LIQUID SAMPLE MEASUREMENT METHOD AND APPARATUS

• US 20090236237A1
• Filed: 07/04/2007
• Published: 09/24/2009
• Est. Priority Date: 07/05/2006
• Status: Active Grant

• Current Assignee: PHC Holdings Corporation
• Original Assignee: Panasonic Corporation (Panasonic Holdings Corporation)
• Inventors: Shinno, Teppei, Takahara, Yoshifumi
• Granted Patent: US 8,287,718 B2
• Time in Patent Office: Days
• US Class Current: 205/792
• CPC Class Codes: C12Q 1/54 involving glucose or galactose
• CPC Class Codes: G01N 27/3274 Corrective measures, e.g. error detection, compensation for temperature or hematocrit, calibration coding of calibration information G01N33/48771
• CPC Class Codes: G01N 33/5438 Electrodes
• CPC Class Codes: G01N 33/54393 Improving reaction conditions or stability, e.g. by coating or irradiation of surface, by reduction of non-specific binding, by promotion of specific binding

Abstract

A liquid sample measurement apparatus of the present invention is provided with a timer (122) for measuring the time from when a biosensor (30) is attached to a liquid sample measurement device (110a) which measures the concentration of a specific component in a liquid sample that is applied to the biosensor (30) to when the liquid sample is applied to the biosensor (30), and correction based on the time measured by the timer (122) is performed to the measurement result of the concentration of the specific component in the liquid sample that is applied to the biosensor (30). Thereby, the measurement precision can be enhanced with utilizing the correction algorithm in which the ambient temperature and the temperature of the biosensor itself are considered.

Claims

1. A liquid sample measurement method of attaching a biosensor to a measurement device and measuring the concentration of a specific component in a liquid sample that is applied to the biosensor, including the steps of:

measuring the time from when the biosensor is attached to the measurement device to when the liquid sample is applied to the sensor, and

performing correction for the measurement result of the concentration of the specific component in the liquid sample that is applied to the biosensor, on the basis of the measured time.

4. A liquid sample measurement method as defined in claim 1, wherein

the amount of correction for the measurement result of the concentration of the specific component in the liquid sample that is applied to the biosensor is varied according to the measured time from when the biosensor is attached to the measurement device to when the liquid sample is applied to the sensor.

5. A liquid sample measurement method as defined in claim 4, wherein

the amount of correction is reduced when the measured time from when the biosensor is attached to the measurement device to when the liquid sample is applied to the sensor is long.

6. A liquid sample measurement method as defined in claim 1, wherein

whether correction should be performed or not for the measurement result of the concentration of the specific component in the liquid sample that is applied to the biosensor is judged according to the measured time from when the biosensor is attached to the measurement device to when the liquid sample is applied to the sensor.

7. A liquid sample measurement method as defined in claim 6, wherein

said correction is performed when the measured time from when the biosensor is attached to the measurement device to when the liquid sample is applied to the sensor is within a specific time period.

8. A liquid sample measurement method as defined in claim 1, wherein

the amount of correction for the measurement result is determined according to the measurement result of the concentration of the specific component in the liquid sample that is applied to the biosensor.

9. A liquid sample measurement method as defined in claim 1, wherein

the amount of correction for the measurement result of the concentration of the specific component in the liquid sample that is applied to the biosensor is determined according to the ambient temperature at the measurement.

10. A liquid sample measurement method as defined in claim 1, wherein

the amount of correction for the measurement result of the concentration of the specific component in the liquid sample that is applied to the biosensor is determined according to a second specific component which exists in the liquid sample and is other than said specific component.

11. A liquid sample measurement method as defined in claim 10, wherein

the liquid sample is blood, and

the amount of correction is determined according to the hematocrit value of the blood.

13. A liquid sample measurement method as defined in claim 1, wherein

the amount of correction for the measurement result is determined according to the kind of the liquid sample that is applied to the biosensor.

2. A liquid sample measurement method of attaching a biosensor to a measurement device and measuring the concentrations of plural specific components in a liquid sample that is applied to the biosensor, including the steps of:

measuring the time from when the biosensor is attached to the measurement device to when the liquid sample is applied to the sensor, and

performing corrections for the respective measurement results of the concentrations of the plural specific components in the liquid sample that is applied to the biosensor, on the basis of the measured time.

25. A liquid sample measurement method as defined in claim 2, wherein

the amount of correction for the measurement result of the concentration of the specific component in the liquid sample that is applied to the biosensor is varied according to the measured time from when the biosensor is attached to the measurement device to when the liquid sample is applied to the sensor.

27. A liquid sample measurement method as defined in claim 2, wherein

whether correction should be performed or not for the measurement result of the concentration of the specific component in the liquid sample that is applied to the biosensor is judged according to the measured time from when the biosensor is attached to the measurement device to when the liquid sample is applied to the sensor.

29. A liquid sample measurement method as defined in claim 2, wherein

the amount of correction for the measurement result is determined according to the measurement result of the concentration of the specific component in the liquid sample that is applied to the biosensor.

31. A liquid sample measurement method as defined in claim 2, wherein

the amount of correction for the measurement result of the concentration of the specific component in the liquid sample that is applied to the biosensor is determined according to the ambient temperature at the measurement.

33. A liquid sample measurement method as defined in claim 2, wherein

the amount of correction for the measurement result of the concentration of the specific component in the liquid sample that is applied to the biosensor is determined according to a second specific component which exists in the liquid sample and is other than said specific component.

