HYDROGEL POLYMERIC COMPOSITIONS AND METHODS
First Claim
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1. A method of treating an opthalmic disease affecting an eye of a patient by making a hydrogel in a subtenon space or on a sclera or in a conjunctiva of the eye, the method comprising:
- forming an extraocular covalently-crosslinked hydrogel in situ in contact with a sclera or inside a conjunctiva of the eye,wherein the hydrogel comprises a therapeutic agent.
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Abstract
Some aspects of this disclosure relate to a method of treating an opthalmic disease affecting an eye of a patient comprising forming a covalently-crosslinked hydrogel in situ at a peri-ocular, intra-ocular, or intra-vitreal site for controlled release of a therapeutic agent.
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20 Claims
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1. A method of treating an opthalmic disease affecting an eye of a patient by making a hydrogel in a subtenon space or on a sclera or in a conjunctiva of the eye, the method comprising:
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forming an extraocular covalently-crosslinked hydrogel in situ in contact with a sclera or inside a conjunctiva of the eye, wherein the hydrogel comprises a therapeutic agent. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 19, 20)
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12. A synthetic, biocompatible polymeric hydrogel for delivering a therapeutic agent to an eye comprising:
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a first synthetic precursor covalently crosslinked to a second synthetic precursor to form the biocompatible hydrogel, a therapeutic agent in the hydrogel that is released from the hydrogel during a period of time that is at least about two days, wherein the first precursor and the second precursor each comprise a water-degradable group, wherein the hydrogel is low-swelling, as measurable by the hydrogel having a weight increasing no more than about 50% upon exposure to a physiological solution for twenty-four hours relative to a weight of the hydrogel at the time of formation, and wherein the hydrogel is water-degradable, as measurable by the hydrogel being dissolvable in vitro in an excess of water by degradation of water-degradable groups. - View Dependent Claims (13, 14, 15, 16, 17, 18)
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Specification