APPARATUS AND METHODS OF OPTIMIZING ATRIOVENTRICULAR PACING DELAY INTERVALS

• US 20090234411A1
• Filed: 03/13/2008
• Published: 09/17/2009
• Est. Priority Date: 03/13/2008
• Status: Active Grant

• Current Assignee: Medtronic Incorporated (Medtronic Plc)
• Original Assignee: Medtronic Incorporated (Medtronic Plc)
• Inventors: Mullen, Thomas J., Sambelashvili, Aleksandre T.
• Granted Patent: US 7,941,218 B2
• Time in Patent Office: Days
• US Class Current: 607/25
• CPC Class Codes: A61N 1/3627 for treating a mechanical deficiency of the heart, e.g. congestive heart failure or cardiomyopathy
• CPC Class Codes: A61N 1/36585 controlled by two or more physical parameters
• CPC Class Codes: A61N 1/3682 with a variable atrioventricular delay
• CPC Class Codes: A61N 1/3684 for stimulating the heart at multiple sites of the ventricle or the atrium
• CPC Class Codes: A61N 1/36843 Bi-ventricular stimulation
• CPC Class Codes: A61N 1/3752 Details of casing-lead connections
• CPC Class Codes: A61N 1/3756 Casings with electrodes thereon, e.g. leadless stimulators

Abstract

Provided herewith are methods and apparatus for optimizing an atrioventricular (AV) pacing delay interval based upon ECG-based optimization is calculated as a linear function of P-wave duration, sensed PR (intrinsic) interval, sensed or paced QRS duration and heart rate. Since the relationship among these parameters is linear, once the coefficients are solved (which can be any value, including null) with reference to a known optimized AV interval (AVopt) such as from an echocardiographic study, an AVopt value can be dynamically adjusted in an ambulatory subject. The various combinations of values can be loaded into a look up table or calculated automatically. And, since some of the parameters do not typically change much over time they can be determined acutely and fed into the equation while the other values can be measured frequently. The parameter values can be measured by an implantable medical device such as a dual- or triple-chamber pacemaker.

Claims

1. A method of adjusting an operating atrio-ventricular (AV) interval in a cardiac pacing therapy delivery device, comprising:

measuring the following temporal cardiac parameters of a subject'"'"'s heart;

a P-wave duration (PWd) value, a sensed intrinsic atrioventrical (PR) interval, a sensed or paced QRS duration (QRSd) value, a heart rate (HR) for at least one cardiac cycle;

calculating an optimized AV interval (AVopt) as a linear function of the sensed PWd value, the sensed PR interval value, the sensed or paced QRSd value, and the HR value; and

storing the calculated AV interval as an operating AV interval in a memory structure of a pacing therapy delivery device.

2. A method according to claim 1, further comprising:

operating the delivery device in a bi-ventricular pacing mode based at least in part upon the optimized AV interval.

3. A method according to claim 1, further comprising:

solving a set coefficients for said linear relationship after determining an AVopt interval using a conventional echocardiographic imaging study.

4. A method according to claim 1, wherein the step of measuring the temporal cardiac parameters comprises:

deploying a temporary pacing and sensing lead into electrical communication with the heart.

5. A method according to claim 1, wherein the step of measuring the temporal cardiac parameters comprises:

deploying a chronic pacing and sensing lead into communication with the heart.

6. A method according to claim 1, wherein the step of measuring the temporal cardiac parameters comprises:

deploying a subcutaneous cardiac sensing array into a position spaced from, but in electrical communication with, the heart.

7. A method according to claim 1, wherein the step of measuring the temporal cardiac parameters comprises:

deploying at least one surface sensing electrode into communication with the heart.

8. A method according to claim 1, wherein the step of measuring the temporal cardiac parameters comprises one of:

deploying a temporary pacing lead into communication with the heart.