35. A liquid sample measurement method as defined in claim 2, wherein

the amount of correction for the measurement result is determined according to the kind of the liquid sample that is applied to the biosensor.

3. A liquid sample measurement method of attaching plural biosensors of different types to a measurement device and measuring the concentrations of specific components in liquid samples that are applied to the respective biosensors, including the steps of:

measuring the time from when each of the biosensors is attached to the measurement device to when the liquid sample is applied to the sensor, and

performing correction for the measurement result of the concentration of the specific component in the liquid sample that is applied to the biosensor, on the basis of the measured time and the type of the biosensor.

26. A liquid sample measurement method as defined in claim 3, wherein

the amount of correction for the measurement result of the concentration of the specific component in the liquid sample that is applied to the biosensor is varied according to the measured time from when the biosensor is attached to the measurement device to when the liquid sample is applied to the sensor.

28. A liquid sample measurement method as defined in claim 3, wherein

whether correction should be performed or not for the measurement result of the concentration of the specific component in the liquid sample that is applied to the biosensor is judged according to the measured time from when the biosensor is attached to the measurement device to when the liquid sample is applied to the sensor.

30. A liquid sample measurement method as defined in claim 3, wherein

the amount of correction for the measurement result is determined according to the measurement result of the concentration of the specific component in the liquid sample that is applied to the biosensor.

32. A liquid sample measurement method as defined in claim 3, wherein

the amount of correction for the measurement result of the concentration of the specific component in the liquid sample that is applied to the biosensor is determined according to the ambient temperature at the measurement.

34. A liquid sample measurement method as defined in claim 3, wherein

the amount of correction for the measurement result of the concentration of the specific component in the liquid sample that is applied to the biosensor is determined according to a second specific component which exists in the liquid sample and is other than said specific component.

36. A liquid sample measurement method as defined in claim 3, wherein

the amount of correction for the measurement result is determined according to the kind of the liquid sample that is applied to the biosensor.

12. A liquid sample measurement method of attaching a biosensor to a measurement device and measuring the concentration of a specific component of a liquid sample that is applied to the sensor, including the steps of:

measuring the time from when the biosensor is attached to the measurement device to when the liquid sample is applied to the sensor, and the ambient temperature at the measurement,

correcting the measured ambient temperature on the basis of the measured time from when the biosensor is attached to the measurement device to when the liquid sample is applied to the sensor, and

correcting the measurement result of the concentration of the specific component in the liquid sample that is applied to the biosensor, on the basis of the corrected ambient temperature.

14. A liquid sample measurement apparatus having a biosensor attached thereto, which measures the concentration of a specific component in a liquid sample that is applied to the biosensor, including:

a time measurement means for measuring the time from when the biosensor is attached to when the liquid sample is applied to the sensor; and

a measurement result correction means for correcting the measurement result of the concentration of the specific component in the liquid sample that is applied to the biosensor, on the basis of the time measured by the time measurement means.

15. A liquid sample measurement apparatus as defined in claim 14, wherein

said measurement result correction means changes the amount of correction for the measurement result of the concentration of the specific component in the liquid sample that is applied to the biosensor, according to the time measured by the time measurement means.

16. A liquid sample measurement apparatus as defined in claim 15, wherein

said measurement result correction means reduces the amount of correction when the time measured by the time measurement means is long.

17. A liquid sample measurement apparatus as defined in claim 14, wherein

said measurement result correction means judges whether correction should be performed or not for the measurement result of the concentration of the specific component in the liquid sample that is applied to the biosensor, according to the time measured by the time measurement means.

18. A liquid sample measurement apparatus as defined in claim 17, wherein

said measurement result correction means performs said correction when the time measured by the time measurement means is within a specific time.

19. A liquid sample measurement apparatus as defined in claim 14, wherein

said measurement result correction means determines the amount of correction for the measurement result according to the measurement result of the concentration of the specific component in the liquid sample that is applied to the biosensor.

20. A liquid sample measurement apparatus as defined in claim 14 further including

a temperature measurement part for measuring the ambient temperature at the measurement, and

said measurement result correction means determining the amount of correction for the measurement result of the concentration of the specific component in the liquid sample that is applied to the biosensor, according to the ambient temperature measured by the temperature measurement part.

21. A liquid sample measurement apparatus as defined in claim 14, wherein

said measurement result correction means determines the amount of correction for the measurement result of the concentration of the specific component in the liquid sample that is applied to the biosensor, according to a second specific component which exists in the liquid sample and is other than said specific component.

22. A liquid sample measurement apparatus as defined in claim 21, wherein

said liquid sample is blood, and

said second specific component is the hematocrit value of the blood.

23. A liquid sample measurement apparatus as defined in claim 14, wherein

said measurement result correction means determines the amount of correction for the measurement result according to the type of the liquid sample that is applied to the biosensor.

24. A liquid sample measurement apparatus having a biosensor attached thereto, which measures the concentration of a specific component in a liquid sample that is applied to the biosensor, including:

a time measurement means for measuring the time from when the biosensor is attached to when the liquid sample is applied to the sensor;

a temperature sensor for measuring the ambient temperature at measurement;

a temperature correction means for correcting the ambient temperature measured by the temperature sensor, on the basis of the time measured by the time measurement means; and

a measurement result correction means for performing correction for the measurement result of the concentration of the specific component in the liquid sample that is applied to the biosensor, on the basis of the corrected ambient temperature.