Verifiable hand cleansing formulation and method

• US 20090237651A1
• Filed: 10/30/2007
• Published: 09/24/2009
• Est. Priority Date: 11/01/2006
• Status: Abandoned Application

• Current Assignee: Infection Prevention Systems Incorporated
• Original Assignee: Infection Prevention Systems Incorporated
• Inventors: Arndt, Douglas C, Hwang, Franklin D.
• Application Number:
  US12/311,089
• Publication Number:
  US 20090237651A1
• Time in Patent Office: Days
• US Class Current: 356/229
• CPC Class Codes: A01N 25/00 Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application , e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
• CPC Class Codes: A61K 49/0006 Skin tests, e.g. intradermal testing, test strips, delayed hypersensitivity
• CPC Class Codes: A61K 49/006 Biological staining of tissues in vivo, e.g. methylene blue or toluidine blue O administered in the buccal area to detect epithelial cancer cells, dyes used for delineating tissues during surgery
• CPC Class Codes: A61K 49/0063 characterised by a special physical or galenical form, e.g. emulsions, microspheres

Abstract

A hand cleansing formulation in the form of a soap/disinfectant (liquid, foam, cream or powder) in solution contains a marker agent (e.g., fluorescent or phosphorescent agent(s)) aggregated with a non-marker binder material. By vigorously scrubbing the hands together, as required by a proper hand washing procedure, the aggregates are dissociated to allow the measurement of the fluorescence/phosphorescence intensity under an activation light source, i.e., UV, IR. This intensity measurement directly relates to the thoroughness of the hand scrubbing steps, thereby allowing the thoroughness of hand scrubbing during a hand washing event to be judged and monitored.

Claims

1. A hand cleansing and use evaluation permitting formulation comprising:

a) a cleansing compound capable of cleansing a user'"'"'s hand by removing, destroying, neutralizing or inhibiting the growth of pathogenic microorganisms through a hand scrubbing action with or without the presence of water; and

b) a marker agent visibly detectable when exposed to light having a wavelength in the visible or non-visible spectrum, the marker being aggregated with a non-marker binder, the binder being capable of releasing the marker when the cleansing formulation is subject to the scrubbing action, the detectability of the marker being noticeably increased when released from the binder as compared to its detectability when aggregated with the binder.

2. The cleansing formulation of claim 1 wherein the dimension of the aggregates is within the range of about five to several hundred microns.

3. The cleansing formulation of claim 1 wherein the agglomerates are bound together mechanically and/or electrostatically in a solution.

4. The cleansing formulation of claim 1 wherein the marker agent is selected from one or more of the groups consisting of fluorophors or phosphors.

5. The cleansing formulation of claim 4 wherein the fluorescent and/or phosphorescent agent(s) are substantially water-insoluble.

6. The cleansing formulation of claim 5 wherein the binder is substantially water-insoluble.

7. The cleansing formulation of claim 6 wherein water-insoluble binder(s) are hydrated and softened within the solution facilitating disintegration of the aggregate during hand scrubbing steps.

8. The cleansing formulation of claim 1 wherein the binder is selected from one or more of the following:

lactose, microcrystalline cellulose, hydroxypropylmethylcellulose, polyvinyl alcohol, mannitol, alkylated celluloses, polyvinylpyrollidone (PVP), copolymers of PVP using other resins, and alkylated PVPs.

9. The cleansing formulation of claim 4 wherein the fluorescent and/or phosphorescent agent(s) are in a pigment form substantially preventing the staining of the human skin.

10. The cleansing formulation of claim 9 wherein the marker further contains one or more anti-Stoke'"'"'s pigments.

11. The cleansing formulation of claim 9 wherein the pigment is a mineral.

12. The cleansing formulation of claim 11 wherein the mineral is selected from one or more of the group consisting of Zinc sulfides doped with copper, strontium, manganese;

calcium sulfides, alkaline earth aluminates, alkaline earth silicates, basic metallo-phosphates, alkaline earth oxides, alkaline earth sulfides, alkaline earth carbonates, alkaline earth borates, alkaline earth tungstates, alkaline earth molybdates with many metal dopants to constitute the mineral as phosphors;

also inorganic oxysulphides like UC-3 red, UC-8 green and UC-60 blue from Artemis Company.

13. The formulation as described in claim 12 wherein the pigment is a noble or rare earth metal in the colloidal state or as nanoparticles.

14. The formulation as described in claim 4 where the marker is a water-insoluble fluorescent agent in the form of a polymer or plastic, selected from the class of organic dyes dissolved in organic polymeric resins including AIT-4466 Invisible Yellow, D034 Yellow, IPO-13 red, IPO-15 orange, IPO-18 green and IPO-19 blue;

PF-00 invisible blue, PF-01 invisible orange, PF-RT invisible red, PF-07 invisible blue-white, PF-08 invisible bright white, PF-09 invisible violet from Risk Reactor;

PSP, MDP and MTC series of dyes from Spectra System Corp.

15. The formulation as described in claim 4 wherein the marker is a phosphorescent non-skin staining dye.

16. The formulation as described in claim 15 wherein the marker is an organic molecule having at least one carbon ring functional as a dye intermediate.

17. The formulation as described in claim 16 wherein the organic molecule has between two and six carbon rings, which functions as a dye intermediate.

18. The formulation as described in claim 4 wherein the marker is selected from the group consisting of coumarinic compounds, stilbene and its derivatives, pyrene and its derivatives, anthracenes, tetracenes, pentracenes, quinolines, quinones, aryl methanes, naphthacenes, fluoresceins, anilines, thiazoles, oxazoles, pyranines, carbazoles, rhodamines, dansylated compounds, propidiums, biotin derivatives, ethidiums, cyanines, uranines, benzoxazoles, benzothizaoles, succimidyl compounds dialdehydes, quinoids.

19. The formulation of claim 1 wherein the detectability of the marker is substantially increased when released from the binder.

21. A method of verifying that a hand washing protocol meets a preset standard of hand hygiene comprising:

a) dispensing a quantity of the cleansing formulation of claims 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19 or 20 onto a person'"'"'s hands;

b) subsequently obtaining a quantitative measurement of the light emitted from the person'"'"'s hands following a scrubbing action between the hands with the formulation thereon;

c) determining whether or not the measured quantity exceeds a preset amount indicative that the standard has been met.

22. The method of claim 21 including the step of advising the person to scrub his/her hands together after the formulation has been dispensed before the measurement is made.

23. The method of claim 22 further including the step of advising the person that he/she must repeat the scrubbing step in the event that measured quantity of light is below the preset amount.

20. A hand cleansing and use verification formulation comprising:

a) a cleansing compound capable of removing, destroying, neutralizing or inhibiting the growth of pathogenic microorganisms on a person'"'"'s hands through a hand scrubbing action; and

b) a fluorescent/phosphorescent marker agent aggregated with a non-fluorescent/phosphorescent binder, the aggregates being arranged to be broken up releasing the marker when subjected to vigorous scrubbing action between a user'"'"'s hands bearing the formulation, the marker having the characteristics of substantially increasing its visible detectability when released from the binder and subjected to stimulating radiations.