Wound Closure Devices, Methods of Use, and Kits

• US 20090227938A1
• Filed: 10/07/2008
• Published: 09/10/2009
• Est. Priority Date: 03/05/2008
• Status: Abandoned Application

• Current Assignee: Insitu Therapeutics Incorporated
• Original Assignee: Insitu Therapeutics Incorporated
• Inventors: Moshfeghi, Darius, Ryu, WonHyoung, Fasching, Rainer
• Application Number:
  US12/247,003
• Publication Number:
  US 20090227938A1
• Time in Patent Office: Days
• US Class Current: 604/57
• CPC Class Codes: A61B 17/0057 Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect sutures A61B17/04; closing rectum or urethra near body surface A61F2/0009
• CPC Class Codes: A61B 17/068 Surgical staplers , e.g. containing multiple staples or clampsstaplers containing only one staple A61B17/10; magazines or containers for staples A61B17/105; for performing anastomosis A61B17/115; staplers in general B25C5/00
• CPC Class Codes: A61B 2017/00654 entirely comprised between the two sides of the opening
• CPC Class Codes: A61B 2017/0647 having one single leg, e.g. tacks
• CPC Class Codes: A61F 9/0017 implantable in, or in contact with, the eye, e.g. ocular inserts
• CPC Class Codes: A61F 9/00736 Instruments for removal of intra-ocular material or intra-ocular injection, e.g. cataract instruments A61F9/008 takes precedence

Abstract

Provided herein is a wound closure device comprising a plug adaptable to be inserted into an opening formed in two or more tissue layers, one tissue layer transposable relative to a second layer, the plug comprising a material having a first configuration and a second configuration, wherein the plug is adaptable to be inserted into the opening in the first configuration and further adaptable to transition from the first configuration to the second configuration after being inserted into the opening. The wound closure device can be used in cases where ocular surgery has been preformed.

Claims

1. A wound closure device comprising

a plug adaptable to be inserted into an opening formed in two or more tissue layers, one tissue layer transposable relative to a second layer, the plug comprising a material having a first configuration and a second configuration, wherein the plug is adaptable to be inserted into the opening in the first configuration and further adaptable to transition from the first configuration to the second configuration after being inserted into the opening.

2. The wound closure device of claim 1 wherein the material is adaptable to transition between the first configuration and the second configuration after exposure to one or more of an aqueous medium, a change a physical environment, change in temperature, a change of a chemical environment, pH, ion strength, salt concentration, or light.

3. The wound closure device of claim 1 wherein the material is a biocompatible material.

4. The wound closure device of claim 1 wherein the material is selected from at least one of a compressible material, temperature dependent material, shape memory material, a swellable material, or an expandable material.

5. The wound closure device of claim 1 further comprising an anchor adaptable to prevent removal of the wound closure device from a wound.

6. The wound closure device of claim 1 further comprising a handle adaptable to insert the wound closure device in a wound.

7. The wound closure device of claim 1 wherein the device is adaptable to be cut.

8. The wound closure device of claim 7 wherein the device further comprises at least one marker.

9. The wound closure device of claim 1 wherein the device further comprises a drug delivery element.

10. The wound closure device of claim 1 wherein the device is adaptable to be in the first configuration after being subjected to at least one of a physical force, a chemical force, or a mechanical force.

11. The wound closure device of claim 1 wherein the device is adaptable to be inserted into a wound by a device applicator.

12. The wound closure device of claim 11 wherein the device is a pre-cut device.

13. The wound closure device of claim 11 wherein the device is adaptable to be cut by the applicator.

14. The wound closure device of claim 11 wherein the device is adaptable to be inserted through a cannula.

15. The wound closure device of claim 14 wherein the device is adaptable to be inserted into a wound while the cannula is retracted.

16. The wound closure device of claim 15 wherein the device is adaptable to be visualized as it is inserted by the applicator.

17. The wound closure device of claim 1 wherein the device is adaptable to seal a wound.

18. The wound closure device of claim 1 wherein the device is adaptable to facilitate wound in-growth.

19. The wound closure device of claim 1 wherein the device is adaptable to be inserted without relocating the opening.

20. A wound closure device for use after ocular surgery comprising

a plug adaptable to be inserted into an opening formed during ocular surgery, the opening formed in two or more tissue layers, one tissue layer transposable relative to a second layer, the plug comprising a material having a first configuration and a second configuration, wherein the plug is adaptable to be inserted into the opening in the first configuration and further adaptable to transition from the first configuration to the second configuration after being inserted into the opening.

21. The wound closure device of claim 20 wherein the plug is adaptable to transition between the first configuration and the second configuration after exposure to one or more of an aqueous medium, change in temperature, a chemical environment, pH, ion strength, salt concentration, or light.

22. The wound closure device of claim 20 wherein the plug comprises a biocompatible material.

23. The wound closure device of claim 20 wherein the plug is adaptable to be in the first configuration after being subjected to at least one of a physical force, a chemical force, and a mechanical force.

24. The wound closure device of claim 20 wherein the device is adaptable to be inserted without relocating the opening.

25. A method for closing an opening following a vitrectomy comprising:

obtaining access through the conjunctiva and sclera; and

inserting a wound closure device into the conjunctiva and sclera, wherein the opening is formed in two or more layers of tissue, one tissue layer transposable relative to a second layer.

26. The method of claim 25 further comprising the step of cutting the wound closure device.

27. The method of claim 25 further comprising the step of positioning the conjunctiva over the wound closure device.

28. The method of claim 25 wherein the wound closure device comprises a material having a first configuration and a second configuration, wherein the device is adaptable to be inserted into a wound in the first configuration and wherein the material transitions from the first configuration to the second configuration after being inserted into the wound.

