Detection of Phage Amplification by SERS Nanoparticles
First Claim
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1. A phage specific antibody presenting particle comprising:
- a coating comprising at least one reporter molecule attached to the surface of a metal nanoparticle core;
a glass coating attached to the surface of said coating; and
a phage specific antibody attached to the surface of said glass coating.
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Abstract
A phage specific antibody presenting particle, devices and methods related to detection of phage amplification are provided.
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Citations
19 Claims
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1. A phage specific antibody presenting particle comprising:
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a coating comprising at least one reporter molecule attached to the surface of a metal nanoparticle core; a glass coating attached to the surface of said coating; and a phage specific antibody attached to the surface of said glass coating. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
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10. A lateral flow device for detection of phage amplification comprising:
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at least one phage specific antibody presenting particle attached to at least one lateral flow strip; and a Raman spectrometer operably associated with the at least one lateral flow strip to identify said particle to detect phage amplification, wherein the at least one lateral flow strip is configured to be detected by a single Raman source. - View Dependent Claims (11, 12)
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13. A lateral flow device for multiplexing analysis comprising:
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at least one lateral flow strip; at least one phage specific antibody presenting particle with a first type of reporter molecule coating and at least one phage specific antibody presenting particle with a second type of reporter molecule coating operably associated with said at least one lateral flow strip; and a Raman spectrometer operably associated with said one or more lateral flow strips to identify said particle to detect phage amplification, wherein the strips are arranged so they can be detected by a single Raman source. - View Dependent Claims (14, 15, 16)
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17. A lateral flow device for detection of phage amplification comprising:
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a phage specific antibody presenting particle; at least one amplified phage conjugated to said particle; and a solid support comprising; a stationary phase; and a phage specific antibody immobilized on said stationary phase, wherein said antibody binds to said at least one of said phage. - View Dependent Claims (18, 19)
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Specification