Apparatus and method for non-invasive, in-vivo, thoracic radio interrogation

• US 20090240133A1
• Filed: 03/23/2009
• Published: 09/24/2009
• Est. Priority Date: 09/21/2006
• Status: Abandoned Application

• Current Assignee: Caldwell Simpson LLC
• Original Assignee: Non-invasive Medical Technologies
• Inventors: Friedman, Robert, Pal, Andrew
• Application Number:
  US12/383,357
• Publication Number:
  US 20090240133A1
• Time in Patent Office: Days
• US Class Current: 600/407
• CPC Class Codes: A61B 5/0002 Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network A61B5/07 takes precedence; transmission systems for measured values G08C; transmission H04B; transmission of digital information H04L; wireless communication networks H04W
• CPC Class Codes: A61B 5/02028 Determining haemodynamic parameters not otherwise provided for, e.g. cardiac contractility or left ventricular ejection fraction
• CPC Class Codes: A61B 5/02438 with portable devices, e.g. worn by the patient
• CPC Class Codes: A61B 5/029 Measuring or recording blood output from the heart, e.g. minute volume A61B8/065 takes precedence
• CPC Class Codes: A61B 5/0295 using plethysmography, i.e. measuring the variations in the volume of a body part as modified by the circulation of blood therethrough, e.g. impedance plethysmography
• CPC Class Codes: A61B 5/05 Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves impedance plethysmography A61B5/0295; measuring movement of the entire body or parts thereof A61B5/11; detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof A61B5/24
• CPC Class Codes: A61B 5/0507 using microwaves or terahertz waves
• CPC Class Codes: A61B 5/0816 Measuring devices for examining respiratory frequency measuring frequency of electric signals G01R23/00
• CPC Class Codes: A61B 8/04 Measuring blood pressure
• CPC Class Codes: A61B 8/06 Measuring blood flow measuring volume flow in general G01F, e.g. G01F1/66, G01F1/72; measuring speed of fluids in general G01P5/00
• CPC Class Codes: A61B 8/4236 characterised by adhesive patches

Abstract

A radio apparatus and method for non-invasive, thoracic radio interrogation of a subject for the collection of hemodynamic, respiratory and/or other cardiopulmonary related data from the subject includes a antenna positionable proximally to the subject, a radio transmitter transmitting an unmodulated radio interrogation signal of a predetermined fixed frequency at a safe level of about 1 milliwatt or less from the antenna into the subject and a radio receiver capturing through the antenna, reflections of the transmitted radio interrogation signal returned from the subject. A Doppler component of the reflections contains the data that can be extracted from the captured reflections.

Claims

1. A radio apparatus for non-invasive, in-vivo, thoracic radio interrogation of a subject to collect hemodynamic, respiratory and/or other cardiopulmonary related data from the subject comprising:

an antenna sized to be positioned proximally to the subject outside the subject;

a radio transmitter operably connected to the antenna and configured to transmit only an unmodulated radio interrogation signal of a predetermined, fixed frequency through the antenna and into the proximally positioned subject; and

a radio receiver operably connected to the antenna and configured to capture through the antenna reflections of the transmitted radio interrogation signal returned from the subject.

2. The radio apparatus according to claim 1 wherein predetermined fixed frequency of the radio frequency impedance interrogation signal is an ultra high frequency.

3. The radio apparatus according to claim 1, wherein the ultra high frequency is between 900 and 930 MHz.

4. The radio apparatus according to claim 1, wherein the radio frequency interrogation signal broadcast from the antenna essentially lacks noise components below at least about one hundred Hertz.

5. The radio apparatus according to claim 1 wherein the radio transmitter comprises a source of a signal of the fixed predetermined frequency and wherein the radio transmitter comprises an amplifier operably connected between the source and the antenna to amplify the source signal sufficiently to transmit the radio interrogation signal from the antenna at a strength no greater than about one milliwatt.

6. The radio apparatus according to claim 1 further comprising a duplexer operably connected between the radio transmitter and the antenna and between the antenna and the radio receiver for simultaneous operation of the radio transmitter and the radio receiver through the antenna.

7. The radio apparatus according to claim 6 wherein:

the radio receiver includes a quadrature demodulator operably connected with the duplexer; and

the quadrature demodulator outputs at least one signal containing Doppler components extracted from the reflections of the radio interrogation signal.

8. The radio apparatus according to claim 7 wherein the radio receiver further comprises a high pass filter operably connected to the quadrature demodulator and configured to pass Doppler components extracted from the reflections of the radio interrogation signals and having frequencies above about one hertz.

10. The radio apparatus of claim 7 further comprising processing circuitry operably coupled with the quadrature demodulator so as to receive at least the Doppler components extracted from reflections of the radio interrogation signal.

11. The radio apparatus of claim 1 further comprising a palm size housing containing the radio transmitter, the patch antenna and the radio receiver, the transceiver being sufficiently light to be hand carried and placed proximal the subject.

12. The radio apparatus of claim 1 wherein the antenna is a patch antenna.

13. A method for non-invasive, in-vivo, thoracic radio interrogation of a subject to collect hemodynamic, respiratory and/or other cardiopulmonary related data from the subject comprising the steps of:

positioning an antenna proximally to the subject transmitting only an unmodulated radio interrogation signal of a predetermined fixed frequency through the antenna and into the proximately positioned subject; and

capturing through the antenna with an operably connected radio receiver reflections of the transmitted radio interrogation signal returned from the subject.

9. The radio apparatus according to claim 18, wherein the radio receiver further comprises a low pass filter operably connected to the high pass filter and configured to pass Doppler components extracted from the reflections of the radio interrogation signals and having frequencies up to only about one hundred hertz.

14. The method according to claim 13 where the transmitting step comprises transmitting the radio interrogation signal at an ultra high frequency.

15. The method according to claim 13 where the transmitting step comprises transmitting the radio interrogation signal at a frequency between 900 and 930 MHz

16. The method according to claim 13, wherein the transmitting step comprises transmitting the radio interrogation signal essentially without noise components below at least about one hundred Hertz.

17. The method according to claim 13 wherein the transmitting step comprises transmitting the radio interrogation signal from the antenna at a strength no greater than about one milliwatt.

18. The method according to claim 13 further comprising the step of duplexing the transmitting and capturing steps though the patch antenna.

19. The method according to claim 18 further comprising the step of filtering a duplexed radio interrogation signal before broadcasting the radio interrogation signal from the antenna.

20. The method according to claim 18 wherein the duplexing step comprises passing to and from the patch antenna only ultra high frequency signals centered around the predetermined fixed frequency.

21. The method of claim 13 wherein the capturing step comprises extracting Doppler components from the captured reflections of the radio interrogation signals.

22. The method according to claim 13 wherein the extracting step comprises extracting components from the reflected radio interrogation signals having frequencies between about one and 100 hertz.

23. The method according to claim 13, further comprising the initial step of combining the antenna with a radio transmitter to perform the transmitting step and a radio receiver to perform the capturing step all in a palm size housing.

24. The method of claim 23 wherein the positioning step comprises placing the palm size housing on the subject to perform the transmitting and capturing step.

25. The method according to claim 23 wherein the positioning step is performed by placing the housing on clothing of the subject separating the housing from direct contact with the subject.