DYNAMIC ANTHROPOMORPHIC CARDIOVASCULAR PHANTOM

• US 20090226867A1
• Filed: 03/04/2009
• Published: 09/10/2009
• Est. Priority Date: 03/04/2008
• Status: Active Grant

• Current Assignee: Bayer Healthcare LLC (Bayer AG)
• Original Assignee: Medrad Incorporated (Bayer AG)
• Inventors: Yanniello, Michael J., Kalafut, John F., Reilly, David M.
• Granted Patent: US 8,608,484 B2
• Time in Patent Office: Days
• US Class Current: 434/268
• CPC Class Codes: G09B 23/32 with moving parts

Abstract

A cardiovascular flow system includes: a cardiovascular model system, a pump system in fluid connection with the cardiovascular model system, and an ECG simulator in communicative connection with the pump system. The ECG simulator system is adapted to create and transmit a simulated ECG signal. The ECG simulator system uses a signal received from the pump system to adjust the simulated ECG signal transmitted from the ECG simulator system. The cardiovascular flow system further includes an injection port adapted to be placed in fluid connection with an injector to inject at least one fluid into the system.

Claims

1. A cardiovascular flow system, comprising:

a cardiovascular model system,

a pump system in fluid connection with the cardiovascular model system,

an ECG simulator in communicative connection with the pump system, the ECG simulator system being adapted to create and transmit a simulated ECG signal,

the ECG simulator system using a signal received from the pump system to adjust the simulated ECG signal transmitted from the ECG simulator system; and

an injection port adapted to be placed in fluid connection with an injector to inject at least one fluid into the system.

2. The cardiovascular flow system of claim 1 wherein the cardiovascular model system simulates mammalian physiologic hemodynamic parameters.

3. The cardiovascular flow system of claim 2 wherein the cardiovascular model system simulates mammalian anatomy for at least one region of interest.

4. The cardiovascular flow system of claim 3 wherein the at least one region of interest comprises the coronary artery tree and the thoracic aorta.

5. The cardiovascular flow system of claim 4 wherein motion within the region of interest as a result of pulsatile flow of fluid therethrough occurs.

6. The cardiovascular flow system of claim 2 wherein the hemodynamic parameters comprise systolic pressure, diastolic pressure and convective transport of an injected fluid from the injection port to at least one region of interest within the cardiovascular model system.

7. The cardiovascular flow system of claim 1, wherein the ECG system includes a processing system to synchronize to the ECG signal to the signal received from the pump system.

8. The cardiovascular flow system of claim 1, wherein the ECG system includes a controller adapter to adjust timing between the ECG signal and signal received from the pump system.

9. The cardiovascular flow system of claim 7, wherein the pump system includes a sensor adapted to provide the signal from the pump system.

10. The cardiovascular flow system of claim 7, wherein the ECG system interfaces with a scanner to transmit the simulated ECG signal to the scanner.

11. The cardiovascular flow system of claim 1, wherein the cardiovascular model system further comprises a lung sink and a body sink in fluid connection within the cardiovascular model system.

12. The cardiovascular flow system of claim 11, wherein interconnections within the cardiovascular model system are formed to simulate at least one of physiology and anatomy.

13. The cardiovascular flow system of claim 12, wherein the interconnections are selected to simulate physiologic pressure.

14. The cardiovascular flow system of claim 1, further comprising a kidney simulation system in fluid connection with the cardiovascular model system.

15. The cardiovascular flow system of claim 14, wherein the kidney system comprises a first pump system to pump fresh fluid into the cardiovascular model system and a second pump system to pump fluid out of the cardiovascular system.

16. The cardiovascular flow system of claim 15 wherein the kidney simulation system is controlled to control at least one of fluid volume and pressure within the cardiovascular model system.

17. The cardiovascular flow system of claim 1 further comprising a pressure relief system to prevent pressure within the system from exceeding a predetermined pressure.

18. The cardiovascular flow system of claim 17, wherein the pressure relief system is adapted to maintain pressure within the cardiovascular model system within limits of physiologic pressure.

19. The cardiovascular flow system of claim 1, wherein the cardiovascular model system comprises a cardiac vasculature model comprising a pulmonary artery crossing the cardiac anatomy.

20. The cardiovascular flow system of claim 1, further comprising the injector.

21. A method of simulating flow of an injection fluid through a mammalian cardiovascular system, comprising:

providing a cardiovascular model, the cardiovascular model comprising an injection port adapted to be placed in fluid connection with an injector to inject the injection fluid into the cardiovascular model;

pumping fluid through the cardiovascular model;

configuring cardiac output, heart rate, stroke volume in the cardiovascular model;

providing a simulated ECG signal, wherein the ECG signal is synchronized with pumping pulse or pumping pressure;

injecting the injection fluid into the cardiovascular model via the injection port; and

detecting the injection fluid in at least one region of interest within the cardiovascular model.

22. The method of claim 21, wherein the synchronization is based on an aortic pressure.

23. The method of claim 21, further comprising scanning the at least one region of interest of the cardiovascular model with an imaging system to produce an image.

24. The method of claim 23, wherein the injection fluid comprises a contrast medium.

25. The method of claim 21, wherein the cardiovascular model includes a coronary vasculature model, a body sink and a lung sink in fluid connection.

26. The method of claim 25, wherein the coronary vasculature model, the body sink and the lung sink are in fluid connection via tubing adapted to simulate physiological pressures.

31. The cardiovascular flow system of claim 25, wherein the pressure relief system is adapted to maintain pressure within the cardiovascular model system within limits of physiologic pressure.

27. A cardiovascular flow system, comprising:

a cardiovascular model system,

a pump system in fluid connection with the cardiovascular model system,

an injection port adapted to be placed in fluid connection with an injector to inject at least one fluid into the system; and

a kidney system in fluid connection with the cardiovascular model system, the kidney system comprising a first pump system to pump fresh fluid into the cardiovascular model system and a second pump system to pump fluid out of the cardiovascular system.

28. The cardiovascular flow system of claim 27, wherein the first pump system and the second pump system are controlled to prevent fluid volume increase within the cardiovascular model system upon injection of fluid into the cardiovascular model system via the injection port.

29. The cardiovascular flow system of claim 27 wherein the kidney system is controlled to control pressure within the cardiovascular model system.

30. A cardiovascular flow system, comprising:

a cardiovascular model system,

a pump system in fluid connection with the cardiovascular model system,

an injection port adapted to be placed in fluid connection with an injector to inject at least one fluid into the system; and

a pressure relief system to prevent pressure within the cardiovascular model system from exceeding a predetermined pressure.

32. A cardiovascular flow system, comprising:

a cardiovascular model system for simulating anatomy and physiology,

a pump system in fluid connection with the cardiovascular model system,

an ECG simulator in communicative connection with the pump system, the ECG simulator system being adapted to create and transmit a simulated ECG signal,

the ECG simulator system using a signal received from the pump system to adjust the simulated ECG signal transmitted from the ECG simulator system; and

an injection port adapted to be placed in fluid connection with an injector to inject at least one fluid into the system.