Integrated Biosensor and Simulation System for Diagnosis and Therapy
First Claim
Patent Images
1. A method for diagnosing an infectious disease or infection comprising the steps of:
- hybridizing biotinylated biological samples acquired from a patient to a site on a microarray comprising biotinylated reporter probes bound to a streptavidin gel;
scanning the microarray with a laser for detecting one or more fluorescence ratios by sensing the fluorescent dye; and
reporting the presence or absence of one or more nucleic acid sequences for specific organisms or genetic mutations associated with disease such that an infection comprising influenza, herpes, chlamydia, pneumonia, or cytomegalic inclusion disease is diagnosable.
0 Assignments
0 Petitions
Accused Products
Abstract
BioMEMS/NEMS appliance biologically monitors an individual, using biosensors to detect cellular components. Data is simulated or analyzed using systems-biology software, which provides diagnostic or therapeutic guidance.
105 Citations
10 Claims
-
1. A method for diagnosing an infectious disease or infection comprising the steps of:
-
hybridizing biotinylated biological samples acquired from a patient to a site on a microarray comprising biotinylated reporter probes bound to a streptavidin gel; scanning the microarray with a laser for detecting one or more fluorescence ratios by sensing the fluorescent dye; and reporting the presence or absence of one or more nucleic acid sequences for specific organisms or genetic mutations associated with disease such that an infection comprising influenza, herpes, chlamydia, pneumonia, or cytomegalic inclusion disease is diagnosable. - View Dependent Claims (2, 3, 5, 6)
-
-
4. An apparatus for diagnosing an infectious disease or infection comprising:
-
microarray comprising biotinylated reporter probes bound to a streptavidin gel for hybridizing biotinylated biological samples acquired from a patient; a laser scanner for scanning the microarray to detect one or more fluorescence ratios by sensing the hybridized biotinylated biological samples; and a user interface for reporting the presence or absence of one or more nucleic acid sequences for specific organisms or genetic mutations associated with disease such that an infection comprising influenza, herpes, chlamydia, pneumonia, or cytomegalic inclusion disease is diagnosable.
-
-
7. An apparatus for diagnosing an infectious disease or infection comprising:
-
a microarray for hybridizing biotinylated biological samples acquired from a patient to a site comprising biotinylated reporter probes bound to a streptavidin gel; an automated platform for scanning the microarray with a laser for detecting fluorescence ratios by sensing the fluorescent dye; and a user interface for reporting the presence or absence of nucleic acid sequences for specific organisms or genetic mutations associated with disease such that an infection comprising influenza, herpes, chlamydia, pneumonia, or cytomegalic inclusion disease is diagnosable. - View Dependent Claims (8)
-
-
9. A method for diagnosing an infectious disease or infection comprising the steps of:
-
hybridizing biotinylated biological samples acquired from a patient to a microarray site comprising biotinylated reporter probes bound to a streptavidin gel; scanning the microarray with a laser for detecting fluorescence ratios by sensing the fluorescent dye; and reporting the presence or absence of nucleic acid sequences for specific organisms or genetic mutations associated with disease such that an infection comprising influenza, herpes, chlamydia, pneumonia, or cytomegalic inclusion disease is diagnosable on a user interface. - View Dependent Claims (10)
-
Specification