×

METHOD AND APPARATUS FOR DETERMINING COPY NUMBER VARIATION USING DIGITAL PCR

  • US 20090239308A1
  • Filed: 07/09/2008
  • Published: 09/24/2009
  • Est. Priority Date: 03/19/2008
  • Status: Active Grant
First Claim
Patent Images

1. A method of estimating a concentration of DNA molecules in a biological sample, the method comprising:

  • storing a number of a plurality of reaction sites in a memory;

    distributing the biological sample among the plurality of reaction sites;

    determining a number of the plurality of reaction sites characterized by a presence of one or more of the DNA molecules;

    computing a portion of the plurality of reaction sites characterized by the presence of the one or more of the DNA molecules;

    estimating the concentration of the DNA molecules as a function of the portion of the plurality of reaction sites; and

    computing a confidence interval for the estimated concentration of DNA molecules.

View all claims
  • 2 Assignments
Timeline View
Assignment View
    ×
    ×