METHOD AND PROCESS FOR THE PRODUCTION OF MULTI-COATED RECOGNITIVE AND RELEASING SYSTEMS

• US 20090232857A1
• Filed: 12/04/2008
• Published: 09/17/2009
• Est. Priority Date: 03/12/2007
• Status: Active Grant

• Current Assignee: Board of Regents of the University of Texas System (University of Texas System)
• Original Assignee: Board of Regents of the University of Texas System (University of Texas System)
• Inventors: Peppas, Nicholas A.
• Granted Patent: US 8,821,899 B2
• Time in Patent Office: Days
• US Class Current: 424/401
• CPC Class Codes: A61K 2800/413 Nanosized, i.e. having sizes below 100 nm
• CPC Class Codes: A61K 31/137 Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
• CPC Class Codes: A61K 38/28 Insulins
• CPC Class Codes: A61K 47/34 Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers A61K47/10 takes precedence
• CPC Class Codes: A61K 47/6903 the form being semi-solid, e.g. an ointment, a gel, a hydrogel or a solidifying gel
• CPC Class Codes: A61K 8/0241 Containing particulates characterized by their shape and/or structure see also A61K8/04, A61K8/11, and A61K8/14, further aspects are classified in A61K2800/40 and subcodes
• CPC Class Codes: A61K 8/025 Explicitly spheroidal or spherical shape
• CPC Class Codes: A61K 8/0279 Porous; Hollow
• CPC Class Codes: A61K 8/731 Cellulose; Quaternized cellulose derivatives
• CPC Class Codes: A61K 9/0004 Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
• CPC Class Codes: A61K 9/0014 Skin, i.e. galenical aspects of topical compositions non-active ingredients are additionally classified in A61K47/00; A61K9/0009, A61K9/0021, A61K9/7015, A61K9/7023 take precedence; cosmetic preparations A61K8/00, A61Q; preparations for wound dressings or bandages A61L26/00
• CPC Class Codes: A61K 9/5031 obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
• CPC Class Codes: A61K 9/5073 having two or more different coatings optionally including drug-containing subcoatings
• CPC Class Codes: A61K 9/7007 Drug-containing films, membranes or sheets A61K9/0041, A61K9/0043, A61K9/006, A61K9/0063 take precedence
• CPC Class Codes: A61K 9/7015 Drug-containing film-forming compositions, e.g. spray-on
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
• CPC Class Codes: A61Q 13/00 Formulations or additives for perfume preparations essential oils or perfumes per se C11B9/00
• CPC Class Codes: A61Q 17/005 Antimicrobial preparations
• CPC Class Codes: B82Y 5/00 Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

Abstract

The present invention includes compositions, methods, systems for the controlled delivery of an active agent within a polymeric network upon the binding of a molecule that decreases the structural integrity of the polymeric network at one or more micro- or nanovacuoles.

Claims

1. A composition comprising:

a molecule-imprinted polymeric network comprising a polymer, a micromolecular systems, a hydrogel, a gel or a composite comprising one or more micro- or nanovacuoles or pores, wherein the nanovacuoles recognize a specific molecule and subsequent contact with the molecule creates internal stresses that rupture the polymeric network at the micro-or nanovacuoles.

2. The composition of claim 1, wherein rupture of the polymeric network is due to:

osmosis upon recognition and binding of the molecule leading to rupture due to swelling;

change of the solubility of the polymeric network leading to polymer dissolution;

local temperature changes leading to expansion of the polymeric network and combinations thereof.

3. The composition of claim 1, wherein the composition is loaded with one or more active agents to form an active agent-loaded, molecule-imprinted network.

4. The composition of claim 3, wherein the molecule-imprinted network is imprinted in a carbohydrate polymer of glycosidic type mono-sugar repeative units, galactomannans, pectins, alginates, carrageenans and xanthan gum that are linear or branched, neutral or anionic and combinations thereof.

5. The composition of claim 3, wherein the active agent-loaded, molecule-imprinted network is adapted for pharmaceuticals, medical agents, food components, detergents, bleaches, fabric softeners, fragrances, cosmetic products, air fresheners, room deodorant devices, perfumed substrates, perfumed plastics, pet collars, food and cosmetic applications, hydrocolloids extracted from plants, seaweeds or animal collagen, produced by microbial synthesis, and comprise polysaccharides, proteins, for personal care selected from hair care (shampoos, hair mousses, styling agents);

skin care (body lotions, vitamin e, aloe vera);

bath products (moisture-triggered release products);

body powders;

toilet soap (milled or poured, ionic strength-triggered release), household products selected from laundry care;

paper products;

specialty cleaners (chlorinated cleaners, scouring pads, effervescent toilet bowl cleaner powders);

air fresheners, cosmetics and treatment products selected from lipstick;

eye-liner;

foundation;

base;

blush;

mascara;

eye shadow;

lip liner;

facial powder;

consealer;

facial cream;

make-up remover;

mascara remover;

make-up;

skin treatments, a fragrance selected from cologne;

perfume;

sampling;

antiperspirant;

deodorant;

anti-dandruff shampoos;

athlete foot products and combinations thereof.

6. The composition of claim 3, wherein the active agent-loaded, molecule-imprinted network is encapsulated.

7. The composition of claim 3, wherein the active agent-loaded, molecule-imprinted network is encapsulated and comprises a surfactant, a bleaching agent, a corrosion inhibitor, a sudsing modifier, a fluorescent whitening agent, one or more enzymes, an anti redeposition agent, a color, one or more additives and combinations thereof.

8. The composition of claim 3, wherein the active agent is released upon a change in solubility, pressure, a pH shift, a change in temperature, a temperature increase, enzymatic breakdown, diffusion and combinations thereof.

