Pressure-Reinforced Fluidic Chip

• US 20090238722A1
• Filed: 03/18/2008
• Published: 09/24/2009
• Est. Priority Date: 03/18/2008
• Status: Abandoned Application

• Current Assignee: Agilent Technologies, Inc.
• Original Assignee: Agilent Technologies, Inc.
• Inventors: Mora-Fillat, Jose-Angel, Kraiczek, Karsten
• Application Number:
  US12/050,265
• Publication Number:
  US 20090238722A1
• Time in Patent Office: Days
• US Class Current: 422/68.100
• CPC Class Codes: B01L 2200/025 Align devices or objects to ensure defined positions relative to each other
• CPC Class Codes: B01L 2200/085 Protection against injuring the user
• CPC Class Codes: B01L 2300/0887 Laminated structure
• CPC Class Codes: B01L 2300/14 Means for pressure control
• CPC Class Codes: B01L 2300/18 Means for temperature control
• CPC Class Codes: B01L 2400/0415 electrical forces, e.g. electrokinetic
• CPC Class Codes: B01L 2400/0487 fluid pressure, pneumatics
• CPC Class Codes: B01L 3/502707 characterised by the manufacture of the container or its components by shaping or joining plastic parts B29C59/00, B29C65/00; by laminating B32B37/00; manufacture of microstructural devices in general B81C
• CPC Class Codes: B01L 3/502753 characterised by bulk separation arrangements on lab-on-a-chip devices, e.g. for filtration or centrifugation separation in general B01D; microapparatus for analysis using electrophoresis G01N27/44791; sample preparation G01N1/28
• CPC Class Codes: G01N 30/6095 Micromachined or nanomachined, e.g. micro- or nanosize

Abstract

A fluidic chip device adapted for processing a fluidic sample, the fluidic chip device comprising a substrate comprising a fluidic conduit for conducting the fluidic sample under pressure, and two reinforcing structures between which the substrate is arranged, wherein the two reinforcing structures are connected to one another to reinforce pressure resistance of the substrate.

Claims

1. A fluidic chip device adapted for processing a fluidic sample, the fluidic chip device comprising

a substrate comprising a fluidic conduit for conducting the fluidic sample under pressure;

two reinforcing structures between which the substrate is arranged, wherein the two reinforcing structures are connected to one another to reinforce pressure resistance of the substrate.

2. The fluidic chip device according to claim 1,

wherein the two reinforcing structures are plates.

3. The fluidic chip device according to claim 1,

wherein a shape and a surface area of the two reinforcing structures match to a shape and to a surface area of the substrate.

4. The fluidic chip device according to claim 1,

wherein the two reinforcing structures have a thickness being larger than a thickness of the substrate.

5. The fluidic chip device according to claim 1,

wherein the two reinforcing structures have a mechanical resistance being larger than a mechanical resistance of the substrate.

6. The fluidic chip device according to claim 1, comprising at least one of the following features:

the two reinforcing structures are connected to one another to reinforce the substrate by a non-positive locking mechanism;

the two reinforcing structures are connected to one another to reinforce the substrate by a positive locking mechanism;

the two reinforcing structures are connected to one another to reinforce the substrate by a material connection;

the two reinforcing structures are connected to one another to reinforce the substrate by traction anchoring;

the two reinforcing structures are arranged to encompass the substrate;

the two reinforcing structures are connected to one another to reinforce the substrate by at least one connection mechanism of the group consisting of a screwing connection, a clamping connection, and adhering connection, a magnetic connection, and a riveting connection.

7. The fluidic chip device according to claim 1,

wherein at least one of the two reinforcing structures comprises a fluidic sample drain opening adapted to drain a fluidic sample discharging from the fluidic conduit.

8. The fluidic chip device according to claim 1,

wherein at least one of the two reinforcing structures comprises an attachment piece adapted for inserting a separation substance in the fluidic conduit under pressure.

9. The fluidic chip device according to claim 1, comprising at least one of the following features:

at least one of the two reinforcing structures has a thickness in a range between 1 mm and 30 mm, particularly in a range between 2 mm and 10 mm, more particularly in a range between 4 mm and 6 mm;

the substrate has a thickness in a range between 25 μ

m and 300 μ

m, particularly in a range between 50 μ

m and 200 μ

m, more particularly in a range between 70 μ

m and 150 μ

m.

