TREATING HEART FAILURE AND VENTRICULAR ARRHYTHMIAS
First Claim
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1. A method for treating arrhythmia in a subject with ischemic heart disease, comprising enhancing the function of SERCA2a, thereby treating the arrhythmia in the subject.
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Abstract
The present invention provides methods and materials for treating heart disorders, including heart failure and arrhythmia, by enhancing SERCA2a activity. Heart cells in a subject can be treated, for example, by introducing, into the heart of the subject, an adeno-associated virus subtype 6 (AAV6) viral delivery system that includes a functional nucleic acid encoding SERCA2a. For example, the functional nucleic acid encodes a non-viral therapeutic protein, thereby treating the subject.
58 Citations
46 Claims
- 1. A method for treating arrhythmia in a subject with ischemic heart disease, comprising enhancing the function of SERCA2a, thereby treating the arrhythmia in the subject.
- 19. A method for protecting against tissue damage or death caused by reperfusion-induced arrhythmia in a subject with acute myocardial ischemia comprising enhancing the function of SERCA2a, thereby protecting against tissue damage or death.
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32. A method for reducing risk of death or injury due to arrhythmia in a subject with ischemic heart disease, comprising:
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occluding a coronary artery and a coronary vein with a first and second angioplasty balloon, respectively, thereby restricting the flow of blood through the coronary vessels; injecting through the lumen of the first angioplasty balloon into the lumen of the coronary artery a recombinant expression vector encoding SERCA2a, thereby causing the vector to perfuse the myocardium, wherein the vector thereafter expresses the SERCA2a in the myocardium, thereby reducing risk of death or injury due to arrhythmia in a subject with ischemic heart disease. - View Dependent Claims (33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46)
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Specification