Method and System for Non-Invasive Blood Glucose Detection Utilizing Spectral Data of One or More Components Other Than Glucose

• US 20090247843A1
• Filed: 03/20/2009
• Published: 10/01/2009
• Est. Priority Date: 03/25/2008
• Status: Active Grant

• Current Assignee: St. Louis Medical Devices, Inc.
• Original Assignee: Curators of the University of Missouri (University of Missouri)
• Inventors: Xu, Zhi
• Granted Patent: US 10,542,919 B2
• Time in Patent Office: Days
• US Class Current: 600/316
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/1455 using optical sensors, e.g. spectral photometrical oximeters

Abstract

A method and system for detecting glucose in a biological sample is disclosed. This includes illuminating a biological sample with a light source, collecting transmitted, transflected or reflected light from the sample with a detector, generating spectral data of one or more components in the sample other than glucose in a spectral data analysis device, and analyzing the spectral data of the one or more components, sufficient to provide a glucose measurement from the spectral data of the one or more components other than glucose with the spectral data analysis device.

Claims

1. A method for detecting glucose in a biological sample, comprising:

illuminating a biological sample with a light source;

collecting transmitted, transflected or reflected light from the sample with a detector;

generating spectral data of one or more components in the sample other than glucose in a spectral data analysis device; and

analyzing the spectral data of the one or more components, sufficient to provide a glucose measurement from the spectral data of the one or more components other than glucose with the spectral data analysis device.

2. The method of claim 1, further comprising before or after illuminating, calibrating a light source to a reference sample.

3. The method of claim 1, wherein the light source comprises lasers, light emitting diodes, halogen lamps, incandescent lamps or a combination thereof.

4. The method of claim 1, wherein illuminating comprises exposing the biological sample to a light source in at least one of the near infrared, mid-infrared and visible light regions.

5. The method of claim 1, wherein illuminating comprises exposing the biological sample to a light source in the range of about 400 nm to about 2500 nm.

6. The method of claim 1, wherein collecting comprises collecting transmitted, transflected or reflected light with one or more detectors.

7. The method of claim 1, wherein analyzing spectral data comprises performing a pulsation analysis on the spectral data.

8. The method of claim 1, wherein analyzing spectral data comprises performing a stationary analysis on the spectral data.

9. The method of claim 1, wherein analyzing comprises mathematically comparing the changes in absorbance of the one or more components to changes in glucose concentration.

10. The method of claim 1, wherein analyzing comprises eliminating spectral data of the one or more components for changes in absorbance not related to interactions with glucose.

11. The method of claim 1, wherein the biological sample comprises a portion of at least one of a human finger, toe, ear lobe, tongue and arm.

12. A system for detecting glucose in a biological sample, comprising:

a biological sample comprising a plurality of components, the components comprising glucose and at least one component other than glucose;

a light source configured to illuminate the biological sample;

a detector configured to collect transmitted, transflected or reflected light from the sample; and

a spectral data analysis device configured to (1) generate spectral data of one or more components in the sample other than glucose, and (2) analyze the spectral data, sufficient to provide a glucose measurement from the spectral data of the one or more components other than glucose.

13. The system of claim 12, wherein the light source comprises lasers, light emitting diodes, halogen lamps, incandescent lamps or a combination thereof.

14. The system of claim 12, wherein the light source is configured to emit light in at least one of the near infrared, mid-infrared and visible light regions.

15. The system of claim 12, wherein the light source is configured to emit light having a wavelength in the range of about 400 nm to about 2500 nm.

16. The system of claim 12, wherein the detector is configured to collect transmitted, transflected or reflected light.

17. The system of claim 12, wherein the spectral data analysis device is configured to perform a pulsation analysis on the spectral data.

18. The system of claim 12, wherein the spectral data analysis device is configured to perform a stationary analysis on the spectral data.

19. The system of claim 12, wherein the spectral data analysis device is configured to mathematically compare the changes in absorbance of the one or more components to changes in glucose concentration.

20. The system of claim 12, wherein the spectral data analysis device is configured to eliminate portions of the spectral data that are attributable to changes in absorbance not related to interactions with glucose.

21. The system of claim 12, wherein the biological sample comprises a portion of at least one of a human finger, toe, ear lobe, tongue and arm.