Nondegradable Hydrogels For Medical Device Application
First Claim
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1. A polymeric material formed from macromers of a general formula 1:
- wherein W, W′
are each independently O or CH2, n is between about 1 and about 500, macromers of a general formula 2;
wherein W, W′ and
W″
are each independently O or CH2, x, y, and z are each independently between about 1 and about 500, or combinations thereof, and wherein at least two macromers are cross-linked thereby forming a hydrogel.
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Abstract
Disclosed are nondegradable hydrogels used to coat or form at least a portion of a medical device. The hydrogels may be formed from functionalized PEG based macromers. These hydrogels are easy to sterilize, transport and store. Methods of forming these hydrogels as described herein are included.
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Citations
18 Claims
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1. A polymeric material formed from macromers of a general formula 1:
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wherein W, W′
are each independently O or CH2, n is between about 1 and about 500, macromers of a general formula 2;wherein W, W′ and
W″
are each independently O or CH2, x, y, and z are each independently between about 1 and about 500, or combinations thereof, and wherein at least two macromers are cross-linked thereby forming a hydrogel.- View Dependent Claims (2, 3, 4, 5, 6)
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7. An implantable medical device comprising a polymeric material, said polymeric material formed from macromers of a general formula 1:
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wherein n is between about 1 and about 500, macromers of a general formula 2; wherein x, y, and z are each independently between about 1 and about 500, or combinations thereof, and wherein at least two macromers are cross-linked thereby forming a hydrogel. - View Dependent Claims (8, 9, 10, 11, 12, 13, 14)
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15. A method of forming a hydrogel comprising the steps of:
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a) choosing at least one macromer selected from the group consisting of Formula 1 wherein n is between about 1 and about 500, Formula 2 wherein x, y, and z are each independently between about 1 and about 500, or a combination thereof; b) choosing appropriate concentrations of said macromer(s); c) selecting an appropriate initiator; and d) reacting said macromers and said initiator, thereby forming a hydrogel. - View Dependent Claims (16, 17, 18)
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Specification