POLYMER MEMBRANES FOR CONTINUOUS ANALYTE SENSORS
First Claim
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1. A device for continuous measurement of an analyte concentration, the device comprising:
- a sensing mechanism configured to generate a signal associated with a concentration of an analyte in a host; and
a sensing membrane located over the sensing mechanism, the sensing membrane comprising a bioprotective domain comprising a polymer comprising a surface-active group incorporated therein.
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Abstract
Devices and methods are described for providing continuous measurement of an analyte concentration. In some embodiments, the device has a sensing mechanism and a sensing membrane that includes at least one surface-active group-containing polymer and that is located over the sensing mechanism. The sensing membrane may have a bioprotective layer configured to substantially block the effect and/or influence of non-constant noise-causing species.
808 Citations
43 Claims
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1. A device for continuous measurement of an analyte concentration, the device comprising:
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a sensing mechanism configured to generate a signal associated with a concentration of an analyte in a host; and a sensing membrane located over the sensing mechanism, the sensing membrane comprising a bioprotective domain comprising a polymer comprising a surface-active group incorporated therein. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23)
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24. A device for continuous measurement of an analyte concentration, the device comprising:
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a sensing mechanism configured to generate a signal associated with a concentration of an analyte in a host; and a sensing membrane located over the sensing mechanism, the sensing membrane comprising a bioprotective domain comprising a surface-active group-containing polymer, wherein the device is configured to substantially block an effect or an influence of non-constant noise-causing species such that less than 20% of a total signal corresponds to a non-constant noise component. - View Dependent Claims (25, 26, 27, 28, 29, 30, 31, 32)
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33. A device for continuous measurement of glucose concentration, the device comprising:
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a sensing mechanism configured to generate a signal associated with a concentration of glucose in a host; and a sensing membrane located over the sensing mechanism, the sensing membrane comprising a bioprotective domain comprising a surface-active end group covalently bonded to a base polymer. - View Dependent Claims (34, 35, 36, 37)
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38. A device for continuous measurement of an analyte concentration, the device comprising:
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a sensing mechanism configured to generate a signal associated with a concentration of an analyte in a host; and a sensing membrane located over the sensing mechanism, the sensing membrane comprising a bioprotective domain comprising a polyurethane comprising silicone end groups, wherein the polyurethane further comprises a soft segment configured to control a flux of glucose therethrough. - View Dependent Claims (39, 40, 41, 42, 43)
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Specification