Sterile Blood Separating System

• US 20090250413A1
• Filed: 04/04/2008
• Published: 10/08/2009
• Est. Priority Date: 04/04/2008
• Status: Active Grant

• Current Assignee: Biomet Manufacturing, LLC (Zimmer Biomet Holdings, Inc.)
• Original Assignee: Biomet Biologics LLC (Zimmer Biomet Holdings, Inc.)
• Inventors: Hoeppner, Jacy C.
• Granted Patent: US 8,518,272 B2
• Time in Patent Office: Days
• US Class Current: 210/787
• CPC Class Codes: A61M 1/3693 using separation based on different densities of components, e.g. centrifuging
• CPC Class Codes: A61M 1/3696 with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation
• CPC Class Codes: B01D 21/262 by using a centrifuge
• CPC Class Codes: B01D 2221/10 Separation devices for use in medical, pharmaceutical or laboratory applications, e.g. separating amalgam from dental treatment residues
• CPC Class Codes: B01L 2200/026 Fluid interfacing between devices or objects, e.g. connectors, inlet details
• CPC Class Codes: B01L 3/50215 using a float to separate phases
• CPC Class Codes: B04B 2007/025 Lids for laboratory centrifuge rotors
• CPC Class Codes: B04B 5/0442 with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation
• CPC Class Codes: B04B 7/08 Rotary bowls centrifugal casting machines B22D

Abstract

A system for separating components of a composition according to density. The system includes a torque generating device, a separation device, and a housing. The separation device separates the composition into different components according to density. The housing accommodates the separation device. The housing includes a base having an interface that transfers torque from the torque generating device to the separation device, a cover, and a conduit for introducing the composition into the separation device without opening the cover.

Claims

1. A system for separating components of a composition according to density comprising:

a torque generating device;

a separation device for separating the composition into different components according to density; and

a housing that accommodates the separation device including;

a base having an interface that transfers torque from the torque generating device to the separation device;

a cover; and

a conduit for introducing the composition into the separation device without opening the cover.

2. The system of claim 1, wherein the conduit extends through the cover and mates with the separation device.

3. The system of claim 1, wherein the torque generating device includes a motorized rotating platform.

4. The system of claim 1, wherein the separation device includes a buoy separator having a density less than that of red blood cells of whole blood.

5. The system of claim 1, wherein the cover is mounted directly to the separation device and rotates with the separation device.

6. The system of claim 1, wherein the cover is mounted directly to the housing and is stationary when the separation device is rotating.

7. The system of claim 1, wherein the conduit is movable to selectively engage and disengage the separation device without removing the cover.

8. The system of claim 1, wherein the separation device further comprises a counterbalance.

9. The system of claim 1, wherein the composition is whole blood and the components include blood platelets.

10. A method for separating components of a composition according to density comprising:

sealing a sterilized separation device within a container having a base and a cover such that the separation device is in cooperation with an interface at the base of the container;

inserting the composition into the sterilized separation device sealed within the container by injecting the composition through a conduit that extends through the container and mates with the separation device;

mating the container with a torque generating device, the interface in contact with both the torque generating device and the separation device;

spinning the separation device using the torque generating device to separate the composition into different components according to density, the separation device is spun independent of the container and torque is transferred from the torque generating device to the separation device by the interface;

removing the sterile separation device from the container; and

withdrawing at least one of the different components from the separation device as necessary while the separation device is in the sterile environment.

11. The method of claim 10, further comprising inserting the composition into the sterilized separation device through a conduit that extends through the cover.

12. The method of claim 10, wherein the composition is whole blood and spinning the separation device causes a buoy to move within the separation device to separate different blood components, the buoy having a density less than that of red blood cells of the whole blood.

13. The method of claim 10, further comprising spinning the separation device with a motorized rotating base.

14. The method of claim 10, further comprising sealing the separation device within the container by mounting the cover directly to sidewalls of the container.

15. The method of claim 10, further comprising sealing the separation device within the container by mounting the cover directly to the separation device.

16. A container for housing a sterile separation device for separating components of a composition according to density, said container comprising:

a container base having sidewalls extending from said container base to define a receptacle for accommodating said separation device;

an interface at said container base for transferring torque from a torque generating device to said separation device when said separation device is seated within said receptacle;

a cover for covering said receptacle and sealing said sterile separation device within said receptacle to prevent contamination of said sterile separation device; and

a conduit extending through said container to said sterile separation device to permit delivery of blood through said container and into said sterile separation device when said sterile separation device is sealed within said receptacle.

17. The container of claim 16, wherein said conduit extends through said cover.

18. The container of claim 16, wherein said cover is mounted directly to said sidewalls.

19. The container of claim 16, wherein said cover is mounted directly to said separation device.

20. The container of claim 16, wherein said conduit is movable to engage and disengage said separation device when said separation device is seated within said receptacle.