Cancer Diagnostic Panel

• US 20090221445A1
• Filed: 01/29/2008
• Published: 09/03/2009
• Est. Priority Date: 03/29/2002
• Status: Abandoned Application

• Current Assignee: Yixin Wang
• Original Assignee: Yixin Wang
• Inventors: Wang, Yixin
• Application Number:
  US12/021,439
• Publication Number:
  US 20090221445A1
• Time in Patent Office: Days
• US Class Current: 506/17
• CPC Class Codes: C12Q 1/6886 for cancer immunoassay for cancer G01N33/574
• CPC Class Codes: C12Q 2600/112 Disease subtyping, staging or classification
• CPC Class Codes: C12Q 2600/118 Prognosis of disease development
• CPC Class Codes: C12Q 2600/136 Screening for pharmacological compounds
• CPC Class Codes: C12Q 2600/158 Expression markers

Abstract

A method of diagnosing cancer by identifying differential modulation of each gene (relative to the expression of the same genes in a normal population) in a combination of genes selected from two groups of genes.

Gene expression portfolios and kits for employing the method are further aspects of the invention.

Claims

1. An assay having a portfolio comprising isolated nucleic acid sequences, their complements, or portions thereof of a combination of genes selected from the group consisting of Seq. ID. No. 1-30, Seq. ID No. 32, Seq. ID No. 34 and Seq. ID No. 98.

2. The assay portfolio of claim 1 in a matrix suitable for identifying the differential expression of the genes contained therein.

3. The assay of claim 2 wherein said matrix is employed in a microarray.

4. The assay of claim 3 wherein said microarray is a cDNA microarray.

5. The assay of claim 3 wherein said microarray is an oligonucleotide microarray.

6. An assay having a portfolio comprising isolated nucleic acid sequences, their complements, or portions thereof of a combination of genes selected from the group consisting of Seq. ID. No. 32-67, Seq. ID No. 69, and Seq. ID No. 98-100.

7. The assay of claim 6 in a matrix suitable for identifying the differential expression of the genes contained therein.

8. The assay of claim 7 wherein said matrix is employed in a microarray.

9. The assay of claim 8 wherein said microarray is a cDNA microarray.

10. The assay of claim 8 wherein said microarray is an oligonucleotide microarray.

11. A kit for diagnosing cancer comprising reagents for the detection of the expression of a combination of genes selected from the group consisting of Seq. ID. No. 1-30, Seq. ID No. 32, Seq. ID No. 34 and Seq. ID No. 98.

12. The kit of claim 11 further comprising reagents for conducting a microarray analysis.

13. The kit of claim 11 further comprising a medium through which nucleic acid sequences within said genes, their compliments, or portions thereof are assayed.

14. The kit of claim 13 wherein said medium is a microarray.

15. The kit of claim 11 further comprising instructions.

16. A kit for diagnosing cancer comprising reagents for the detection of the expression of genes selected from the group consisting of Seq. ID. No.32-67, Seq. ID No. 69, and Seq. ID No. 98-100.

17. The kit of claim 16 further comprising reagents for conducting a microarray analysis.

18. The kit of claim 16 further comprising a medium through which nucleic acid sequences within said genes, their compliments, or portions thereof are assayed.

19. The kit of claim 18 wherein said medium is a microarray.

20. The kit of claim 19 further comprising instructions.