CONTROLLED RELEASE DELIVERY SYSTEM FOR NASAL APPLICATION OF NEUROTRANSMITTERS
First Claim
Patent Images
1. A formulation for nasal application comprising:
- (a) at least one active ingredient selected from the groups consisting of a neurotransmitter and a neuromodulator agent;
(b) at least one lipophilic or partly lipophilic carrier;
(c) a compound or a mixture of compounds having surface tension decreasing activity in an amount effective for generating contact of the formulation with a hydrophilic mucous membrane; and
optionally(d) a viscosity-regulating agent.
3 Assignments
0 Petitions
Accused Products
Abstract
This invention relates to a galenical gel formulation for nasal administration of neurotransmitters/neuromodulators such as dopamine, serotonin or pregnenolone and progesterone. The special lipophilic or partly lipophilic system of the invention leads to high bioavailability of the active ingredient in plasma and brain caused by sustained serum levels and/or direct or partly direct transport from nose to the brain.
77 Citations
26 Claims
-
1. A formulation for nasal application comprising:
-
(a) at least one active ingredient selected from the groups consisting of a neurotransmitter and a neuromodulator agent; (b) at least one lipophilic or partly lipophilic carrier; (c) a compound or a mixture of compounds having surface tension decreasing activity in an amount effective for generating contact of the formulation with a hydrophilic mucous membrane; and
optionally(d) a viscosity-regulating agent. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25)
-
-
26. A formulation for nasal application comprising:
-
(a) dopamine or L-DOPA in an amount of about 2% by weight; (b) castor oil in an amount of about 90% by weight; (c) a compound or a mixture of compounds comprising an oleoyl macrogolglyceride or a mixture of oleoyl macroglyverides in an amount of about 4% by weight and having surface tension decreasing activity in an amount effective for generation of contact of the formulation with water; and
optionally(d) colloidal silicon dioxide in an amount of about 4% by weight.
-
Specification