9. A method according to claim 1, further comprising

storing at least one of the following values in a memory structure:

the sensed PWd value, the sensed PR interval value, the sensed or paced QRSd value, the HR value.

10. A method according to claim 1, wherein the parameters are measured via a vector between a defibrillation electrode and a portion of the housing of the device.

11. A method according to claim 1, further comprising:

measuring at least one of PR and HR more frequently than at least one of PWd and QRSd; and

calculating AVopt based upon the measured values.

12. A method according to claim 1, further comprising:

calculating a sensed-AV (SAV) interval based upon the AVopt value.

13. A method according to claim 12, further comprising:

measuring a current HR value, and wherein the calculated SAV interval is decremented in the event that the current HR value is increasing.

14. A method according to claim 13, wherein the SAV interval is decremented between about 0.25 milliseconds (ms) and about 3 ms for each additional beat per minute (bpm) the HR value increases.

15. A method according to claim 1, further comprising:

calculating a paced-AV (PAV) interval based upon the AVopt value.

16. A method according to claim 15, further comprising:

measuring a current HR value, and wherein the calculated SAV interval is decremented in the event that the current HR value is increasing.

17. A method according to claim 16, wherein the SAV interval is decremented between about 0.25 milliseconds (ms) and about 3 ms for each additional beat per minute (bpm) the HR value increases.

18. An apparatus for adjusting an operating atrio-ventricular (AV) interval in a cardiac pacing therapy delivery device, comprising:

means for measuring the following temporal cardiac parameters of a subject'"'"'s heart;

a P-wave duration (PWd) value, a sensed intrinsic atrioventrical (PR) interval, a sensed or paced QRS duration (QRSd) value, a heart rate (HR) for at least one cardiac cycle;

means for calculating an optimized AV interval (AVopt) as a linear function of the sensed PWd value, the sensed PR interval value, the sensed or paced QRSd value, and the HR value; and

means for storing the calculated AV interval as an operating AV interval in a memory structure of a pacing therapy delivery device for diverse values of the measured parameters.

19. An apparatus according to claim 18, further comprising:

means for operating the device in a bi-ventricular pacing mode based at least in part upon the optimized AV interval.

20. A computer medium for storing executable instructions operable under computer processor control to adjust an operating atrio-ventricular (AV) interval in a cardiac pacing therapy delivery device, comprising:

instructions;

instructions for measuring the following temporal cardiac parameters of a subject'"'"'s heart;

a P-wave duration (PWd) value, a sensed intrinsic atrioventrical (PR) interval, a sensed or paced QRS duration (QRSd) value, a heart rate (HR) for at least one cardiac cycle;

instructions for calculating an optimized AV interval (AVopt) as a linear function of the sensed PWd value, the sensed PR interval value, the sensed or paced QRSd value, and the HR value; and

instructions for storing the calculated AV interval as an operating AV interval in a memory structure of a pacing therapy delivery device.

21. A computer readable medium according to claim 20, further comprising:

instructions for operating the device in a bi-ventricular pacing mode based at least in part upon the optimized AV interval.

22. An apparatus for adjusting an operating atrio-ventricular (AV) interval in a pacing therapy delivery device, comprising:

at least a pair of electrodes adapted to sense a PQRST complex, including a P-wave, a sensed intrinsic atrioventrical event (PR), a QRS complex, a heart rate (HR, based on successive R-waves);

a processor coupled to the at least a pair of electrodes and adapted to determine a P-wave duration (PWd) value beginning from a sensed atrial event, an intrinsic atrioventrical (PR) interval based upon, a sensed or paced QRS duration (QRSd) value, and a heart rate (HR) for at least one cardiac cycle;

means for calculating an optimized AV interval (AVopt) as a linear function of the sensed PWd value, the sensed PR interval value, the sensed or paced QRSd value, and the HR value; and

a memory structure adapted to receive the AVopt from the means for calculating as an operating AV interval in a pacing therapy delivery device for diverse values of the measured parameters.