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METHOD OF TREATING COGNITIVE IMPAIRMENT

  • US 20090221554A1
  • Filed: 02/28/2008
  • Published: 09/03/2009
  • Est. Priority Date: 02/28/2008
  • Status: Active Application
First Claim
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1. A method of treating cognitive impairment, comprising administering to a subject in need thereof a therapeutic agent for neurodegenerative disease and a heterocyclic compound represented by the following general formula (I):

  • whereinthe structural unit having the general formula (II);

    is one or more structural units selected from multiple types of structural units having the general formula (III);

    R1 and R2 each are one or more functional groups independently selected from the group consisting of a hydrogen atom, halogen atom, hydroxy group, amino group, acetylamino group, benzylamino group, trifluoromethyl group, C1-C6 alkyl group, C1-C6 alkoxy group, and —

    O—

    (CH2)n

    R5 (R5 is a vinyl group, C3-C6 cycloalkyl group, or phenyl group, and n is 0 or

         1);

    R3 and R4 each are one or more functional groups independently selected from the group consisting of a hydrogen atom, C1-C6 alkyl group, C3-C8 cycloalkyl group, and —

    CH(R7)—

    R6;

    alternatively, R3 and R4 together form a spiro ring having the general formula (IV);

    said R6 is one or more functional groups selected from the group consisting of a vinyl group, ethinyl group, phenyl (which may be substituted by a C1-C6 alkyl group, C1-C6 alkoxy group, hydroxy group, 1 or 2 halogen atoms, di C1-C6 alkylamino group, cyano group, nitro group, carboxy group, or phenyl group), phenethyl group, pyridyl group, thienyl group, and furil group;

    said R7 is a hydrogen atom or C1-C6 alkyl group;

    in the general formula (IV), the structural unit B is one or more structural units selected from multiple types of structural units having the general formula (V);

    said structural unit B binds at a position marked by * in the general formula (V) to form a spiro ring; and

    R8 is one or more functional groups selected from the group consisting of a hydrogen atom, halogen atom, hydroxy group, C1-C6 alkoxy group, cyano group, and trifluoromethyl group;

    a hydrate thereof, a solvate thereof or a pharmaceutically acceptable salt thereof wherein therapeutic agent for a neurodegenerative disease and said heterocyclic compound having formula (I) are administered in amounts effective to treat cognition impairment.

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