Method and apparatus for providing therapeutically effective dosage formulations of lidocaine with and without epinephrine

• US 20090221984A1
• Filed: 03/03/2008
• Published: 09/03/2009
• Est. Priority Date: 03/03/2008
• Status: Abandoned Application

• Current Assignee: Akram Girgis, Steve Thuss
• Original Assignee: Akram Girgis, Steve Thuss
• Inventors: Girgis, Akram, Thuss, Steve
• Application Number:
  US12/074,296
• Publication Number:
  US 20090221984A1
• Time in Patent Office: Days
• US Class Current: 604/416
• CPC Class Codes: A61K 31/167 having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
• CPC Class Codes: A61K 9/0019 Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner non-active ingredients are additionally classified in A61K47/00
• CPC Class Codes: B65D 25/08 with provisions for removing or destroying, e.g. to facilitate mixing of contents

Abstract

An apparatus for providing therapeutically effective mixtures of buffered lidocaine (with and without epinephrine) while simultaneously increasing the shelf life, having a two-chambered medicine vial, in which one chamber isolates up to 20 ml of a lidocaine solution (1% with or without epinephrine) and the other chamber isolates up to 2 ml of sodium bicarbonate (8.4%), with a fracturable wall therebetween such that the wall is fractured by bending or twisting, for mixing the lidocaine and sodium bicarbonate to create a buffered lidocaine for administration in therapeutically effective amounts, and further comprising stopper means, like a rubber stopper, for the insertion of a syringe for extraction of the mixture for administration. Also shown is a method for isolating the components for shelf life and providing mixing for an effective composition.

Claims

1. An apparatus for extending the shelf life of buffered lidocaine for administration in therapeutic amounts, comprising a two-chambered medicine vial, wherein one chamber isolates a lidocaine solution and the other sodium bicarbonate with a fracturable wall therebetween such that the wall is fractured for mixing said lidocaine solution and sodium bicarbonate to create a buffered lidocaine for administration, and further comprising stopper means for the insertion of a syringe for extraction of said mixture for administration.

2. The apparatus of claim 1, wherein said lidocaine solution comprises 1% lidocaine.

3. The apparatus of claim 1, wherein said lidocaine solution further comprises epinephrine.

4. The apparatus of claim 1, wherein said sodium bicarbonate is a granulated powder.

5. The apparatus of claim 1, wherein said sodium bicarbonate is 8.4% in solution.

6. The apparatus of claim 1, wherein said apparatus is of sufficient size to accommodate the mixture of lidocaine to sodium bicarbonate in a ratio of 10:

1.

7. The apparatus of claim 1, wherein said apparatus is of sufficient size to accommodate the mixture of 2 ml of said sodium bicarbonate in 8.4% solution to 20 ml of 1% lidocaine.

8. The apparatus of claim 1, wherein said wall is breached by twisting.

9. The apparatus of claim 1, wherein said wall is breached by bending.

10. A method for administering a therapeutic amount of buffered lidocaine, comprising:

(a) isolating a therapeutic amount of lidocaine in solution and a pH-neutralizing amount of buffering reagent in a single medicine vial having a breachable wall between said amounts of lidocaine and buffering reagent;

(b) breaching said wall;

(c) mixing said lidocaine and said buffering reagent; and

(d) withdrawing a suitable quantity of said mixture for administration.

11. The method apparatus of claim 10, wherein said lidocaine solution comprises 1% lidocaine.

12. The method of claim 10, wherein said lidocaine solution further comprises epinephrine.

13. The method of claim 10, wherein said buffering reagent is sodium bicarbonate.

14. The method of claim 13, wherein said sodium bicarbonate is a granulated powder.

15. The method of claim 13, wherein said sodium bicarbonate is 8.4% in solution.

16. The method of claim 13, wherein the amounts isolated are in ratio of 10:

1, lidocaine to sodium bicarbonate, and preferably 20 ml of 1% lidocaine and 2 ml. of sodium bicarbonate in 8.4% solution.

17. The method of claim 10, wherein said breaching occurs by twisting.

18. The method of claim 10, wherein said breaching occurs by bending.