VIRUCIDAL DISINFECTANT

• US 20090252775A1
• Filed: 05/28/2009
• Published: 10/08/2009
• Est. Priority Date: 01/28/2005
• Status: Active Grant

• Current Assignee: B. Braun Medical AG (B. Braun Holding GmbH & Co. KG)
• Original Assignee: B. Braun Medical AG (B. Braun Holding GmbH & Co. KG)
• Inventors: Arndt, Andreas, Willi, Olga
• Granted Patent: US 8,697,140 B2
• Time in Patent Office: Days
• US Class Current: 424/402
• CPC Class Codes: A01N 2300/00 Combinations or mixtures of active ingredients covered by classes A01N27/00 - A01N65/48 with other active or formulation relevant ingredients, e.g. specific carrier materials or surfactants, covered by classes A01N25/00 - A01N65/48
• CPC Class Codes: A01N 25/10 Macromolecular compounds
• CPC Class Codes: A01N 31/02 Acyclic compounds
• CPC Class Codes: A01N 59/26 Phosphorus; Compounds thereof
• CPC Class Codes: A61L 2/0088 Liquid substances
• CPC Class Codes: A61L 2/186 Peroxide solutions
• CPC Class Codes: A61L 2202/24 Medical instruments, e.g. endoscopes, catheters, sharps
• CPC Class Codes: A61P 31/12 Antivirals
• CPC Class Codes: E05B 1/0069 Sanitary doorknobs or handles, e.g. comprising a disinfectant
• CPC Class Codes: Y02A 50/30 Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

A virucidal disinfectant having broad-range activity includes an acidic phosphorus compound and/or salt thereof, an alcohol, and one or more polyalkylene glycols. The disinfectant, which may also kill bacteria and/or fungi, may be used for the hygienic disinfection of animate and inanimate surfaces. The invention also provides a disinfection method and a product containing a disinfectant.

Claims

1. A virucidal disinfectant having broad-range activity, comprising:

a) one or more acidic phosphorus compounds selected from the group consisting of phosphoric acid, diphosphoric acid, triphosphoric acid, polyphosphoric acid of general formula H_n+2P_nO_3n+1, where n is an integer of from 1 to 17, cyclotri- and cyclotetrametaphosphoric acids, polymetaphosphoric acid, peroxomonophosphoric acid, peroxodiphosphoric acid, hypophosphoric acid, diphosphoric(III,IV) acid, and salts of these acids;

b) an alcohol component selected from the group consisting of ethanol, propane-1-ol, propane-2-ol, and mixtures of any of these; and

c) one or more polyalkylene glycols;

wherein said one or more acidic phosphorus compounds constitute from 0.2 to 1.5% by weight of the disinfectant.

2. The disinfectant according to claim 1, wherein the alcohol component comprises ethanol and propane-1-ol.

3. The disinfectant according to claim 1, wherein the one or more acidic phosphorus compounds comprises phosphoric acid, one or one or more alkali metal salts of phosphoric acid, or a mixture of any of these.

4. The disinfectant according to claim 1, wherein the one or more acidic phosphorus compounds comprises phosphoric acid, sodium dihydrogenphosphate, potassium dihydrogenphosphate, or a mixture of any of these.

5. The disinfectant according to claim 1, wherein the one or more acidic phosphorus compounds comprises phosphoric acid and one or both of sodium dihydrogenphosphate and potassium dihydrogenphosphate.

6. The disinfectant according to claim 1, wherein the one or more acidic phosphorus compounds or the salts thereof constitute from 0.2 to 1.0% by weight of the disinfectant.

7. The disinfectant according to claim 1, wherein the one or more acidic phosphorus compounds constitute from 0.2 to 0.8% by weight of the disinfectant.

8. The disinfectant according to claim 1, wherein the polyalkylene glycol is etherified in one or more of the terminal hydroxy groups thereof.

9. The disinfectant according to claim 1, wherein the polyalkylene glycol comprises one or more of a polypropylene glycol, an ethylene oxide/propylene oxide block copolymer, and a polyethylene glycol.

10. The disinfectant according to claim 1, wherein the polyalkylene glycol comprises a polyethylene glycol.

11. The disinfectant according to claim 1, wherein the average relative molecular weight of the one or more polyalkylene glycols is in a range from 400 to 10,000.

12. The disinfectant according to claim 1, wherein the average relative molecular weight of the one or more polyalkylene glycols is in a range from 1000 to 8000.

13. The disinfectant according to claim 1, wherein the average relative molecular weight of the one or more polyalkylene glycols is in a range from 2000 to 6000.

14. The disinfectant according to claim 1, wherein the alcoholic component constitutes from 30 to 80% by weight of the disinfectant.

15. The disinfectant according to claim 1, wherein the alcoholic component constitutes from 45 to 80% by weight of the disinfectant.

16. The disinfectant according to claim 1, wherein the alcoholic component constitutes from 60 to 75% by weight of the disinfectant.

17. The disinfectant according to claim 1, wherein the disinfectant has a flash point of at least 21°

C. according to DIN 51755.

18. The disinfectant according to claim 1, further comprising from 0.01 to 5% by weight of one or more skin care components selected from the group consisting of glycerol, propane-1,2-diol, butane-1,3-diol, sorbitol, dexpanthenol, allantoin, bisabolol, tocopheryl acetate, octyidodecanol, dodecanol, tetradecanol, hexadecanol, octadecanol, lanolin alcohol, cetearyl alcohol, cyclomethicone, dimethicone, isopropyl myristate, isopropyl palmitate, cetearylethyl hexanoate, octyl stearate, octyl octanoate, ethylhexanoic acid ethyl ester, jojoba oil, sea buckthorn oil, wool wax, paraffin oil, vaseline, heptamethylnonane/isohexadecane, cholesterol, partial glycerides, triglycerides, and mixtures of any of these.

