Electronic Methods for the Detection of Analytes
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Abstract
The present invention is directed to the detection of target analytes using electronic techniques, particularly AC techniques.
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Citations
34 Claims
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1-19. -19. (canceled)
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20. A method of detecting a target analyte comprising:
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a) contacting a sample comprising said target analyte with an electrode comprising a passivation agent monolayer comprising; i) a covalently attached first passivation species; ii) a covalently attached second passivation species comprising a self-associated binding ligand, whereby upon binding of said target analyte with said binding ligand, said binding ligand is released from self-association; iii) a redox active molecule; and b) detecting a change in a redox property of the redox active molecule as a result of the association of the target analyte with the binding ligand. - View Dependent Claims (21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32)
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33. An apparatus comprising:
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a) a test chamber comprising an array of measuring electrodes, wherein a first and second of said measuring electrodes comprise a passivation agent monolayer comprising; i) a covalently attached first passivation species; ii) a covalently attached second passivation species comprising a self-associated binding ligand, wherein the binding ligand on said first electrode and the binding ligand on said second electrode are different; and b) a voltage source electrically connected to said test chamber. - View Dependent Claims (34)
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Specification