Production Of Polyketides And Other Natural Products
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Abstract
The present invention relates to production of polyketides and other natural products and to libraries of compounds and individual novel compounds. Therefore in aspect the present invention provides 17-desmethylrapamycin and analogues thereof, methods for their production, including recombinant strains, and isolation and uses of the compounds of the invention. In a further aspect the present invention provides for the use of 17-desmethylrapamycin and analogues thereof in the induction or maintenance of immunosuppression, the stimulation of neuronal regeneration or the treatment of cancer, B-cell malignancies, fungal infections, transplantation rejection, graft vs. host disease, autoimmune disorders, diseases of inflammation vascular disease and fibrotic diseases, and in the regulation of wound healing.
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Citations
29 Claims
- 1. 17-desmethylrapamycin and analogues thereof.
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16. (canceled)
- 20. A method for generating a recombinant strain that contains a biosynthetic cluster that encodes an engineered rapamycin polyketide synthase where the methylmalonyl-CoA specific AT domain of module 10 is replaced with a malonyl-CoA specific AT domain.
Specification