Motor training with brain plasticity

• US 20090221928A1
• Filed: 08/18/2005
• Published: 09/03/2009
• Est. Priority Date: 08/25/2004
• Status: Active Grant

• Current Assignee: Motorola, Inc. (Motorola Solutions, Inc.)
• Original Assignee: Motorola, Inc. (Motorola Solutions, Inc.)
• Inventors: Einav, Omer, Faran, Samuel, Korenman, Ernesto, Mahoney, Richard M.
• Granted Patent: US 8,938,289 B2
• Time in Patent Office: Days
• US Class Current: 600/544
• CPC Class Codes: A61B 5/11 Measuring movement of the entire body or parts thereof, e.g. head or hand tremor, mobility of a limb for measuring pulse A61B5/02 ;A61B5/1038 takes precedence; motion detection to correct for motion artifacts in physiological signals A61B5/721
• CPC Class Codes: A61B 5/16 Devices for psychotechnics using teaching or educational appliances G09B1/00 - G09B7/00; Testing reaction times ; Devices for evaluating the psychological state
• CPC Class Codes: A61B 5/165 Evaluating the state of mind, e.g. depression, anxiety
• CPC Class Codes: A61B 5/375 using biofeedback
• CPC Class Codes: A61B 5/377 using evoked responses
• CPC Class Codes: A61B 5/378 Visual stimuli
• CPC Class Codes: A61B 5/38 Acoustic or auditory stimuli
• CPC Class Codes: A61B 5/389 Electromyography [EMG]
• CPC Class Codes: A61B 5/4076 Diagnosing or monitoring particular conditions of the nervous system A61B5/4821, A61B5/4824 take precedence
• CPC Class Codes: A61B 5/486 Bio-feedback A61B5/375 takes precedence
• CPC Class Codes: A61H 1/02 Stretching or bending or torsioning apparatus for exercising
• CPC Class Codes: A61H 2230/10 Electroencephalographic signals
• CPC Class Codes: A61H 2230/25 Blood flowrate, e.g. by Doppler effect
• CPC Class Codes: A61H 2230/62 Posture
• CPC Class Codes: A61H 23/00 Percussion or vibration massage, e.g. using supersonic vibration; Suction-vibration massage; Massage with moving diaphragms apparatus for passive exercising A61H1/00; generating or transmitting mechanical vibrations in general B06B

Abstract

A rehabilitation device, comprising a movement element capable of controlling at least one motion parameter of a portion of a patient; a brain monitor which generates a signal indicative of brain activity; and circuitry including a memory having stored therein rehabilitation information and which inter-relates said signal and movement of said movement element as part of a rehabilitation process which utilizes said rehabilitation information.

Claims

1. A rehabilitation device, comprising:

a movement element capable of controlling at least one motion parameter of a portion of a patient;

a brain monitor which generates a signal indicative of brain activity; and

circuitry including a memory having stored therein rehabilitation information and which inter-relates said signal and movement of said movement element as part of a rehabilitation process which utilizes said rehabilitation information and wherein said circuitry is adapted to change at least one motion parameter responsive to said signal.

2. A device according to claim 1, wherein said portion is a limb.

3. A device according to claim 1, wherein said circuitry controls said movement element.

4. A device according to claim 1, wherein said circuitry controls at least one of the direction and location of a movement or a reach point.

5. A device according to claim 3, wherein said circuitry controls at least one of resistance to movement, speed and movement mode.

6. A device according to claim 1, wherein said circuitry measures at least one parameter of motion of said movement element.

7. A device according to claim 6, wherein said circuitry measures at least one of force, movement vector and speed of said movement.

8. A device according to claim 1, wherein said rehabilitation information comprises a rehabilitation plan.

9. A device according to claim 1, wherein said rehabilitation information comprises a rehabilitation diagnosis.

10. A device according to claim 1, wherein said rehabilitation information comprises at least one template of expected brain-motion relationship.

11. A device according to claim 1, wherein said circuitry is adapted to generate an expected motion based on said signal.

12. A device according to claim 1, wherein said circuitry is adapted to generate an expected brain activity based on movement of said movement element.

13. A device according to claim 1, wherein said circuitry is adapted to compare said signal to said rehabilitation information.

14. A device according to claim 1, wherein said circuitry is adapted to compare rehabilitation improvements of said patient to trends in said rehabilitation information.

17. A device according to claim 1, wherein said circuitry is adapted to detect an intent to move of said patient and provide control of said movement element in response thereto.

18. A device according to claim 1, wherein said circuitry is adapted to detect a readiness to move and provide control of said movement element in response thereto.

19. A device according to claim 1, wherein said circuitry is adapted to change a signal processing of said signal responsive to a detection of movement or lack thereof.

20. A device according to claim 1, wherein said brain monitor comprises an EEG monitor.

21. A device according to claim 1, wherein said brain monitor comprises a blood flow measuring device.

22. A device according to claim 1, wherein said brain monitor comprises an fMRI system.

23. A device according to claim 1, wherein said movement element comprises a robotic manipulator.

24. A device according to claim 1, wherein said movement element comprises a resistive movement element which resists motion in a controllable manner.

25. A device according to claim 1, wherein said movement element is adapted to be capable of substantially unrestricted movement in 3D space over a volume of at least 30 cm in minimum dimension.

26. A device according to claim 1, wherein said movement element is adapted to be selectively coupled and decoupled to at least one type of body portion.

27. A device according to claim 1, wherein said circuitry is adapted to provide cognitive rehabilitation to said patient.

28. A device according to claim 1, wherein said circuitry comprises a memory which stores a rehabilitation progress of said patient.

29. A device according to claim 1, comprising at least two movement elements which said circuitry is configured to identify as being associated with opposite limbs.

