolidated body from (e) by lyophilization, vacuum, or heat/vacuum to obtain a foam structure; (g) imbibing the foam structure from (f) with a composition comprising water and/or polar solvent, a monomer corresponding to the second crosslinked polymer and a hydrophilic crosslinking agent to obtain a composite body; (h) polymerizing the monomer and the hydrophilic crosslinking agent contained in the composite body; and (i) hydrating the composite body from (h) to obtain the hydrogel composition. - View Dependent Claims (9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21)
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Specification