COMPOSITIONS AND METHODS FOR MODULATING CELL DIFFERENTIATION
First Claim
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1. A method for inhibiting the differentiation of a progenitor cell, comprising treating the progenitor cell with a composition comprising an effective amount of an insulin-like growth factor (IGF-1) E-domain peptide together with at least one of a pharmaceutically acceptable carrier, excipient or adjuvant, wherein the composition inhibits cell differentiation.
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Abstract
Compositions and methods are described for using the Ea4-peptide of pro-IGF-I or human Eb-peptide of pro-IGF-I to inhibit hematopoiesis and to induce differentiation of neuroblastoma cells and neuronal stem cells.
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16 Claims
- 1. A method for inhibiting the differentiation of a progenitor cell, comprising treating the progenitor cell with a composition comprising an effective amount of an insulin-like growth factor (IGF-1) E-domain peptide together with at least one of a pharmaceutically acceptable carrier, excipient or adjuvant, wherein the composition inhibits cell differentiation.
- 8. A method for promoting the differentiation of a neuronal progenitor cell, comprising treating a neuronal progenitor cell with a composition comprising an effective amount of an E-domain peptide together with at least one of a pharmaceutically acceptable carrier, excipient or adjuvant, wherein the composition promotes differentiation of the neuronal progenitor cell.
- 14. A method for the suppression of the malignant growth of a neuroblastoma cell comprising, treating a neuroblastoma cell with an effective amount of an E-domain peptide together with at least one of a pharmaceutically acceptable carrier, excipient or adjuvant, wherein the composition promotes neuroblastoma cell differentiation.
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