9. The composition of claim 1, wherein the polymeric recognitive network is formed into one or more layers.

10. The composition of claim 1, wherein the polymeric recognitive network is formed into one or more layers, each of which recognizes one or more different molecules and each of which provides a barrier to the release of one or more different active or inert agents or both.

11. The composition of claim 1, wherein the polymeric recognitive network is formed into a sphere, film, planar, semi-spherical, cylinder, rod, hemispheres, conical, hemi-cylinders and combination thereof.

12. The composition of claim 1, wherein the polymeric recognitive network is at least partially porous.

13. An active agent-loaded, molecule-imprinted polymeric network comprising:

two or more active agent loaded, aggregated polymeric or gel nanoparticles or microparticles comprising micro- or nanovacuoles or micro- or nanopores previously imprinted with a molecule, wherein one or more pre-determined molecules bind specifically to the micro- or nanovacuoles or micro- or nanopores and contact with the molecule creates internal stresses that rupture the network at the micro- or nanovacuoles or micro- or nanopores thereby releasing one or more active agents loaded into the active agent-loaded, molecule-imprinted polymeric network.

14. A method of making a recognitive release system comprising:

selecting one or more molecules for recognition;

forming micro- or nano-vacuoles in a polymeric recognitive network about the one or more molecules;

removing the molecule from the micro- or nano-vacuoles; and

coating one or more active agents with a polymeric recognitive network, wherein the one or more active agents release upon contact by the polymeric recognitive network with its cognate molecule.

15. The method of claim 14, wherein the polymeric recognitive network is formed about a core.

16. The method of claim 14, wherein the polymeric recognitive network is coated into multiple layers.

17. The method of claim 14, wherein the polymeric recognitive network is coated by a Wurster coating method.

18. The method of claim 14, wherein the polymeric recognitive network is further encapsulated in a capsule, caplet, softgel, gelcap, suppository, film, granule, gum, insert, pastille, pellet, troche, lozenge, disk, poultice or wafer.

19. The method of claim 14, wherein the polymeric recognitive network is formed into one or more layers, each of which recognizes one or more different molecules and each of which provides a barrier to the release of one or more different active or inert agents or both.

20. The method of claim 14, wherein the polymeric recognitive network is formed into a sphere, film, planar, semi-spherical, cylinder, rod, hemispheres, conical, hemi-cylinders and combination thereof.

21. The method of claim 14, wherein the polymeric recognitive network is at least partially porous.

22. A method of making a polymeric recognitive network comprising:

selecting one or more targets for recognition;

forming micro- or nano-vacuoles in the polymeric recognitive network about the one or more targets;

embedding within the polymeric recognitive network one or more active agents for release upon dissociation of the polymeric recognitive network; and

removing the targets from the micro- or nano-vacuoles,

wherein subsequent binding of the target to the micro- or nano-vacuoles causes disruption of the polymeric recognitive network and release of the one or more active agents.

23. A method of loading an active agent in a molecule-imprinted network comprising:

mixing the active agent to the molecule-imprinted network at or about room temperature;

heating the mixture to about 40°

C. to swell the molecule-imprinted network, wherein the active agent diffuses into the molecule-imprinted network; and

cooling the mixture to about room temperature, wherein the molecule-imprinted network collapses and traps the active agent within the molecule-imprinted network.

24. The method of claim 23, wherein the active agent-loaded, molecule-imprinted network is adapted for pharmaceuticals, medical agents, food components, detergents, bleaches, fabric softeners, fragrances, cosmetic products, air fresheners, room deodorant devices, perfumed substrates, perfumed plastics, pet collars, food and cosmetic applications, hydrocolloids extracted from plants, seaweeds or animal collagen, produced by microbial synthesis, and comprise polysaccharides, proteins, for personal care selected from hair care (shampoos, hair mousses, styling agents);

skin care (body lotions, vitamin e, aloe vera);

bath products (moisture-triggered release products);

body powders;

toilet soap (milled or poured, ionic strength-triggered release), household products selected from laundry care;

paper products;

specialty cleaners (chlorinated cleaners, scouring pads, effervescent toilet bowl cleaner powders);

air fresheners, cosmetics and treatment products selected from lipstick;

eye-liner;

foundation;

base;

blush;

mascara;

eye shadow;

lip liner;

facial powder;

consealer;

facial cream;

make-up remover;

mascara remover;

make-up;

skin treatments, a fragrance selected from cologne;

perfume;

sampling;

antiperspirant;

deodorant;

anti-dandruff shampoos;

athlete foot products and combinations thereof.

25. The method of claim 23, wherein the molecule-imprinted network comprises a carbohydrate polymer of glycosidic type mono-sugar repeative units, galactomannans, pectins, alginates, carrageenans and xanthan gum that are linear or branched, neutral or anionic and combinations thereof.

26. The method of claim 23, wherein the active agent-loaded, molecule-imprinted network is encapsulated.

27. The method of claim 23, wherein the active agent is released upon a change in solubility, pressure, a pH shift, a change in temperature, a temperature increase, enzymatic breakdown, diffusion and combinations thereof.

28. The method of claim 23, wherein the polymeric recognitive network is formed into one or more layers.

29. The method of claim 23, wherein the polymeric recognitive network is formed into one or more layers, each of which recognizes one or more different molecules and each of which provides a barrier to the release of one or more different active or inert agents or both.

30. The method of claim 23, wherein the polymeric recognitive network is formed into a sphere, film, planar, semi-spherical, cylinder, rod, hemispheres, conical, hemi-cylinders and combination thereof.

31. The method of claim 23, wherein the polymeric recognitive network is at least partially porous.