29. The method of claim 25 wherein the wound closure device is adaptable to transition between the first configuration and the second configuration after being exposed to one or more of an aqueous medium, change in temperature, a chemical environment, pH, ion strength, salt concentration, or light.

30. The method of claim 25 further comprising the step of inserting a cannula through the conjunctiva and sclera after the obtaining step.

31. The method of claim 30 further comprising the step of removing the cannula after the wound closure device has been inserted through the cannula.

32. The method of claim 30 wherein the removing step further comprises retracting at least a portion of the device while removing the cannula.

33. The method of claim 30 further comprising the step of inserting a catheter through the cannula, wherein the catheter is adaptable to facilitate the insertion of the wound closure device.

34. The method of claim 30 further comprising the step of inserting a guide wire through the cannula, wherein the guide wire is adaptable to facilitate the insertion of the wound closure device.

35. The method of claim 30 further comprising the step of severing the cannula, wherein a portion of the severed cannula is adaptable to facilitate closing the wound.

36. The method of claim 25 wherein the wound closure device comprises a non-solid material.

37. The method of claim 25 wherein the wound closure device comprises a solid material.

38. The method of claim 25 further comprising the step of delivering a drug to the vitreous chamber.

39. A method for closing a wound following a vitrectomy comprising

obtaining access through a portion of a conjunctiva and a sclera through a cannula;

and

inserting a wound closure device through the cannula,

wherein the opening is formed in two or more layers of tissue, one tissue layer transposable relative to a second layer.

40. The method of claim 39 further comprising the step of cutting the wound closure device.

41. The method of claim 39 further comprising the step of covering the device with the conjunctiva.

42. The method of claim 39 wherein the wound closure device comprises a material having a first configuration and a second configuration, wherein the device is adaptable to be inserted into a wound in the first configuration and wherein the material transitions from the first configuration to the second configuration after being inserted into the wound.

43. The method of claim 42 wherein the device transitions from a first configuration to a second configuration after being exposed to one or more of an aqueous medium, change in temperature, a change of a physical environment, a change of a chemical environment, pH, ion strength, salt concentration, or light.

44. The method of claim 39 further comprising the step of removing the cannula after the wound closure device has been inserted through the cannula.

45. The method of claim 44 wherein the wound closure device is adaptable to be partially retracted as the cannula is removed.

46. The method of claim 39 further comprising the step of inserting a catheter through the cannula, wherein the catheter is adaptable to facilitate insertion of the device.

47. The method of claim 39 further comprising the step of inserting a guide wire through the cannula, wherein the guide wire is adaptable to facilitate insertion of the device.

48. The method of claim 39 further comprising the step of severing the cannula, wherein a portion of the severed cannula remains in the eye.

49. The method of claim 48 wherein the step of inserting the wound closure device comprises the use of the portion of the severed cannula remaining in the eye.

50. The method of claim 39 wherein the wound closure device comprises a non-solid material.

51. The method of claim 39 wherein the wound closure device comprises a solid material.

52. A method for closing an indexed wound using a wound closure device comprising

inserting a wound closure device through a wound without causing further trauma to the wound or an area surrounding the wound, the wound closure device having a first configuration and a second configuration, wherein the device is adaptable to be inserted into the wound in the first configuration and wherein the device is adaptable to transition to the second configuration after the device has be inserted into the wound.

53. A method for closing a wound through which a procedure can be performed wherein the wound extends through at least two layers of tissue, the method comprising

a. identifying a position of a wound;

b. inserting a wound closure device into the wound; and

c. closing the wound with the wound closure device,

wherein the wound is formed in two or more layers of tissue, one tissue layer transposable relative to a second layer.

54. The method of claim 53 wherein the wound is an ocular wound.

55. A kit for closing an opening following a vitrectomy procedure comprising

a plug adaptable to be inserted into an opening formed in two or more tissue layers, one tissue layer transposable relative to a second layer, the plug comprising a material having a first configuration and a second configuration, wherein the plug is adaptable to be inserted into the opening in the first configuration and further adaptable to transition from the first configuration to the second configuration after being inserted into the opening.

56. The kit of claim 55 further comprising at least one cannula.

57. The kit of claim 55 further comprising at least one catheter.

58. The kit of claim 55 further comprising at least one guide wire.

59. The kit of claim 55 wherein the wound closure device further comprises a drug eluting segment.

60. The kit of claim 59 wherein the drug eluting segment is preloaded with a drug.

61. The kit of claim 59 wherein the drug eluting segment is a loadable drug eluting segment.

62. The kit of claim 61 further comprising at least one vial containing at least one drug.

63. A kit for closing a wound following a vitrectomy procedure comprising

a plug adaptable to be inserted into an opening formed in two or more tissue layers, one tissue layer transposable relative to a second layer, the plug comprising a material having a first configuration and a second configuration, wherein the plug is adaptable to be inserted into the opening in the first configuration and further adaptable to transition from the first configuration to the second configuration after being inserted into the opening;

and

a plug applicator adaptable to insert the plug.

64. The kit of claim 63 further comprising at least one cannula.

65. The kit of claim 63 further comprising at least one catheter.

66. The kit of claim 63 further comprising at least one guide wire.

67. The kit of claim 63 wherein the wound closure device further comprises a drug eluting segment.

68. The kit of claim 67 wherein the drug eluting segment is preloaded with a drug.

69. The kit of claim 67 wherein the drug eluting segment is a loadable drug eluting segment.

70. The kit of claim 69 further comprising at least one vial containing at least one drug.