DRY POWDER INHALATION SYSTEM
First Claim
Patent Images
1. A dry powder inhaler comprising:
- a housing, anda mouthpiece,wherein said housing comprises a mouthpiece engaging section structurally configured to engage with said mouthpiece, andsaid mouthpiece being separable from said housing and having a conduit permitting airflow between an air inlet and an air exit port, and comprising a chamber and an oral placement section;
said mouthpiece further being structurally configured to be moveable within said housing in an engaged position and releasable from said housing at a predetermined position.
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Abstract
Dry powder inhaler systems for pulmonary delivery of pharmaceuticals are disclosed. The dry powder inhalation systems comprise a dry powder inhalation device or inhaler and a cartridge containing a pharmaceutical formulation comprising an active ingredient for delivery to the pulmonary circulation. The present devices provide rugged devices which are reusable, use pre-metered unit dose cartridges which deliver a medicament in a liner manner, and can be disassembled for cleaning. The devices also provide a high resistance inhalation system which enables deagglomeration of dry powder particles, have a consistent airflow, are easy to manufacture and are simple and relatively easy to use.
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Citations
32 Claims
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1. A dry powder inhaler comprising:
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a housing, and a mouthpiece, wherein said housing comprises a mouthpiece engaging section structurally configured to engage with said mouthpiece, and said mouthpiece being separable from said housing and having a conduit permitting airflow between an air inlet and an air exit port, and comprising a chamber and an oral placement section;
said mouthpiece further being structurally configured to be moveable within said housing in an engaged position and releasable from said housing at a predetermined position. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 30, 31, 32)
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13. An inhalation system for pulmonary drug delivery, comprising:
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a dry powder inhaler comprising a housing and a mouthpiece, said housing including an inlet and an outlet port; a cartridge adapted to said dry powder inhaler and containing a dry powder medicament for inhalation; said dry powder inhaler system comprising air conduits configured to have a predetermined airflow distribution around and through said cartridge operably configured to mix the medicament with air forming a powder plume for delivery to a patient'"'"'s pulmonary system; wherein said predetermined airflow distribution through said cartridge ranges from about 10 to 30% of total airflow volume entering said dry powder inhaler during inhalation. - View Dependent Claims (14, 15, 16, 17)
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18. A dry powder inhaler comprising:
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a housing, and a mouthpiece assembly, said housing having a top wall, a bottom wall, a first side wall and a second side wall;
a mouthpiece engaging section, a mouthpiece storage section, and an air intake section having a conduit with a first opening to allow ambient air intake and a second opening in communication with the mouthpiece engaging section which allows air flow therethrough;said mouthpiece assembly being separable from said housing and comprising a chamber structurally configured to house a cartridge and to engage with said mouthpiece engaging section of said housing;
an oral placement section extending from said chamber and having an air inlet which communicates with said chamber and an air outlet in communication with ambient air. - View Dependent Claims (19, 20, 21, 22, 23, 24, 25, 26)
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27. An inhalation system for pulmonary drug delivery, comprising:
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a) a dry powder inhaler comprising a housing, and a mouthpiece assembly, said housing having a top wall, a bottom wall, side walls;
a mouthpiece engaging section, a mouthpiece storage section, and an air intake section having a conduit with a first opening to allow ambient air intake and a second opening in communication with the mouthpiece engaging section which allows air flow therethrough;said mouthpiece assembly being separable from said housing and comprising a chamber structurally configured to house a cartridge and to engage with said mouthpiece engaging section of said housing;
an oral placement section extending from said chamber and having an air inlet which communicates with said chamber and an air outlet in communication with ambient air; andb) a cartridge adapted to said dry powder inhaler and containing a dry powder medicament for inhalation; said dry powder inhaler system in use has a predetermined air flow distribution around and through said cartridge of air flow volume entering said chamber. - View Dependent Claims (28, 29)
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Specification