USE OF MICRONEEDLES FOR SMALL MOLECULE METABOLITE REPORTER DELIVERY
First Claim
Patent Images
1. A system for delivering at least one small molecule metabolic reporter (SMMR) into the human epidermis, comprising:
- at least one SMMR; and
a microneedle array;
wherein said microneedle array penetrates said epidermis to facilitate delivery of said SMMR.
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Accused Products
Abstract
Systems that can include a microneedle array and a small molecule metabolic reporter are disclosed. The systems can be used to penetrate the epidermis and monitor the change in concentration of one or more metabolite or analyte.
565 Citations
14 Claims
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1. A system for delivering at least one small molecule metabolic reporter (SMMR) into the human epidermis, comprising:
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at least one SMMR; and a microneedle array; wherein said microneedle array penetrates said epidermis to facilitate delivery of said SMMR. - View Dependent Claims (2)
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3. An in vivo method for delivering at least one SMMR into the human epidermis, comprising:
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contacting said SMMR with a microneedle array, and; penetrating said epidermis with said array to a depth of about 10 μ
m, wherein said depth corresponds with the bottom of the dead stratum corneum layer, to about 175 μ
m, wherein said depth corresponds with the top of the dermal layer. - View Dependent Claims (4, 5, 6, 7, 8, 9, 10, 11)
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12. An in vivo method for monitoring the concentration of one or more metabolite or analyte, the method comprising:
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contacting at least one SMMR with a microneedle array; penetrating the human epidermis with said microneedles to a depth of about 10 μ
m, wherein said depth corresponds with the bottom of the dead stratum corneum layer, to about 175 μ
m, wherein said depth corresponds with the top of the dermal layer; andmonitoring a change in the concentration of the one or more metabolite or analyte in a metabolic pathway by detecting changes in the at least one SMMR at one or more time points using an optical reader. - View Dependent Claims (13, 14)
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Specification