STIMULI-RESPONSIVE SYSTEMS FOR CONTROLLED DRUG DELIVERY
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Accused Products
Abstract
A method of delivering a therapeutic agent by providing a cross-linked polymer encapsulating the therapeutic agent to a site in a patient. The degradation rate of the cross-linked polymer is correlated with a local concentration of an indicator, and the therapeutic agent is released as the cross-linked polymer degrades.
14 Citations
109 Claims
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1-85. -85. (canceled)
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86. A material for delivery of a therapeutic agent in response to an indicator, comprising:
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conjugates that include a therapeutic agent covalently linked to a polymer, wherein the polymer includes two or more indicator analogs; polyfunctional cross-linking agents that cross-link conjugates by non-covalently interacting with indicator analogs on different conjugates, wherein; the material is insoluble in the absence of an indicator that competes with the indicator analogs for non-covalent interactions with the cross-linking agents, and conjugates are released from the material in the presence of the indicator at a rate that depends on the concentration of the indicator, wherein; the indicator is glucose; and the indicator analogs comprise glucose and/or mannose residues. - View Dependent Claims (87, 88, 89, 90, 91, 92, 93, 94, 95, 96, 97, 98, 99, 100, 101, 102, 103, 104, 105, 106, 107, 108, 109)
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Specification