INTERACTION CONTROL OF CATIONIC BIOCIDES USING LABILE ANIONIC POLYELECTROLYTES

• US 20090253800A1
• Filed: 03/25/2009
• Published: 10/08/2009
• Est. Priority Date: 04/03/2008
• Status: Active Grant

• Current Assignee: Alcon Incorporated
• Original Assignee: Alcon Research Limited (Nestle SA)
• Inventors: DASSANAYAKE, Nissanke L., LUCK, Mary E., DESOUSA, Ryan, KETELSON, Howard Allen
• Granted Patent: US 9,040,510 B2
• Time in Patent Office: Days
• US Class Current: 514/642
• CPC Class Codes: A61L 12/14 Organic compounds not covered by groups A61L12/10 or A61L12/12
• CPC Class Codes: A61L 12/143 Quaternary ammonium compounds
• CPC Class Codes: A61L 12/145 Polymeric quaternary ammonium compounds

Abstract

Methods of inhibiting the uptake of cationic biocides into medical devices such as contact lenses and implants are described. Methods of stabilizing emulsions containing cationic biocides are also described. In particular, the present invention provides for the use of polymers acting as labile anionic polyelectrolytes to reversibly bind cationic biocides. The reversible binding can reduce the deleterious effects of cationic biocides while maintaining biocidal activity. Preferred polymers include galactomannan and polyvinyl alcohol.

Claims

1. A method of inhibiting the uptake of cationic biocides into hydrogel biomaterials, the method comprising adding to an aqueous composition containing a cationic biocide an uptake-inhibiting amount of a labile anionic polyelectrolyte.

2. A method according to claim 1, wherein the labile anionic polyelectrolyte comprises a borate-cis diol polymer complex.

5. A method according to either of claims 1 or 3, wherein the cationic biocide is a polymeric quaternary ammonium compound.

6. A method according to claim 5, wherein the polymeric quaternary ammonium compound is polyquaternium-1.

7. A method according to either of claims 2 or 3, wherein the cis-diol polymer is selected from the group comprising polyvinyl alcohol and galactomannan.

8. A method according to claim 7, wherein the galactomannan is selected from the group consisting of guar gum, locust bean gum, tara gum and chemically modified derivatives thereof.

9. A method according to claim 7, wherein the galactomannan comprises hydroxypropyl guar.

11. A method according to claim 7, wherein the amount of galactomannan in the composition is about 0.01 to 1% weight/volume.

3. A method of inhibiting the uptake of cationic biocides into hydrogel biomaterials, the method comprising adding to a composition containing a cationic biocide and a borate an uptake-inhibiting amount of a cis-diol-containing polymer.

4. A method according to claim 3, wherein the pH of the composition is greater than 7.

10. A method of modulating the bioavailability of cationic biocides, the method comprising adding to a composition containing a cationic biocide a bioavailability-modulating amount of a labile anionic polyelectrolyte.

12. A method of increasing the stability of an emulsion containing a cationic biocide, said method comprising adding to the emulsion an emulsion-stabilizing amount of a labile anionic polyelectrolyte.

13. A method of increasing the stability of an emulsion containing a cationic biocide and a borate, said method comprising adding to the emulsion an emulsion-stabilizing amount of a cis-diol-containing polymer.