MONOCLONAL ANTIBODIES AND USES THEREOF
First Claim
Patent Images
1. An isolated antibody that binds with greater specificity to an amyloid beta (Aβ
- ) protein globulomer than to an amyloid beta protein monomer.
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0 Petitions
Accused Products
Abstract
The subject invention relates to monoclonal antibodies (e.g., 8F5 and 8C5) that may be used, for example, in the prevention, treatment and diagnosis of Alzheimer'"'"'s Disease or other neurodegenerative disorders.
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Citations
56 Claims
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1. An isolated antibody that binds with greater specificity to an amyloid beta (Aβ
- ) protein globulomer than to an amyloid beta protein monomer.
- View Dependent Claims (2, 3, 4, 5, 6, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56)
- 7. A hybridoma having American Type Culture Collection designation number PTA-7238.
- 9. A monoclonal antibody comprising a variable heavy chain encoded by SEQ ID NO:
- 11. A monoclonal antibody comprising a variable light chain encoded by SEQ ID NO:
- 15. A monoclonal antibody comprising SEQ ID NO:
- 17. A monoclonal antibody comprising SEQ ID NO:
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21. An isolated antibody that binds with greater specificity to an amyloid beta protein globulomer than to an amyloid beta protein fibril.
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22. The isolated antibody of claim 22 wherein said antibody is monoclonal.
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23. The isolated antibody of claim 23 wherein said monoclonal antibody is produced by a hybridoma having American Type Culture Collection designation number PTA-7238 or PTA-7407.
- 24. A hybridoma having American Type Culture Collection designation number PTA-7407.
- 26. A monoclonal antibody comprising a variable heavy chain encoded by SEQ ID NO:
- 28. A monoclonal antibody comprising a variable light chain encoded by SEQ ID NO:
- 32. A monoclonal antibody comprising SEQ ID NO:
- 34. A monoclonal antibody comprising SEQ ID NO:
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36. A monoclonal antibody comprising a variable heavy chain, wherein said variable heavy chain comprises at least one complementarity determining region (CDR) selected from the group consisting of SEQ ID NO:
- 13, SEQ ID NO;
14 and SEQ ID NO;
15.
- 13, SEQ ID NO;
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37. A monoclonal antibody comprising a variable light chain, wherein said variable light chain comprises at least one CDR selected from the group consisting of SEQ ID NO:
- 16, SEQ ID NO;
17 and SEQ ID NO;
18. - View Dependent Claims (38)
- 16, SEQ ID NO;
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39. A monoclonal antibody comprising a variable heavy chain, wherein said variable heavy chain comprises at least one complementarity determining region (CDR) selected from the group consisting of SEQ ID NO:
- 5, SEQ ID NO;
6 and SEQ ID NO;
7.
- 5, SEQ ID NO;
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40. A monoclonal antibody comprising a variable light chain, wherein said variable light chain comprises at least one CDR selected from the group consisting of SEQ ID NO:
- 6, SEQ ID NO;
9 and SEQ ID NO;
10. - View Dependent Claims (41)
- 6, SEQ ID NO;
Specification