Microparticle delivery syringe and needle for placing suspensions and removing vehicle fluid

• US 20090248162A1
• Filed: 03/25/2008
• Published: 10/01/2009
• Est. Priority Date: 03/25/2008
• Status: Abandoned Application

• Current Assignee: Warsaw Orthopedic Incorporated (Medtronic Plc)
• Original Assignee: Warsaw Orthopedic Incorporated (Medtronic Plc)
• Inventors: Peckham, Steven Marquis
• Application Number:
  US12/055,033
• Publication Number:
  US 20090248162A1
• Time in Patent Office: Days
• US Class Current: 623/17.160
• CPC Class Codes: A61F 2/30965 Reinforcing the prosthesis by embedding particles or fibres during moulding or dipping
• CPC Class Codes: A61F 2/4455 for the fusion of spinal bodies, e.g. intervertebral fusion of adjacent spinal bodies, e.g. fusion cages intervertebral discs A61F2/442
• CPC Class Codes: A61F 2/446 having a circular or elliptical cross-section substantially parallel to the axis of the spine, e.g. cylinders or frustocones
• CPC Class Codes: A61F 2/4465 having a circular or kidney shaped cross-section substantially perpendicular to the axis of the spine
• CPC Class Codes: A61F 2/447 substantially parallelepipedal, e.g. having a rectangular or trapezoidal cross-section
• CPC Class Codes: A61F 2/4611 of spinal prostheses
• CPC Class Codes: A61F 2002/30131 horseshoe- or crescent- or C-shaped or U-shaped
• CPC Class Codes: A61F 2002/30235 tubular, e.g. sleeves
• CPC Class Codes: A61F 2002/30772 Apertures or holes, e.g. of circular cross section
• CPC Class Codes: A61F 2002/3082 Grooves
• CPC Class Codes: A61F 2002/30904 serrated profile, i.e. saw-toothed
• CPC Class Codes: A61F 2002/3092 having an open-celled or open-pored structure
• CPC Class Codes: A61F 2230/0013 Horseshoe-shaped, e.g. crescent-shaped, C-shaped, U-shaped
• CPC Class Codes: A61F 2230/0069 cylindrical
• CPC Class Codes: A61F 2310/00353 Bone cement, e.g. polymethylmethacrylate or PMMA
• CPC Class Codes: A61F 2310/00365 Proteins; Polypeptides; Degradation products thereof

Abstract

Described are reinforced, load-bearing medical implants and methods for preparing and using them. In one aspect a load-bearing orthopedic implant includes a reinforcing polymeric structure including a continuous piece having an internal interconnected porous network. A hardened, calcium-containing material is formed as a non-sintered load-bearing body encompassing the reinforcing structure and filling the internal porous network of the structure.

Claims

1. A method for preparing a load-bearing medical implant, comprising:

providing a reinforcing collagen structure, said reinforcing collagen structure including a continuous piece sufficiently rigid to hold shape when positioned within a mold cavity, said reinforcing collagen structure including a plurality of connected collagen struts defining spaces between the struts, and further wherein said collagen struts each have an internal communicating porous network;

inserting the reinforcing collagen structure into a mold cavity; and

filling the mold cavity having the reinforcing collagen structure inserted therein with a flowable, hardenable calcium-containing material, said filling sufficient to drive the flowable, hardenable calcium-containing material into the spaces between the collagen struts and throughout the internal interconnected porous network of the collagen struts; and

causing the flowable, hardenable calcium-containing material to harden to form the load-bearing orthopedic implant.

2. The method of claim 1, wherein said calcium-containing material comprises a calcium phosphate cement.

3. The method of claim 1, wherein said load-bearing orthopedic implant is an interbody spinal fusion implant sized for receipt in an interbody space between adjacent vertebral bodies.

4. The method of claim 1, wherein said reinforcing collagen structure comprises chemically-crosslinked collagen.

5. The method of claim 1, wherein said hardened calcium-containing material is bioresorbable.

6. The method of claim 1, wherein said load-bearing orthopedic implant exhibits a compression strength of at least 10 MPa.

7. The method of claim 1, wherein said collagen struts exhibit a void volume of at least about 50%, and wherein said void volume is essentially completely occupied by the calcium-containing material.

8. A load-bearing medical implant, comprising:

a reinforcing collagen structure, said reinforcing collagen structure including a continuous piece having a plurality of connected porous collagen struts defining spaces between the struts, and further wherein said collagen struts each have an internal interconnected porous network;

a hardened, calcium-containing material formed as a non-sintered load-bearing body encompassing said reinforcing collagen structure, said hardened calcium-containing material filling the spaces between the collagen struts of the reinforcing collagen structure and filling the internal interconnected porous network of said collagen struts.

9. The implant of claim 8, wherein said calcium-containing material comprises calcium phosphate cement.

10. The implant of claim 8, which is an interbody spinal fusion implant sized for receipt in an interbody space between adjacent vertebral bodies.

11. The implant of claim 8, wherein said reinforcing collagen structure comprises chemically-crosslinked collagen.

12. The implant of claim 8, wherein said calcium-containing material is bioresorbable.

13. The implant of claim 8, which exhibits a compressive strength of at least 10 MPa.

14. The implant of claim 8, wherein said porous collagen struts exhibit a void volume of at least about 50%, and wherein said void volume is essentially completely occupied by the calcium-containing material.

15. The implant of claim 14, wherein the calcium-containing material comprises a calcium phosphate cement, and wherein the load-bearing implant exhibits a compressive strength of at least about 10 MPa.

16. The implant of claim 8, wherein said calcium-containing material carries an osteoinductive protein.

17. The implant of claim 16, wherein said osteoinductive protein is a bone morphogenic protein.

23. A method for treating a patient, comprising implanting in the patient an implant according to claim 8.

18. A load-bearing medical implant, comprising:

(i) a reinforcing structure comprising a bioresorbable porous polymeric matrix defining an internal interconnected porous network; and

(ii) a calcium-containing material formed as a hardened, non-sintered load-bearing mass, said mass embedding said reinforcing structure and filling the internal interconnected porous network of said polymeric matrix.

19. The implant of claim 18, wherein said calcium containing material comprises an osteogenic protein.

20. The implant of claim 19, wherein said osteogenic protein is a recombinant human bone morphogenic protein.

21. The implant of claim 18, wherein said polymeric matrix comprises collagen.

22. The implant of claim 18, wherein said porous polymeric matrix exhibits a void volume of at least 50%, with said void volume occupied by said calcium-containing material.

24. A method for treating a patient, comprising implanting in the patient an implant according to claim 18.

25. A method for preparing a load-bearing medical implant, comprising:

(i) providing a reinforcing structure comprising a bioresorbable porous polymeric matrix defining an internal interconnected porous network;

(ii) forming a flowable, hardenable calcium-containing material into a mass embedding said reinforcing structure and filling the internal interconnected porous network of said polymeric matrix; and

(iii) causing said flowable, hardenable calcium-containing material to harden.