CEREBRAL PERFUSION AUGMENTATION

• US 20090247884A1
• Filed: 06/03/2009
• Published: 10/01/2009
• Est. Priority Date: 03/01/1999
• Status: Active Grant

• Current Assignee: Zoll Circulation Incorporated (Asahi Kasei Corporation)
• Original Assignee: Coaxis Incorporated (Trimble Inc.)
• Inventors: Barbut, Denise R.
• Granted Patent: US 7,993,324 B2
• Time in Patent Office: Days
• US Class Current: 600/486
• CPC Class Codes: A61B 17/12022 Occluding by internal devices, e.g. balloons or releasable wires plugging an opening in the wall of an organ A61B17/0057; occluders for the cervical canal A61F6/146; vas deferens occluders A61F6/20
• CPC Class Codes: A61B 17/12036 partial occlusion
• CPC Class Codes: A61B 17/12099 characterised by the location of the occluder
• CPC Class Codes: A61B 17/12109 in a blood vessel
• CPC Class Codes: A61B 17/12136 Balloons
• CPC Class Codes: A61B 17/12172 having a pre-set deployed three-dimensional shape methods of manufacturing A61B2017/00526
• CPC Class Codes: A61B 5/0215 by means inserted into the body catheters A61M25/00
• CPC Class Codes: A61B 5/4064 Evaluating the brain A61B5/031, A61B5/369, A61B5/14553 take precedence
• CPC Class Codes: A61B 5/4076 Diagnosing or monitoring particular conditions of the nervous system A61B5/4821, A61B5/4824 take precedence
• CPC Class Codes: A61M 2025/0073 Tip designed for influencing the flow or the flow velocity of the fluid, e.g. inserts for twisted or vortex flow general flow characteristics A61M2206/10
• CPC Class Codes: A61M 2025/1052 for temporarily occluding a vessel for isolating a sector
• CPC Class Codes: A61M 2210/127 Aorta
• CPC Class Codes: A61M 2230/30 Blood pressure A61M2230/04 takes precedence
• CPC Class Codes: A61M 25/00 Catheters; Hollow probes dilators A61M29/00; peritoneal catheters A61M1/285; tracheal tubes A61M16/04; for drainage A61M27/00; for uterus, vagina or rectum A61M31/00 ; for measuring or testing A61B; materials for catheters A61L29/00
• CPC Class Codes: A61M 25/0074 Dynamic characteristics of the catheter tip, e.g. openable, closable, expandable or deformable
• CPC Class Codes: A61M 25/0082 Catheter tip comprising a tool
• CPC Class Codes: A61M 25/0662 Guide tubes

Abstract

Methods are provided for partial aortic occlusion for cerebral perfusion augmentation in patients suffering from global or focal cerebral ischemia. The descending aorta is accessed. A device is then located downstream from the takeoff of the brachiocephalic artery. The device is operated to at least partially obstruct blood flow in the aorta during systole and diastole. A physiologic parameter can be measured. The device can then be adjusted to modify the degree of obstruction based on the measured physiologic parameter.

Claims

1. A method for increasing cerebral blood flow, comprising the steps of:

advancing a catheter into the descending aorta, the catheter having a proximal region, a distal region, and an expandable member mounted on the distal region;

locating the expandable member in the aorta;

expanding and maintaining the expandable member to partially obstruct blood flow in the aorta during systole and diastole; and

measuring a physiologic parameter.

2. The method of claim 1, further comprising the step of adjusting the expansion of the expandable member based on the measured physiologic parameter.

3. The method of claim 1, wherein the physiologic parameter is blood pressure.

4. The method of claim 1, wherein the physiologic parameter is cerebral blood flow.

5. The method of claim 1, wherein the expandable member is a balloon.

6. The method of claim 1, wherein blood flow to the cerebral vasculature increases by at least 20%.

7. The method of claim 1, wherein the expandable member is located in the abdominal aorta.

8. A method for increasing cerebral blood flow, comprising the steps of:

advancing a catheter into the descending aorta, the catheter having a proximal region, a distal region, and an expandable member mounted on the distal region;

locating the expandable member in the aorta;

expanding the expandable member to partially obstruct blood flow in the aorta without full occlusion during systole and diastole; and

measuring a physiologic parameter.

9. The method of claim 8, further comprising the step of adjusting the expansion of the expandable member based on the measured physiologic parameter.

10. The method of claim 8, wherein the physiologic parameter is blood pressure.

11. The method of claim 8, wherein the physiologic parameter is cerebral blood flow.

12. The method of claim 8, wherein the expandable member is a balloon.

13. The method of claim 8, wherein blood flow to the cerebral vasculature increases by at least 20%.

14. The method of claim 8, wherein the expandable member is located in the abdominal aorta.

15. A method for increasing cerebral blood flow, comprising the steps of:

advancing a catheter into the descending aorta, the catheter having a proximal region, a distal region, and a balloon mounted on the distal region;

locating the balloon in the descending aorta;

expanding and maintaining the balloon to partially obstruct blood flow in the descending aorta during systole and diastole; and

measuring a blood pressure.

16. The method of claim 15, wherein blood flow to the cerebral vasculature increases by at least 20%.

17. The method of claim 15, wherein the balloon is located in the abdominal aorta.

18. The method of claim 15, further comprising the step of adjusting the expansion of the balloon based on the measured blood pressure.