19. The disinfectant according to claim 18, wherein the one or more skin care components constitute from 0.1 to 2% by weight of the disinfectant.

20. The disinfectant according to claim 1, further comprising from 0.001 to 2% by weight of one or more non-volatile additive components with microbicidal activity selected from the group consisting of benzalkonium chloride, didecyldimethylammonium chloride, mecetronium etilsulfate, octenidine, polyhexamethylene biguanide, chlorohexidine gluconate, chlorohexidine acetate, cetrimide, cetylpyridinium chloride, hexetidine, alkylthiuronium compounds, benzyl alcohol, phenoxyethanol, phenoxypropanols, ethylhexylglycerol, undecylenic acid, 2-biphenylol, triclosan, p-chloro-m-xylenol, thymol, and mixtures of any of these.

21. The disinfectant according to claim 1, further comprising up to 2% by weight of a solubilizer selected from the group consisting of hydrogenated castor oil, fatty alcohol alkoxylates, and mixtures of these.

22. The disinfectant according to claim 1, further comprising up to 2% by weight of one or more denaturing agents, colorants, odor corrigents, or a mixture of any of these.

23. The disinfectant according to claim 1, further comprising an oxygen-releasing compound.

24. The disinfectant according to claim 23, wherein the oxygen-releasing compound comprises hydrogen peroxide.

25. The disinfectant according to claim 23, wherein the oxygen-releasing compound comprises up to 1.0% by weight of the disinfectant.

26. The disinfectant according to claim 1, further comprising one or more refatting agents.

27. The disinfectant according to claim 1, wherein the disinfectant is in the form of a gel.

28. The disinfectant according to claim 1, said disinfectant meeting the recommendation by the Robert Koch Institute for the testing and declaration of effectiveness of disinfectants against viruses and being effective within a minute against adenovirus type 5 (strain Adenoid 75), papovavirus [simian virus 40 (SV40), strain 777], poliovirus (polio vaccination strain type I, strain LSc-2ab), and vaccinia virus (strain Elstree).

43. A product comprising a disinfectant according to claim 1 and means for dispensing the disinfectant.

44. The product according to claim 43, wherein the product comprises a solid support soaked or treated with the disinfectant.

45. The product according to claim 44, wherein the product comprises an impregnated or soaked sheet fabric, an impregnated or soaked nonwoven plastic fabric, impregnated or soaked paper, or a combination of these.

29. A method of killing a pathogen, the method comprising contacting the pathogen with a disinfectant comprising:

a) one or more acidic phosphorus compounds selected from the group consisting of phosphoric acid, diphosphoric acid, triphosphoric acid, polyphosphoric acid of general formula H_n+2P_nO_3n+1, where n is an integer of from 1 to 17, cyclotri- and cyclotetrametaphosphoric acids, polymetaphosphoric acid, peroxomonophosphoric acid, peroxodiphosphoric acid, hypophosphoric acid, diphosphoric(III,IV) acid, and salts of these acids;

b) an alcohol component selected from the group consisting of ethanol, propane-1-ol, propane-2-ol, and mixtures of any of these; and

c) one or more polyalkylene glycols;

wherein said one or more acidic phosphorus compounds constitute from 0.2 to 1.5% by weight of the disinfectant.

30. The method of claim 29, wherein the pathogen comprises an enveloped virus, a non-enveloped virus, or both of these.

31. The method of claim 29, wherein the pathogen comprises at least one virus selected from the group consisting of adenovirus type 5 (strain Adenoid 75), papovavirus [simian virus 40 (SV40), strain 777], poliovirus (polio vaccination strain type I, strain LSc-2ab), vaccinia virus (strain Elstree), bovine viral diarrhea virus, rotaviruses, caliciviruses, coronaviruses, and human and avian influenza A viruses.

32. The method of claim 29, wherein the pathogen comprises a bacterium, a fungus, or both of these.

33. The method according to claim 29, wherein the method is a method of disinfecting a surface comprising contacting the surface with the disinfectant.

34. The method according to claim 33, wherein the surface is an animate surface.

35. The method according to claim 33, wherein the surface comprises human or animal skin.

36. The method according to claim 33, wherein the disinfectant is employed for hygienic hand disinfection, for hand disinfection in surgery, or for exposure to unknown viruses.

37. The method according to claim 33, wherein the disinfectant is employed for hand disinfection in continuous use.

38. The method according to claim 33, wherein the surface is an inanimate surface.

39. The method according to claim 33, wherein the surface is a door handle, a bedstead, a surgical instrument, an article of hospital equipment, or a household article.

40. The method according to claim 29, wherein the method of killing a pathogen is a method of disinfecting a contaminated surface comprising contacting the contaminated surface, for a period of time sufficient to kill a virus, fungus, or bacterium, with the disinfectant.

41. The method according to claim 40, wherein said contacting comprises spraying the disinfectant onto the surface, rubbing the surface with the disinfectant, immersing the surface in the disinfectant, or a combination of these.

42. The method according to claim 40, wherein the surface is human skin.