82. A device according to claim 1, wherein said at least one motion parameter is a rehabilitation parameter.

15. (canceled)

16. A device according to claim 15, wherein said change is within a time frame of said movement.

30. A method of rehabilitation, comprising:

controlling the motion of at least part of a patient as part of a rehabilitation process; and

measuring brain activity of said patient, in association with said controlling.

31. A method according to claim 30, comprising:

(a) deciding on a desired brain rehabilitation; and

(b) controlling said motion to effect said rehabilitation.

32. A method according to claim 31, wherein said desired rehabilitation comprises cortical reorganization.

33. A method according to claim 30, comprising diagnosing the patient based on said measuring.

34. A method according to claim 33, wherein diagnosing comprises controlling said motion to achieve a plurality of desired motions for said diagnosis.

35. A method according to claim 33, wherein diagnosing comprises generating at least an indication of brain plasticity for said patient.

36. A method according to claim 30, comprising controlling said motion in response to said measuring.

37. A method according to claim 30, comprising controlling said measuring in response to said motion.

38. A method according to claim 30, comprising measuring during said motion.

39. A method according to claim 30, comprising repeating said controlling and said measuring for a same motion at least 10 times.

40. A method according to claim 30, comprising repeating said controlling and said measuring for at least 20 different motions in a same day of rehabilitation.

41. A method according to claim 30, comprising comparing measurements for a healthy side and a paretic side.

42. A method according to claim 30, comprising comparing movements for a healthy side and a paretic side.

43. A method according to claim 30, comprising measuring said motion.

44. A method according to claim 30, comprising measuring a quality of said motion.

45. A method according to claim 30, comprising tracking a progress of said rehabilitation process of said patient based on said measurements.

46. A method according to claim 30, comprising training a patient to control cortical activity using said controlling of motion as feedback.

47. A method of treatment targeting, comprising:

a patient locally activating a brain region; and

applying treatment to said brain region in synchrony to said activation.

48. A method according to claim 47, wherein applying treatment comprises physical rehabilitation which uses said brain region.

49. A method according to claim 47, wherein applying treatment comprises delivering a drug.

50. A method according to claim 47, wherein stimulating said brain region using external means that directly stimulate brain tissue.

51. A method according to claim 47, wherein said locally activating comprises forcing a patient to locally activate a region using a physical exercise.

52. A method according to claim 47, wherein said locally activating comprises detecting local activation of said region.

53. A method of brain monitoring, comprising:

generating brain activity by at least guiding a patient to at least intend to carry out a known physical activity;

first monitoring brain activity using a first brain monitor;

second monitoring said activity using a second brain monitor of a different type;

determining a correspondence between results of said first and said second monitoring;

performing rehabilitation on said patient using said second monitor; and

assessing a brain activity of said patient during said performing utilizing a correspondence between said first monitoring and said second monitoring.

54. A method according to claim 53, wherein said assessing comprises assuming a fixed relationship between said results.

55. A method according to claim 53, wherein said generating comprises generating under computer control.

56. A method according to claim 53, wherein said generating comprises repeating a same at least intent at least 10 times.

57. A method according to claim 53, wherein said second monitoring comprises electrical monitoring.

58. A method according to claim 53, wherein said second monitoring is significantly lower cost than said first monitoring.

59. A method according to claim 53, wherein said first monitoring comprises fMRI.

60. A method of rehabilitation comprising:

(a) reorganizing brain functions; and

(b) after said reorganizing, rehabilitating motor control utilizing said reorganizing.

61. A method according to claim 60, wherein said reorganization comprises reorganizing using a physical manipulation system to provide feedback to a patient.

62. A method of controlling rehabilitation, comprising:

defining a desired dosage of a rehabilitation for a patient, wherein said dosage is defined as a function of patient activity;

monitoring the application of said dosage to the patient using a computerized rehabilitation system.

63. A method according to claim 62, wherein said dosage comprises a dosage of physical exertion.

64. A method according to claim 62, wherein said dosage comprises a dosage of mental exertion.

65. A method according to claim 62, wherein said dosage comprises a dosage of attention.

66. A method according to claim 62, wherein said dosage is defined per a brain region.

67. A method of measuring brain patterns, comprising:

providing repeated movement exercises of a patient, under computer control; and

collecting measurements of brain activity from said repeated movements; and

analyzing said measurements to yield a more precise measurement of brain activity in response to the movement.

68. A method according to claim 67, comprising filtering out bad measurements.

69. A method according to claim 67, comprising programming a BCI using said more precise measurement.

70. A method according to claim 67, comprising analyzing said more precise measurement to diagnose said patient.

71. A method according to claim 70, wherein said diagnosis comprises a quality of brain activity.

72. A method according to claim 71, wherein said diagnosis comprises brain plasticity.

73. A method according to claim 67, comprising analyzing said more precise measurement to close a loop in a rehabilitation process.

74. A method of rehabilitation, comprising:

instructing a person to carry out certain movements while being coupled to a spatial manipulator; and

instructing said spatial manipulator to guide said person to perform an incorrect motion.

75. A method according to claim 74, comprising defining a rotational or translational mapping between said movements and said incorrect movements.

76. A method according to claim 74, comprising measuring a cortical response to said person detecting said incorrect motion.

77. A method of ensuring mental imagery, comprising:

providing instructions to a patient to guide a mental imagery thereof;

measuring movement of a patient in response to said imagery;

comparing said instruction to said motion; and

providing feedback to said patient regarding said imagery.

78. A method according to claim 77, comprising measuring brain activity corresponding to said imagery.

79. A method according to claim 78, comprising comparing said brain activity to brain activity collected during said motion.

80. A method according to claim 77, comprising changing said instruction to prevent habitation of said patient.

81. A method according to claim 77, wherein said instructions comprises instructions while said patient has closed eyes.