10. The fluidic chip device according to claim 1,

wherein the two reinforcing structures comprise at least one of a metal and a hard plastic.

11. The fluidic chip device according to claim 1,

wherein the two reinforcing structures are formed by injection molding.

12. The fluidic chip device according to claim 1,

wherein the substrate is a multi-layer substrate.

13. The fluidic chip device according to claim 1,

wherein the substrate comprises at least one through hole through which at least one connection element is guided which connects the two reinforcing structures to one another.

14. The fluidic chip device according to claim 1,

comprising a processing element provided in the fluidic conduit and adapted for interacting with the fluidic sample.

15. The fluidic chip device according to claim 14, comprising at least one of the following features:

the processing element is adapted for retaining the fluidic sample being a part a mobile phase and for allowing other components of the mobile phase to pass the processing element;

the processing element comprises a separation column;

the processing element comprises a chromatographic column for separating components of the fluidic sample;

the fluidic chip device is adapted to conduct a liquid sample through the processing element;

the fluidic chip device is adapted to conduct the fluidic sample through the processing element with a high pressure;

the fluidic chip device is adapted to conduct the fluidic sample through the processing element with a pressure of at least 100 bar, particularly of at least 500 bar, more particularly of at least 1000 bar;

at least a part of the processing element is filled with a fluid separating material;

at least a part of the processing element is filled with a fluid separating material, wherein the fluid separating material comprises beads having a size in the range of 1 μ

m to 50 μ

m;

at least a part of the processing element is filled with a fluid separating material, wherein the fluid separating material comprises beads having pores having a size in the range of 0.02 μ

m to 0.03 μ

m.

16. The fluidic chip device according to claim 1, comprising at least one of the following features:

the substrate comprises a plurality of layers which are connected to one another by lamination;

the substrate comprises a top layer, a bottom layer, and at least one intermediate layer sandwiched between the top layer and the bottom layer;

the substrate comprises a top layer, a bottom layer, and at least one intermediate layer sandwiched between the top layer and the bottom layer, wherein at least one of the at least one intermediate layer comprises the fluidic conduit through which the fluidic sample is to be conducted;

the substrate comprises a top layer, a bottom layer, and at least one intermediate layer sandwiched between the top layer and the bottom layer, wherein at least one of the at least one intermediate layer comprises an electrode structure to which an electric voltage is to be applied;

the substrate comprises at least one material of the group consisting of a plastic, a polymer, a metal, a semiconductor, and a ceramic;

the substrate has an essentially rectangular cross section;

the substrate has a plate shape;

the fluidic chip device is adapted as a fluid separation system for separating compounds of the fluidic sample;

the fluidic chip device is adapted as a fluid purification system for purifying the fluidic sample;

the fluidic chip device is adapted to analyze at least one physical, chemical and/or biological parameter of at least one compound of the fluidic sample;

the fluidic chip device comprises at least one of the group consisting of a sensor device, a test device for testing a device under test or a substance, a device for chemical, biological and/or pharmaceutical analysis, a capillary electrophoresis device, a liquid chromatography device, an HPLC device, a gas chromatography device, a gel electrophoresis device, an electronic measurement device, and a mass spectroscopy device;

the fluidic chip device is adapted as a microfluidic chip device;

the fluidic chip device is adapted as a nanofluidic chip device.

17. A method of fabricating a fluidic chip device for processing a fluidic sample, the method comprising

forming a fluidic conduit in a substrate through which fluidic conduit the fluidic sample is to be conducted under pressure;

arranging the substrate between two reinforcing structures;

connecting the two reinforcing structures to one another to reinforce pressure resistance of the substrate.

18. The method according to claim 17, further comprising

inserting a separation substance in the fluidic conduit under pressure;

removing the two reinforcing structures after the inserting and before conducting the fluidic sample through the fluidic conduit.

19. The method according to claim 17, further comprising

maintaining the two reinforcing structures enclosing the substrate while conducting the fluidic sample through the fluidic conduit under pressure.