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Methods for Screening, Predicting and Monitoring Prostate Cancer

  • US 20090226915A1
  • Filed: 01/06/2009
  • Published: 09/10/2009
  • Est. Priority Date: 01/24/2001
  • Status: Abandoned Application
First Claim
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1. A method for screening or monitoring a patient for prostate cancer, comprising:

  • obtaining a biological sample for the patient;

    detecting within each of the biological sample and a control an expression level of a product of each of from one to four genes consisting of PDZ and LIM5 (SEQ ID NO.

         1), UAP1/AgX1 antigen (SEQ ID NO.

         2), HSPD1/chaperonin (SEQ ID NO.

         3), IMPDH2 (SEQ ID NO.

         5);

    detecting within the biological sample and the control an expression level of a product of a reference gene;

    normalizing the expression level of the product of each of the from one to four genes using the expression level of the product of the reference gene;

    classifying the biological sample as “

    cancer”

    or “

    normal”

    by generating a binary prediction score by combining the normalized expression level of all of the from one to four genes with a bias.

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