Biocidal compositions

• US 20090239749A1
• Filed: 06/29/2007
• Published: 09/24/2009
• Est. Priority Date: 07/13/2006
• Status: Abandoned Application

• Current Assignee: IOTA NanoSolutions Limited
• Original Assignee: IOTA NanoSolutions Limited
• Inventors: Wang, Dong, Rannard, Steven Paul, Foster, Alison Jayne, Duncalf, David John, Long, James
• Application Number:
  US12/309,293
• Publication Number:
  US 20090239749A1
• Time in Patent Office: Days
• US Class Current: 504/116.100
• CPC Class Codes: A01N 25/04 Dispersions, emulsions, suspoemulsions, suspension concentrates or gels foams A01N25/16
• CPC Class Codes: A01N 31/16 with two or more oxygen or sulfur atoms directly attached to the same aromatic ring system
• CPC Class Codes: A01N 37/18 containing the group —CO—N<, e.g. carboxylic acid amides or imides; Thio analogues thereof
• CPC Class Codes: A01N 43/54 1,3-Diazines; Hydrogenated 1,3-diazines
• CPC Class Codes: A01N 53/00 Biocides, pest repellants or attractants, or plant growth regulators containing cyclopropane carboxylic acids or derivatives thereof
• CPC Class Codes: A61K 31/167 having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
• CPC Class Codes: A61K 9/10 Dispersions; Emulsions A61K9/06 takes precedence; composition of dispersions, emulsions A61K47/00
• CPC Class Codes: A61K 9/1617 Organic compounds, e.g. phospholipids, fats
• CPC Class Codes: A61K 9/1635 obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
• CPC Class Codes: A61K 9/1641 obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
• CPC Class Codes: A61K 9/1652 Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin homeopathic globules A61K9/1623
• CPC Class Codes: A61K 9/19 lyophilised , i.e. freeze-dried, solutions or dispersions lyophilised products with subsequent particle size reduction A61K9/14; granules or pellets made by lyphilisation A61K9/1682; solid oral dosage forms made by lyophilisation A61K9/2095; lyophilisation additives A61K47/00
• CPC Class Codes: A61P 1/00 Drugs for disorders of the alimentary tract or the digestive system
• CPC Class Codes: A61P 1/08 for nausea, cinetosis or vertigo; Antiemetics
• CPC Class Codes: A61P 1/10 Laxatives
• CPC Class Codes: A61P 1/12 Antidiarrhoeals
• CPC Class Codes: A61P 1/14 Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
• CPC Class Codes: A61P 25/00 Drugs for disorders of the nervous system
• CPC Class Codes: A61P 25/04 Centrally acting analgesics, e.g. opioids
• CPC Class Codes: A61P 25/06 Antimigraine agents
• CPC Class Codes: A61P 25/28 : for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
• CPC Class Codes: A61P 27/12 : for cataracts
• CPC Class Codes: A61P 29/00 : Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
• CPC Class Codes: A61P 31/00 : Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
• CPC Class Codes: A61P 31/10 : Antimycotics
• CPC Class Codes: A61P 33/00 : Antiparasitic agents
• CPC Class Codes: A61P 33/02 : Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
• CPC Class Codes: A61P 33/06 : Antimalarials
• CPC Class Codes: A61P 35/00 : Antineoplastic agents
• CPC Class Codes: A61P 43/00 : Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
• CPC Class Codes: A61P 9/00 : Drugs for disorders of the cardiovascular system
• CPC Class Codes: A61P 9/10 : for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
• CPC Class Codes: A61P 9/12 : Antihypertensives
• CPC Class Codes: Y02A 50/30 : Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

The invention provides a solvent-free biocidal composition of improved efficacy comprising at least one water insoluble biocide (preferably a herbicide) and a water-soluble carrier material, wherein the water-insoluble biocide is dispersed through the carrier material in nano-disperse form having a peak diameter of the nano-disperse form below 1000 nm. The invention also provides a process which comprises spray drying a solution of the biocide and a solution of a water-soluble carrier to obtain a solvent free dispersion of the biocide in the carrier, which, when dissolved in water, produces a nano-disperse biocide. The invention also provides an aqueous dispersion of a water insoluble biocide and a water-soluble carrier obtained by the dispersion of the composition of the solvent free composition in water.

Claims

1. A solvent-free biocidal composition of improved efficacy comprising at least one water insoluble biocide and a water-soluble carrier material, wherein the water-insoluble biocide is dispersed through the carrier material in nano-disperse form having a peak diameter of the nano-disperse form below 500 nm.

2. A composition according to claim 1 wherein the peak diameter of the water-insoluble biocide is below 100 nm.

3. A composition according to claim 1 wherein the water insoluble biocide has solubility in water at ambient temperature of less than 15 mg/L.

4. A composition according to claim 1 wherein the solvent free dispersion comprises at most 25% wt of biocide.

5. A composition according to claim 1 wherein the biocide is a herbicide.

6. An aqueous dispersion of a water insoluble biocide and a water-soluble carrier obtained by the dispersion of the composition of claim 1 in water.

7. A process for preparing a composition according to claim 1 which comprises spray drying a solution of the biocide and a solution of a water-soluble carrier to obtain a solvent free dispersion of the biocide in the carrier, which, when dissolved in water, produces a nano-disperse biocide.

8. A process for preparing a composition according to claim 1 which comprises the steps of:

a) providing an emulsion comprising;

i) a solution of the biocide agent in at least one water-immiscible solvent for the same, and

ii) an at least partially aqueous solution of the carrier, and,

b) drying the emulsion to remove water and the water-immiscible solvent to obtain a nano-dispersion of the biocide in the carrier

9. A process for preparing a composition according to claim 1 which comprises the steps of:

a) providing a mixture comprising;

i) at least one non-aqueous solvent,

ii) optionally, water,

iii) a water-soluble carrier material soluble in the mixture of (i) and (ii) and

iv) a water-insoluble biocide agent which is soluble in the mixture of (i) and (ii), and,

b) drying said mixture to remove the non-aqueous solvent and any water present to obtain a nano-dispersion of the biocide in the carrier.

10. A process for the preparation of a biocide composition for use in the prophylaxis or treatment of infections or infestations which comprises the step of preparing a composition according to claim 1.

11. A composition obtainable by the process of claim 1.

12. A process for the treatment of a substrate other than a medical treatment which comprises the step of contacting the substrate with a composition according to claim 1.

13. A process for the delivery of a water-insoluble biocide which comprises the steps of:

a) dissolving in water a nano-dispersion of a water-insoluble biocide in a water soluble carrier material, according to claim 1,

b) optionally, adding other components to the dispersion, and,

c) treating a substrate with the aqueous nano-dispersion of the biocide.

14. A process according to claim 13 wherein step (c) comprises spraying, dipping or washing the substrate.

15. A process according to claim 13 wherein the substrate is selected from a plant, soil, an animal, bedding for animals, fodder or an article manufactured from a plant or an animal.

16. A process comprising using a composition according to claim 1 for the treatment of an infestation.

17. A process according to claim 8 wherein the drying step comprises spray drying.