THERMOCYCLER AND SAMPLE PORT
First Claim
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1. A thermocycler comprising a plurality of nested heat exchangers for independently maintaining a predetermined temperature thereby to define a corresponding plurality of temperature zones;
- said heat exchangers adapted to receive a reaction tube such that said reaction tube is in heat transfer communication with said heat exchangers, whereby a fluid passing through a reaction tube engaged with said heat exchangers passes cyclically through the temperature zones.
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Abstract
The invention relates to continuous flow systems, in particular thermocyclers for the automated and continuous cycling of fluid between a plurality of temperature zones in the amplification of nucleic acids. The invention also relates to an improved sample port for introducing a volume of a liquid sample into a continuous flow system.
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Citations
19 Claims
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1. A thermocycler comprising a plurality of nested heat exchangers for independently maintaining a predetermined temperature thereby to define a corresponding plurality of temperature zones;
- said heat exchangers adapted to receive a reaction tube such that said reaction tube is in heat transfer communication with said heat exchangers, whereby a fluid passing through a reaction tube engaged with said heat exchangers passes cyclically through the temperature zones.
- View Dependent Claims (2, 3, 4, 15, 16, 17, 18, 19)
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5. A sample port for introducing a volume of a liquid sample into a fluid carrier stream flowing through a continuous flow tube having an outlet and a common inlet into which said carrier stream and said liquid sample are both introduced, said port comprising:
- a reservoir for continuously supplying said inlet with said fluid carrier, said reservoir adapted to maintain a substantially constant level of fluid carrier above said inlet and fluidly engageable with said inlet of said continuous flow tube such that, in use, said fluid carrier stream and said liquid sample are drawn through said continuous flow tube when said reservoir is at substantially atmospheric pressure and when said fluid carrier is chosen such that its properties are sufficient to maintain the physical shape of the liquid sample introduced into said carrier.
- View Dependent Claims (6, 7, 8, 9, 10, 11, 12, 13, 14)
Specification