SELF-FOAMING CEMENT FOR VOID FILLING AND/OR DELIVERY SYSTEMS
First Claim
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1. A composition comprising a dry element and a wet element;
- wherein said dry element includes tricalcium phosphate, hydroxyapatite, strontium hydrophosphate and one or more members selected from the group consisting of strontium carbonate and sodium bicarbonate;
and wherein said wet element includes a phosphate buffer sufficient to keep the composition acidic when the dry element and the wet element are mixed together.
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Abstract
A self-foaming bone cement is described herein. In one variation, the bone cements include a self setting calcium phosphate cement formulation which when cured, forms macroscopic pores of varying sizes and densities with sufficient surface area to provide substantial regions for bone turnover.
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Citations
21 Claims
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1. A composition comprising a dry element and a wet element;
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wherein said dry element includes tricalcium phosphate, hydroxyapatite, strontium hydrophosphate and one or more members selected from the group consisting of strontium carbonate and sodium bicarbonate; and wherein said wet element includes a phosphate buffer sufficient to keep the composition acidic when the dry element and the wet element are mixed together. - View Dependent Claims (2, 3, 4, 5)
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6. A bone cement comprising:
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a dry element comprising tricalcium phosphate, hydroxyapatite, strontium hydrophosphate and one or more members selected from the group consisting of strontium carbonate and sodium bicarbonate; and a wet element comprising a phosphate buffer sufficient to keep the composition acidic when the dry element and the wet element are mixed together, wherein the calcium phosphate cement is configured for placement in a void inside a bone in a patient'"'"'s body, and wherein the calcium phosphate cement, when cured, forms macroscopic pores of varying sizes and densities with sufficient surface area to provide regions for bone remodeling. - View Dependent Claims (7, 8, 9, 10, 11, 12)
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13. A method of making a bone cement comprising:
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mixing together a dry element and a wet element; wherein said dry element includes tricalcium phosphate, hydroxyapatite, strontium hydrophosphate and one or more members selected from the group consisting of strontium carbonate and sodium bicarbonate; and wherein said wet element includes a phosphate buffer sufficient to keep the cement composition acidic while curing to generate a foamed cement. - View Dependent Claims (14, 15, 16, 17, 18)
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19. A kit comprising a dry element and a wet element, wherein when the dry element comprises tricalcium phosphate, hydroxyapatite, strontium hydrophosphate and one or more members selected from the group consisting of strontium carbonate and sodium bicarbonate and the wet element comprises a phosphate buffer sufficient to keep the composition acidic when the dry element and the wet element are mixed together resulting in a foamed cement that is suitable for bone remodeling.
- 20. The kit of claim 32, further comprising an antibiotic.
Specification