System and Method of Identifying a Potential Lung Nodule

• US 20090252395A1
• Filed: 06/15/2009
• Published: 10/08/2009
• Est. Priority Date: 02/15/2002
• Status: Abandoned Application

• Current Assignee: Board of Regents of the University of Michigan (University of Michigan)
• Original Assignee: Board of Regents of the University of Michigan (University of Michigan)
• Inventors: Hadjiyski, Lubomir M., Petrick, Nicholas, Zhou, Chuan, Sahiner, Berkman, Chan, Heang-Ping
• Application Number:
  US12/484,941
• Publication Number:
  US 20090252395A1
• Time in Patent Office: Days
• US Class Current: 382/131
• CPC Class Codes: A61B 6/03 Computed tomography [CT] echo-tomography A61B8/14
• CPC Class Codes: A61B 6/466 adapted to display 3D data
• CPC Class Codes: A61B 6/583 using calibration phantoms
• CPC Class Codes: G06T 2207/10081 Computed x-ray tomography [CT]
• CPC Class Codes: G06T 2207/30061 Lung
• CPC Class Codes: G06T 7/0012 Biomedical image inspection

Abstract

A computer assisted method of detecting and classifying lung nodules within a set of CT images to identify the regions of the CT images in which to search for potential lung nodules. The lungs are processed to identify a subregion of a lung on a CT image. The computer defines a nodule centroid for a nodule class of pixels and a background centroid for a background class of pixels within the subregion in the CT image; and determines a nodule distance between a pixel and the nodule centroid and a background distance between the pixel and the background centroid. Thereafter, the computer assigns the pixel to the nodule class or to the background class based on the first and second distances; stores the identification in a memory; and analyzes the nodule class to determine the likelihood of each pixel cluster being a true nodule.

Claims

1. A method of identifying a potential lung nodule, the method embodied in a set of machine-readable instructions executed on a processor and stored on a tangible medium, the method comprising:

(a) identifying a subregion of a lung on a computed tomography (CT) image;

(b) defining a nodule centroid for a nodule class of pixels and a background centroid for a background class of pixels within the subregion in the CT image based on two or more versions of the CT image;

(c) determining a nodule distance between a pixel and the nodule centroid and a background distance between the pixel and the background centroid;

(d) assigning the pixel to the nodule class or to the background class based on the first and second distances;

(e) storing in a memory the identification of the pixel if assigned to the nodule class; and

(f) analyzing the nodule class to determine the likelihood of each pixel cluster being a true nodule.

2. The method of claim 1, wherein defining the nodule and the background centroids includes using the CT image and a filtered version of the CT image.

3. The method of claim 2, wherein the filtered version of the CT image is selected from the group of filtered image scans consisting of:

a median filter, a gradient filter, and a maximum intensity projection filter.

4. The method of claim 1, including identifying a subregion of the lung as the region of interest.

5. The method of claim 1, including repeating steps of (c) and (d) for each pixel in the region of interest.

6. The method of claim 5, including redefining the nodule centroid and the background centroid after each pixel in the region of interest has been assigned to the nodule class or to the background class and repeating steps (c) and (d) for each pixel in the region of interest.

7. The method of claim 1, wherein assigning the pixel to the nodule class or to the background class includes determining a similarity measure from the nodule distance and the background distance and comparing the similarity measure to a threshold.

8. The method of claim 1, including defining a nodule as a group of connected pixels assigned to the nodule class to form a solid object and filling in a hole in the solid object using a flood-fill technique.

9. The method of claim 1, including storing an identification of the pixel if assigned to the nodule class in a memory.

10. A lung nodule detection system comprising:

identification means for identifying a subregion of a lung on a computed tomography (CT) image;

means for defining a nodule centroid for a nodule class of pixels and a background centroid for a background class of pixels within the subregion in the CT image based on two or more versions of the CT image;

determining means for determining a nodule distance between a pixel and the nodule centroid and a background distance between the pixel and the background centroid;

means for assigning the pixel to the nodule class or to the background class based on the first and second distances by determining a similarity measure from the nodule distance and the background distance and comparing the similarity measure to a threshold;

means for storing in a memory the identification of the pixel if assigned to the nodule class; and

means for analyzing the nodule class to determine the likelihood of each pixel cluster being a true nodule.

11. The system of claim 10, further comprising means for defining the nodule and the background centroids using the CT image and a filtered version of the CT image.

12. The system of claim 11, further comprising means for selecting the filtered version of the CT image from the group of filtered image scans consisting of:

a median filter, a gradient filter, and a maximum intensity projection filter.

13. The system of claim 10, further comprising means for identifying a subregion of the lung as the region of interest.

14. The system of claim 10, further comprising means for redefining the nodule centroid and the background centroid after each pixel in the region of interest has been assigned to the nodule class or to the background class.

15. The system of claim 10, further comprising means for defining a nodule as a group of connected pixels assigned to the nodule class to form a solid object and means for filling in a hole in the solid object using a flood-fill technique.

16. A method of identifying a potential lung nodule, the method embodied in a set of machine-readable instructions executed on a processor and stored on a tangible medium, the method comprising:

(a) identifying a subregion of a lung on a computed tomography (CT) image;

(b) defining a nodule centroid for a nodule class of pixels and a background centroid for a background class of pixels within the subregion in the CT image based on the CT image and a filtered version of the CT image;

wherein the filtered version of the CT image is selected from the group of filtered image scans consisting of;

a median filter, a gradient filter, and a maximum intensity projection filter.

(c) determining a nodule distance between a pixel and the nodule centroid and a background distance between the pixel and the background centroid;

(d) assigning the pixel to the nodule class or to the background class based on the first and second distances;

(e) storing in a memory the identification of the pixel if assigned to the nodule class;

(f) redefining the nodule centroid and the background centroid after each pixel in the region of interest has been assigned to the nodule class or to the background class and repeating (c) and (d) for each pixel in the region of interest; and

(g) analyzing the nodule class to determine the likelihood of each pixel cluster being a true nodule.

17. The method of claim 16, wherein assigning the pixel to the nodule class or to the background class includes determining a similarity measure from the nodule distance and the background distance and comparing the similarity measure to a threshold.

18. The method of claim 16, including defining a nodule as a group of connected pixels assigned to the nodule class to form a solid object and filling in a hole in the solid object using a flood-fill technique.