BIOSENSOR WITH IMPROVED ANALYTE SPECIFICITY
First Claim
1. A chemistry matrix composition useful in determining the concentration of an analyte, the matrix comprising glucose dehydrogenase, nicotinamide adenine dinucleotide, a 5-alkylphenazine quaternary salt, and a nitrosoaniline, wherein said matrix is stable at a pH of from about 6.5 to about 8.5 and is photochemically stable.
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Abstract
A chemistry matrix for use in determining the concentration of an analyte in a biological fluid includes a glucose dehydrogenase, nicotinamide adenine dinucleotide, an alkylphenazine quaternary salt, and/or a nitrosoaniline. The chemistry matrix is used with an electrochemical biosensor to determine the concentration of an analyte after a reaction occurs within the biosensor, at which time an analysis is completed to determine the concentration. A method of determining the concentration of an analyte using the chemistry matrix of glucose dehydrogenase, nicotinamide adenine dinucleotide, an alkylphenazine quaternary salt, and/or a nitrosoaniline is another aspect that is described. The method also further features test times of five seconds or less. Methods utilizing the new chemistry matrix can readily determine an analyte such as blood glucose at concentrations of from about 20-600 mg/dL at a pH of from about 6.5 to about 8.5.
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Citations
25 Claims
- 1. A chemistry matrix composition useful in determining the concentration of an analyte, the matrix comprising glucose dehydrogenase, nicotinamide adenine dinucleotide, a 5-alkylphenazine quaternary salt, and a nitrosoaniline, wherein said matrix is stable at a pH of from about 6.5 to about 8.5 and is photochemically stable.
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13. A chemistry matrix composition for use in analyzing the concentration of an analyte, the composition comprising glucose dehydrogenase;
- nicotinamide adenine dinucleotide;
a nitrosoaniline and a 5-alkylphenazine quaternary salt having the formula;
- View Dependent Claims (14, 15, 16)
- nicotinamide adenine dinucleotide;
- 17. A chemistry matrix composition for use in analyzing the concentration of an analyte, comprising glucose dehydrogenase, nicotinamide adenine dinucleotide, a nitrosoaniline and a photochemically stable 1-carboxyalkyloxy-5-alkylphenazine useful for determining the concentration of an analyte.
- 20. A method for the electrochemical analysis of an analyte in a liquid sample, which comprises reacting the analyte with the matrix including glucose dehydrogenase, nicotinamide adenine dinucleotide, a nitrosoaniline and a photochemically stable 1-carboxyalkyloxy-5-alklyphenazine to provide an electro-active agent, measuring an electrochemical response produced by the electro-active agent, and determining the analyte concentration in the liquid sample based on the electrochemical response measured.
- 23. A method for the electrochemical analysis of an analyte in a liquid sample, which comprises applying the sample to an application area of a biosensor having a test strip including a chemistry matrix, quantifying the analyte by reaction with the chemistry matrix and displaying a result of said quantifying on a display of a monitoring device configured for use with said biosensor, wherein said chemistry matrix includes glucose dehydrogenase, nicotinamide adenine dinucleotide, a nitrosoaniline, and a 5-alkylphenazine quaternary salt having the formula:
Specification