ARTIFICIAL MICROVASCULAR DEVICE AND METHODS FOR MANUFACTURING AND USING THE SAME
First Claim
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1. An artificial microvascular device, comprising:
- a polymer scaffold defining a first channel therein, said first channel having at least one distensible wall.
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Abstract
Artificial microvascular devices may include a polymer scaffold that defines a channel with a distensible wall.
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Citations
35 Claims
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1. An artificial microvascular device, comprising:
a polymer scaffold defining a first channel therein, said first channel having at least one distensible wall. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17)
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18. An artificial microvascular device, comprising:
a polymer scaffold defining first and second channels therein, at least part of the first channel being axially parallel to at least part of the second channel, and wherein the first and second channels are separated by a fenestrated wall. - View Dependent Claims (19, 20, 21, 22, 23, 24)
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25. A method of manufacturing an artificial microvascular device, comprising:
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(a) applying a moldable polymer to a master mold that comprises at least one inverse channel; (b) curing and removing the polymer, thereby creating a stamp having an open channel; and (c) coupling a polymer sheet to the stamp such as to cover the open side of the channel, wherein the polymer sheet is sufficiently thin so as to render a channel wall that it forms distensible. - View Dependent Claims (26, 27, 28, 29)
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30. A method of testing a response of an artificial microvascular device to a mechanical stimulus, the method comprising:
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(a) providing an artificial microvascular device comprising a polymer scaffold that defines a first channel therein, said first channel having at least one distensible wall and further having cells plated therein; and (b) observing a response of the distensible wall to a mechanical stimulus. - View Dependent Claims (31, 32, 33, 34, 35)
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Specification