×

ISOSORBIDE DERIVATIVES AND THEIR USE AS FLAVOR MODIFIERS, TASTANTS, AND TASTE ENHANCERS

  • US 20090220662A1
  • Filed: 03/03/2009
  • Published: 09/03/2009
  • Est. Priority Date: 03/03/2008
  • Status: Active Grant
First Claim
Patent Images

1. A compound having structural formula (I) or the salt, solvate, ester, or N-oxide thereof, wherein:

  • A is aryl, heteroaryl, or a covalent bond;

    Y is hydrogen, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkylnyl, heteroalkyl, substituted heteroalkyl, aryl, substituted aryl, arylalkyl, substituted arylalkyl, arylalkenyl, substituted arylalkenyl, heteroaryl, substituted heteroaryl, heterocyclyl, substituted heterocyclyl, heteroarylalkyl, substituted heteroarylalkyl, heterocyclylalkyl, substituted heterocyclylalkyl, carbocyclyl, substituted carbocyclyl, acyl, halo, —

    CN, —

    NO2, —

    OR1, —

    S(O)R1, —

    S(O)2R1, —

    OC(O)R1, —

    N(R1)C(O)R2, —

    NR1R2, —

    C(O)NR1R2, —

    C(O)OR1, —

    S(O)2NR1R2, —

    COR1, —

    N(R1)S(O)2R2, —

    SR1, —

    C(R1R2R6), —

    C(S)—

    R1, —

    C(═

    NR2)—

    R1, —

    N(R1)—

    C(═

    N—

    OR2)R6, —

    N(R1)C(S)NR2R6, —

    C(═

    N—

    OR1)R2, —

    C(═

    NR1)—

    NR2R6, —

    N(R1)C(═

    NR2)NR6R7, —

    N(R1)C(S)R2, —

    N(R1)—

    C(O)—

    C(O)R2, —

    C(S)—

    NR1R2, —

    N(R1)C(═

    NR2)OR6, —

    C(═

    NR1)O—

    NR2R6, —

    N(R1)N(R2)C(O)OR6, —

    N(R1)C(O)OR2, —

    N(R1)C(O)NR2R6, —

    N(R1)—

    C(O)—

    C(O)—

    NR2R6, —

    C(O)—

    C(O)—

    NR1R2, —

    P(O)(OR1)(OR2), —

    P(O)(OR1)(R2), or —

    P(O)R1R2;

    X is —

    O—

    , —

    S—

    , —

    S(O)—

    , —

    S(O)2

    , —

    C(R3R4)—

    , —

    C(O)—

    , —

    C(S)—

    , —

    C(═

    NR3)—

    , —

    C(O)O—

    , —

    N(R3)—

    , —

    OC(O)—

    , —

    N(R3)C(O)—

    , —

    C(O)N(R3)—

    , —

    N(R3)—

    C(═

    N—

    OR4)—

    , —

    C(═

    N—

    OR3)—

    , —

    C(═

    NR3)—

    NR4

    , —

    N(R3)C(S)N(R4)—

    R5, —

    N(R3)C(O)N(R4)—

    R5, —

    N(R3)C(═

    NR4)—

    , —

    N(R3)C(S)—

    , —

    N(R3)—

    C(O)—

    C(O)—

    , —

    C(S)—

    N(R3)—

    , —

    N(R3)S(O)2

    , —

    S(O)2

    N(R3)—

    , —

    N(R3)C(═

    NR4)O—

    , —

    C(═

    NR4)O—

    N(R3)—

    , —

    N(R3)—

    C(═

    NR4)—

    N(R5)—

    , —

    N(R3)N(R4)C(O)O—

    , —

    N(R3)C(O)O—

    , —

    N(R3)C(O)N(R4)—

    , —

    N(R3)—

    C(O)—

    C(O)—

    NR4

    , —

    C(O)—

    C(O)—

    NR4

    , —

    P(O)(OR3)—

    , or —

    P(O)R3

    ;

    Z is alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkylnyl, heteroalkyl, substituted heteroalkyl, aryl, substituted aryl, arylalkyl, substituted arylalkyl, arylalkenyl, substituted arylalkenyl, heteroaryl, substituted heteroaryl, heterocyclyl, substituted heterocyclyl, heteroarylalkyl, substituted heteroarylalkyl, heterocyclylalkyl, substituted heterocyclylalkyl, carbocyclyl, or substituted carbocyclyl;

    R1, R2, R3, R4, R5, R6, and R7 are each independently hydrogen, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkylnyl, heteroalkyl, substituted heteroalkyl, aryl, substituted aryl, arylalkyl, substituted arylalkyl, arylalkenyl, substituted arylalkenyl, heteroaryl, substituted heteroaryl, heterocyclyl, substituted heterocyclyl, carbocyclyl, substituted carbocyclyl, heteroarylalkyl, or substituted heteroarylalkyl; and

    with the following provisos;

    (a) when A is triazole or tetrazole;

    then —

    X-Z is not —

    O-alkyl, —

    O-acyl, or sulfonamido;

    (b) when A is tetrazole, and Z is cyclohexyl;

    then X is not —

    NH—

    C(O)—

    , —

    NH—

    C(O)—

    NH—

    ; and

    (c) when A is a covalent bond, then Y is not hydrogen.

View all claims
  • 1 Assignment
Timeline View
Assignment View
    ×
    ×